Iridoid glucosides from Penstemon diffusus

Diak, Joanna; Kohlmünzer, Stanisłav

doi:10.1135/cccc19852914

Collect. Czech. Chem. Commun.

1985

DOI: 10.1135/cccc19852914

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Iridoid glucosides from Penstemon diffusus

Joanna Diak

Stanisłav Kohlmünzer

Abstract: From the aerial parts of Penstemon diffusus DOUGL. (Scrophulariaceae) have been isolated three iridoid glucosides: penstemide (I), aucubin (V), and loganin (VIII). The identity of the compounds and their derivatives has been confirmed by spectroscopic data.

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Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

Zhang

et al. 2022

Phytotherapy Research

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Iridoid glycosides (IGs) are found in many medicinal and edible plants, such as Gardenia jasminoides, Cistanche tubulosa, Eucommia ulmoides, Rehmanniae Radix, Lonicera japonica, and Cornus officinalis. Loganin, an IG, is one of the main active ingredient of Cornus officinalis Sieb. et Zucc., which approved as a medicinal and edible plant in China. Loganin has been widely concerned due to its extensive pharmacological effects, including anti‐diabetic, antiinflammatory, neuroprotective, and anti‐tumor activities, etc. Studies have shown that these underlying mechanisms include anti‐oxidation, antiinflammation and anti‐apoptosis by regulating a variety of signaling pathways, such as STAT3/NF‐κB, JAK/STAT3, TLR4/NF‐κB, PI3K/Akt, MCP‐1/CCR2, and RAGE/Nox4/p65 NF‐κB signaling pathways. In order to better understand the research status of loganin and promote its application in human health, this paper systematically summarized the phytochemistry, analysis methods, synthesis, pharmacological properties and related mechanisms, and pharmacokinetics based on the research in the past decades.

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Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

Zhang

et al. 2022

Phytotherapy Research

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Iridoid glucosides from Penstemon diffusus

Abstract: From the aerial parts of Penstemon diffusus DOUGL. (Scrophulariaceae) have been isolated three iridoid glucosides: penstemide (I), aucubin (V), and loganin (VIII). The identity of the compounds and their derivatives has been confirmed by spectroscopic data.

Cited by 1 publication

References 0 publications

Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

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