A Rare Case of Synchronous Renal Cell Carcinoma of the Bladder Presenting with Gross Hematuria

Kruck, Stephan; Scharpf, Marcus; Stenzl, Arnulf; Bedke, Jens

doi:10.4081/rt.2013.e19

Cited by 9 publications

(8 citation statements)

References 14 publications

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“…It is a well-established fact that RCC, like melanoma, is a clinical chameleon as it can metastasize to just about any organ in the body [ 1 – 10 ]. With common sites of metastasis being the lungs, bones, liver, and brain, RCC still remains quite unpredictable in its pattern of spread [ 1 , 2 , 4 , 5 , 7 , 10 ]. When secondary testicular cancer of renal origin occurs, it usually presents simultaneously or within a year from primary RCC presentation [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of the Simultaneous, Multifocal, Metastatic Renal Cell Carcinoma to the Ipsilateral Left Testes, Bladder, and Stomach

Kongnyuy

Lawindy

Martinez

et al. 2016

Case Reports in Urology

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We describe the rare case of a 68-year-old gentleman with the history of a hand-assisted laparoscopic left radical nephrectomy for a T2bN0M1 clear cell renal cell carcinoma (RCC). Seven years after surgery and with clean surveillance imaging for metastasis/recurrence the patient presented with three separate tumors suspicious for malignancy. A bladder lesion was found during workup for hematuria, a stomach lesion during diagnostic endoscopy, and a testicular lesion during self-exam. He underwent transurethral resection of bladder tumor, left inguinal orchiectomy, and upper endoscopic ensnarement. All specimens surprisingly showed RCC by histology and immunostaining. These three sites are rare for RCC metastasis and simultaneous presentation is even rarer, further emphasizing the importance of continuous and careful follow-up in this patient population, despite what could appear as complete remission.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of the Simultaneous, Multifocal, Metastatic Renal Cell Carcinoma to the Ipsilateral Left Testes, Bladder, and Stomach

Kongnyuy

Lawindy

Martinez

et al. 2016

Case Reports in Urology

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“…It occurs more commonly in patients with multiple metastases in other organs and confers poor prognosis. 5 Kruck et al, 6 reported a similar case to this one in 2013, where the synchronous diagnosis of bladder metastasis and renal tumor was motivated by a hematuria. In the literature there are few cases reported in the synchronic scenario, as in this case.…”

Section: Discussionmentioning

confidence: 77%

Renal cell carcinoma metastasis in the bladder diagnosed based on transurethral resection after hematuria: a case report

Lima¹

2020

MOJCR

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Introduction: Despite the population's greater access to imaging tests and consequent diagnosis of renal cancer in early stages, we continue to encounter neoplasms in locally advanced and metastatic stages. Case report: We report a patient admitted to the emergency department of the Hospital Geral de Fortaleza with hematuria and urinary retention. After the patient underwent computed tomography and transurethral resection, a diagnosis of renal cell carcinoma metastasis in the bladder was confirmed based on immune histo chemistry results. Discussion: Metastasis of renal cell carcinoma in the bladder is rare, with few cases reported in the literature on synchronic presentation. Final considerations: Although rare, we must consider the possibility of metastasis of renal cell carcinoma in patients who present with hematuria, especially in those previously diagnosed with renal cancer.

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“…Although concurrent bladder and lung cancers are recognized today more frequently than before, with the bladder cancer being mostly the first primary detected, all the reported bladder cancers were transitional cell carcinomas (urothelial carcinoma) [ 18 ]. The possibility of a bladder metastasis from a renal [ 19 ] or ovarian clear cell carcinoma [ 20 ] was excluded in our patient because imaging did not reveal other genitourinary masses. In addition, the RC specimen confirmed the bladder neoplasm location and did not reveal other genital neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Concordant clear cell “mesonephric” carcinoma of the bladder and lung adenocarcinoma with clear cell features – multiple primaries versus metastatic neoplasms: a case report

et al. 2017

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BackgroundClear cell carcinoma of the bladder is a rare variant of urinary bladder adenocarcinoma. We report a case of a patient with clear cell carcinoma of the bladder and a concordant right upper lobe pulmonary adenocarcinoma with clear cell features, and we address the role of immunohistochemistry and cytogenetic analysis in distinguishing the two primary malignancies.Case presentationOur patient was a 59-year-old African American woman who presented with hematuria. Her past medical history included invasive mammary carcinoma and end-stage renal disease treated with hemodialysis. A computed tomographic urogram revealed a 3-cm polypoid bladder mass. A follow-up chest computed tomographic scan revealed a 1-cm right upper lobe nodule. The patient underwent transurethral biopsy and subsequent radical cystectomy, as well as a transthoracic core needle biopsy of the lung nodule. Histologically, the bladder tumor consisted of flat, cuboidal to columnar cells with clear or eosinophilic cytoplasm and a hobnail appearance, organized in tubulocystic and papillary patterns. The neoplastic cells were diffusely positive for α-methylacyl-coenzyme A racemase, cancer antigen 125, and cytokeratin 7; focally positive for cytokeratin 20, P53, and carcinoembryonic antigen; and negative for thyroid transcription factor 1. The lung tumor demonstrated a glandular architecture with mucin production (positive for mucin with mucicarmine and periodic acid-Schiff with diastase stain). The neoplastic cells were diffusely positive for cytokeratin 7, napsin A, and thyroid transcription factor 1, and they were negative for cytokeratin 20 and cancer antigen 125. Genetic testing of the pulmonary neoplasm demonstrated ARID2 genomic alterations.ConclusionsThe presence of clear cell features in both neoplasms raised the possibility of lung metastasis from the primary bladder tumor. However, the glandular architecture of the lung neoplasm along with its distinctive immunohistochemical and genetic profiles confirmed the presence of two separate primaries.

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A Rare Case of Synchronous Renal Cell Carcinoma of the Bladder Presenting with Gross Hematuria

Cited by 9 publications

References 14 publications

A Rare Case of the Simultaneous, Multifocal, Metastatic Renal Cell Carcinoma to the Ipsilateral Left Testes, Bladder, and Stomach

A Rare Case of the Simultaneous, Multifocal, Metastatic Renal Cell Carcinoma to the Ipsilateral Left Testes, Bladder, and Stomach

Renal cell carcinoma metastasis in the bladder diagnosed based on transurethral resection after hematuria: a case report

Concordant clear cell “mesonephric” carcinoma of the bladder and lung adenocarcinoma with clear cell features – multiple primaries versus metastatic neoplasms: a case report

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