Inhibitory role of the serotonergic system on estrogen receptor α expression in the female rat hypothalamus

Ito, Hiroyuki; Shimogawa, Y.; Kohagura, Daisuke; Moriizumi, Tetsuji; Yamanouchi, Korehito

doi:10.1016/j.neulet.2014.09.043

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Serotonergic signaling from the DRN strongly innervates other parts of the brain (Phelix et al, 1992;Simerly et al, 1985), and these projections are known to also mediate hypothalamic estrogen receptor (ER) expression (Ito et al, 2014). The VMN, POA, MePD, and DRN are brain regions known for its role in the regulation in female sexual behavior (Arendash and Gorski, 1983;Hoshina et al, 1994;Kato and Sakuma, 2000;Kondo and Sakuma, 2005;Mathews and Edwards, 1977;Pfaff and Sakuma, 1979), and contain high levels of ERα (Laflamme et al, 1998;Yamada et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Female rat sexual behavior is unaffected by perinatal fluoxetine exposure

Hegstad

Huijgens

Houwing

et al. 2020

Preprint

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AbstractSerotonin plays an important role in adult female sexual behavior, however little is known about the influence of serotonin during early development on sexual functioning in adulthood. During early development, serotonin acts as neurotrophic factor, while it functions as a modulatory neurotransmitter in adulthood. The occurrence of serotonin release, could thus have different effects on behavioral outcomes, depending on the developmental period in which serotonin is released. Because serotonin is involved in the development of the HPG axis which is required for puberty establishment, serotonin could also alter expression patterns of for instance the estrogen receptor α (ERα).The aim of our study was to investigate the effects of increased serotonin levels during early development on adult female rat sexual behavior during the full behavioral estrus in a seminatural environment. To do so, rats were perinatally exposed with the selective serotonin reuptake inhibitor (SSRI) fluoxetine (10 mg/kg FLX) and sexual performance was tested during adulthood. All facets of female sexual behavior between the first and last lordosis (behavioral estrus), and within each copulation bout of the behavioral estrus were analyzed. Besides the length and onset of the behavioral estrus and the sexual behaviors patterns, other social and conflict behavior were also investigated. In addition, we studied the effects of perinatal FLX exposure on ERα expression patterns in the medial preoptic nucleus, ventromedial nucleus of the hypothalamus, medial amygdala, bed nucleus of the stria terminalis, and the dorsal raphé nucleus.The results showed that perinatal fluoxetine exposure has no effect on adult female sexual behavior. The behavioral estrus of FLX-females had the same length and pattern as CTR-females. In addition, FLX- and CTR-females showed the same amount of paracopulatory behavior and lordosis, both during the full behavioral estrus and the “most active bout”. Furthermore, no differences were found in the display of social and conflict behaviors, nor in ERα expression patterns in the brain. We conclude that increases in serotonin levels during early development do not have long-term consequences for female sexual behavior in adulthood.

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Section: Discussionmentioning

confidence: 99%

Female rat sexual behavior is unaffected by perinatal fluoxetine exposure

Hegstad

Huijgens

Houwing

et al. 2020

Preprint

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“…However, the addition of trp in the diet must not adversely affect reproduction or growth. Although not entirely understood, it is generally accepted that 5-HT plays a key role in the modulation of reproductive and sexual behavior (Gonzalez et al, 1994;Mcintosh and Barfield, 1984;Snoeren et al, 2014;Zhang et al, 2013), probably acting through the regulation of hypophyseal and steroid hormone levels, and receptors (Ito et al, 2014;Prasad et al, 2015;Senthilkumaran et al, 2001;Somoza et al, 1988;Vitale and Chiocchio, 1993). To our knowledge, there are no previous reports in teleosts on the effects of trp dietary supplements on reproductive physiological parameters, such as reproductive-related steroid plasma levels.…”

Section: Introductionmentioning

confidence: 93%

Serotonergic outcome, stress and sexual steroid hormones, and growth in a South American cichlid fish fed with an l-tryptophan enriched diet

Morandini

Ramallo

Moreira³

et al. 2015

General and Comparative Endocrinology

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“…Among the multiple serotonin receptors that exist in brain, at least 5HT IA , 5HT 2A and 5HT 2C receptors seem to mediate activation of hypothalamic-pituitary-adrenocortical function and studies have demonstrated that direct stimulation of at least these types of receptors mediate the release of oxytocin [29] , prolactin and adrenocorticotropic hormone [7] . Besides the regulation of these molecules fundamental for maternal behaviors, serotonin also can influence other important parameters such as the expression of estrogen receptors [30] and the secretion of vasopressin [29] . The modulation of maternal processes by serotonin is also supported by studies of mice overexpressing the Rai1 (retinoic acid-induced) gene.…”

Section: Indirect Actionsmentioning

confidence: 99%

Neuronal serotonin in the regulation of maternal behavior in rodents

Angoa‐Pérez

Kuhn

2015

Neurotransmitter

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Maternal behavior is probably the most important pro-social behavior in female mammals, ensuring both the development and survival of her offspring. Signals driving maternal behaviors are complex and involve several brain areas, most of which are innervated by serotonin. Serotonin transmission influences maternal processes indirectly through release of maternally-relevant hormones such as prolactin, oxytocin and vasopressin, but it can also have more direct effects on survival and the growth rate of offspring, as well as on maternal care, aggression and pup killing. This article aims to examine the basics of the components of maternal behaviors in rodents and the neural systems underpinning these maternal responses with special emphasis on the role of neural serotonin in the regulation of these behaviors.

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Inhibitory role of the serotonergic system on estrogen receptor α expression in the female rat hypothalamus

Cited by 9 publications

References 33 publications

Female rat sexual behavior is unaffected by perinatal fluoxetine exposure

Female rat sexual behavior is unaffected by perinatal fluoxetine exposure

Serotonergic outcome, stress and sexual steroid hormones, and growth in a South American cichlid fish fed with an l-tryptophan enriched diet

Neuronal serotonin in the regulation of maternal behavior in rodents

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