Ipsilateral and contralateral serotonergic projections from dorsal and median raphe nuclei to the forebrain in rats: Immunofluorescence quantitative analysis

Kanno, Kouta; Shima, Satoshi; Ishida, Yuki; Yamanouchi, Korehito

doi:10.1016/j.neures.2008.03.001

Cited by 22 publications

(14 citation statements)

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“…Furthermore, disinhibition of RPa neurons using bicuculline results in increases in interscapular BAT (IBAT) sympathetic nerve activity and IBAT temperature (Morrison, 1999; Morrison, 2001; Morrison et al, 1999). Previous tracing studies have shown that both serotonergic and non-serotonergic neurons in the DRVL/VLPAG project to the MPO (Rizvi et al, 1992; Kanno et al, 2008) and to the RPa (Hermann et al, 1997; Bago et al, 2002). Thus, neurons in the DRVL/VLPAG may either influence RPa activity indirectly via projections to hypothalamic thermoregulatory systems that in turn control RPa function, or directly via projections to RPa.…”

Section: Discussionmentioning

confidence: 99%

“…The LPB sends glutamatergic projections to the dorsal raphe nucleus (DR) (Lee et al, 2003). Both the ventrolateral part of the dorsal raphe nucleus/ventrolateral periaqueductal gray (DRVL/VLPAG) (Rizvi et al, 1992; Kano et al, 2008) and the dorsal raphe nucleus, interfascicular part (DRI) (Tillet, 1992) send serotonergic projections to forebrain thermoregulatory areas including the medial preoptic area. GABAergic and glutamatergic projection neurons in the MPO are thought to control dorsomedial hypothalamus/dorsal hypothalamic (DMH/DA) neurons (Nakamura et al, 2005b; Cerri and Morrison, 2006) that in turn project to the raphe pallidus nucleus (RPa) (Yoshida et al, 2009).…”

Section: Figurementioning

confidence: 99%

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Swim stress activates serotonergic and nonserotonergic neurons in specific subdivisions of the rat dorsal raphe nucleus in a temperature-dependent manner

et al. 2011

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Physical (exteroceptive) stimuli and emotional (interoceptive) stimuli are thought to influence stress-related physiologic and behavioral responses through different neural mechanisms. Previous studies have demonstrated that stress-induced activation of brainstem serotonergic systems is influenced by environmental factors such as temperature. In order to further investigate the effects of environmental influences on stress-induced activation of serotonergic systems, we exposed adult male Wistar rats to either home cage control conditions or a 15 min swim in water maintained at 19 °C, 25 °C, or 35 °C and conducted dual immunohistochemical staining for c-Fos, a marker of immediate-early nuclear activation, and tryptophan hydroxylase (TPH), a marker of serotonergic neurons. Changes in core body temperature were documented using biotelemetry. As expected, exposure to cold (19 °C) swim, relative to warm (35 °C) swim, increased c-Fos expression in the external lateral part of the parabrachial nucleus (LPBel), an important part of the spinoparabrachial pathway involved in sensation of cold, cutaneous stimuli, and in serotonergic neurons in the raphe pallidus nucleus (RPa), an important part of the efferent mechanisms controlling thermoregulatory warming responses. In addition, exposure to cold (19 °C) swim, relative to 35 °C swim, increased c-Fos expression in the dorsal raphe nucleus, ventrolateral part/periaqueductal gray (DRVL/VLPAG) and dorsal raphe nucleus, interfascicular part (DRI). Both of these subregions of the dorsal raphe nucleus (DR) have previously been implicated in thermoregulatory responses. Altogether, the data are consistent with the hypothesis that midbrain serotonergic neurons, possibly via activation of afferents to the DR by thermosensitive spinoparabrachial pathways, play a role in integration of physiologic and behavioral responses to interoceptive stress-related cues involved in forced swimming and exteroceptive cues related to cold ambient temperature.

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Swim stress activates serotonergic and nonserotonergic neurons in specific subdivisions of the rat dorsal raphe nucleus in a temperature-dependent manner

et al. 2011

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“…However, the tight midline clustering of the somata of serotonin neurons indicates that they may receive common excitatory and inhibitory inputs (Brown et al, 2002). This and the widely branching pattern of axonal projections of serotonin neurons (Jacobs et al, 1978; Kanno et al, 2008; O'Hearn and Molliver, 1984; Van Der Kooy and Hattori, 1980) suggests that serotonin release may be bilaterally symmetrical. In the present study we measured serotonin release bilaterally during both BSWS and ASWS to determine the actual pattern of release in the fur seal.…”

Section: Introductionmentioning

confidence: 97%

Symmetrical Serotonin Release during Asymmetrical Slow-Wave Sleep: Implications for the Neurochemistry of Sleep–Waking States

et al. 2013

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On land, fur seals predominately display bilaterally synchronized electroencephalogram (EEG) activity during slow-wave sleep (SWS), similar to that observed in all terrestrial mammals. In water, however, fur seals exhibit asymmetric slow-wave sleep (ASWS), resembling the unihemispheric slow-wave sleep of odontocetes (toothed whales). The unique sleeping pattern of fur seals allows us to distinguish neuronal mechanisms mediating EEG changes from those mediating behavioral quiescence. In a prior study we found that cortical acetylcholine release is lateralized during ASWS in the northern fur seal, with greater release in the hemisphere displaying low-voltage (waking) EEG activity, linking acetylcholine release to hemispheric EEG activation (Lapierre et al. 2007). In contrast to acetylcholine, we now report that cortical serotonin release is not lateralized during ASWS. Our data demonstrate that bilaterally symmetric levels of serotonin are compatible with interhemispheric EEG asymmetry in the fur seal. We also find greatly elevated levels during eating and hosing the animals with water, suggesting that serotonin is more closely linked to bilateral variables, such as axial motor and autonomic control, than to the lateralized cortical activation manifested in asymmetrical sleep.

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“…The DR and 5-HT receptor 2A2C systems in female rats have been reported to control ovulation [15]. The DR sends 5-HT projections to the preoptic area (POA) [12]. Few 5-HT-immunopositive fibers are seen within the AVPV, but high-density 5-HT fibers are seen in the cell-sparse zone just lateral to the AVPV [26,27].…”

Section: Discussionmentioning

confidence: 99%

“…The VMN contains large numbers of serotonergic fibers and the distribution pattern is sexually dimorphic [18]. The VMN receives ipsilateral 5-HT inputs from the DR and bilateral 5-HT inputs from the MR and the number of inputs was found to be comparable between these raphe nuclei [12]. A behavioral experiment using a toxin specific to serotonergic neurons has shown that the target of lordosis-inhibiting 5-HT-positive axons is the VMN [14].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory role of the serotonergic system on estrogen receptor α expression in the female rat hypothalamus

Ito

Shimogawa

Kohagura

et al. 2014

Neuroscience Letters

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Ipsilateral and contralateral serotonergic projections from dorsal and median raphe nuclei to the forebrain in rats: Immunofluorescence quantitative analysis

Cited by 22 publications

References 42 publications

Swim stress activates serotonergic and nonserotonergic neurons in specific subdivisions of the rat dorsal raphe nucleus in a temperature-dependent manner

Swim stress activates serotonergic and nonserotonergic neurons in specific subdivisions of the rat dorsal raphe nucleus in a temperature-dependent manner

Symmetrical Serotonin Release during Asymmetrical Slow-Wave Sleep: Implications for the Neurochemistry of Sleep–Waking States

Inhibitory role of the serotonergic system on estrogen receptor α expression in the female rat hypothalamus

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