Ipsilateral Synchronous Neoplasms of Kidney Presenting as Acute Pyelonephritis and Bladder Metastasis

A Rare Case of Synchronous Renal Cell Carcinoma of the Bladder Presenting with Gross Hematuria

“…Most of these reports describe a metachronous interval even of years after the initial diagnosis, before bladder metastases become apparent. Although synchronous bladder metastases are less frequently diagnosed, several case studies reported the synchronous spread of metastatic RCC 5-7 . Nevertheless, the pathologic mechanism of urinary bladder involvement remains unknown.…”

“…Interestingly, metastatic disease in these organs often occurs as metachronous metastasis, even years after the initial diagnosis. However, the metastatic spread from RCC to the urinary tract especially to the bladder is a rare event and is described in less than 2% of patients with less than 30 cases published in literature 5-7 . Here, we report the case of a male patient with asymptomatic gross hematuria, diagnosed with a solitary, synchronous bladder metastasis of an advanced RCC of the right kidney with concomitant bone, pulmonary, lymphatic and cerebral metastatic disease.…”

Pyelonephritis in persons after age 50 as a clinical marker of urogenital cancer

“…A number of case reports have described occult urogenital tract cancer presenting as pyelonephritis [3,4], and recent epidemiological studies have reported an increased risk of urinary tract cancer among patients with both upper and lower urinary tract infections (UTIs) [5e8]. However, other studies have found no association or even a decreased risk in subgroups of patients [9].…”

“…A plausible explanation for increased short-term risk of urinary tract cancer in patients with pyelonephritis is that a tumour disrupts the normal urothelial barrier, thereby facilitating bacterial infection [4]. In addition, a tumour mass in the urogenital area could cause compression and obstruction of the urinary tract and induce infection [3].…”

Simultaneous metastases of clear cell renal cell carcinoma to the urinary bladder and left retroperitoneal space: A case report and review of the literature

“…In 20-30% of patients with recently diagnosed RCC, radiological evidence of metastases exists at the time of presentation, and 20-40% of patients undergoing a nephrectomy to treat clinically localized RCC will develop metastases (4). The most common locations prone to metastases are the lungs and bones, followed in frequency by the regional lymph nodes, liver, adrenal gland, brain, gall bladder, pancreas and breasts (5,6). Additionally, several studies have reported a number of rare metastatic sites, including the ureteric stump, the ipsilateral and contralateral ureter, and the prostatic fossa (7)(8)(9).…”