Iontophoretic permselective property of human nail

Murthy, S. Narasimha; Waddell, Daniel C.; Shivakumar, H.N.; Balaji, Anna; Bowers, Christopher Paul

doi:10.1016/j.jdermsci.2006.12.010

Cited by 59 publications

(52 citation statements)

References 8 publications

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“…Approximately one-third of the patients cannot be completely cured after six or more weeks of oral medication due to treatment failure and relapse (Gupta and Shear, 1999;Gupta et al, 2001;Finch and Warshaw, 2007). Recently, iontophoresis has been demonstrated as a promising method for enhancing drug delivery through the human nail plate (James et al, 1986;Murthy et al, 2007a;Murthy et al, 2007b). Iontophoresis is a noninvasive delivery method that employs an electric field to enhance the transport of a compound across *Corresponding author,Tel: (513) Fax: (513) 558-0978; E-mail address: kevin.li@uc.edu.a membrane (Kasting, 1992).…”

Section: Introductionmentioning

confidence: 99%

Chemical method to enhance transungual transport and iontophoresis efficiency

Hao

Smith

2008

International Journal of Pharmaceutics

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Transungual transport is hindered by the inherent small effective pore size of the nail even when it is fully hydrated. The objectives of this study were to determine the effects of chemical enhancers thioglycolic acid (TGA), glycolic acid (GA), and urea (UR) on transungual transport and iontophoresis efficiency. In vitro passive and iontophoretic transport experiments of model permeants mannitol (MA), UR, and tetraethylammonium (TEA) ion across the fully hydrated, enhancer-treated and untreated human nail plates were performed in phosphate-buffered saline. The transport experiments consisted of several stages, alternating between passive and anodal iontophoretic transport at 0.1 mA. Nail water uptake experiments were conducted to determine the water content of the enhancer-treated nails. The effects of the enhancers on transungual electroosmosis were also evaluated. Nails treated with GA and UR did not show any transport enhancement. Treatment with TGA at 0.5 M enhanced passive and iontophoretic transungual transport of MA, UR, and TEA. Increasing the TGA concentration to 1.8 M did not further increase TEA iontophoresis efficiency. The effect of TGA on the nail plates was irreversible. The present study shows the possibility of using a chemical enhancer to reduce transport hindrance in the nail plate and thus enhance passive and iontophoretic transungual transport.

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Section: Introductionmentioning

confidence: 99%

Chemical method to enhance transungual transport and iontophoresis efficiency

Hao

Smith

2008

International Journal of Pharmaceutics

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“…Iontophoresis is the most effective technique for driving a higher amount of drug into the nail through the dense keratin layer [24][25][26][27][28]. With the aid of iontophoresis, drug depot can be formed into the layers of nail keratin which gradually releases drug with time [29].…”

Section: Iontophoresismentioning

confidence: 99%

Transungual permeation: current insights

Bhuptani

Deshpande

Patravale

2015

Drug Deliv. and Transl. Res.

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Nail disorders are beyond cosmetic concern; besides discomfort in the performance of daily chores, they disturb patients psychologically and affect their quality of life. Fungal nail infection (onychomycosis) is the most prevalent nail-related disorder affecting a major population worldwide. Overcoming the impenetrable nail barrier is the toughest challenge for the development of efficacious topical ungual formulation. Sophisticated techniques such as iontophoresis and photodynamic therapy have been proven to improve transungual permeation. This article provides an updated and concise discussion regarding the conventional approach and upcoming novel approaches focused to alter the nail barrier. A comprehensive description regarding preformulation screening techniques for the identification of potential ungual enhancers is also described in this review while highlighting the current pitfalls for the development of ungual delivery.

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“…In an another study, Murthy et al 51 reported that salicyclic acid delivery across human nail, where the increase in the current density directly increases the number of ions moving across the barrier. Other factors which affects the delivery are the pH and drug concentration 52 .…”

Section: Transungual Iontophoresismentioning

confidence: 99%

Advances in iontophoresis for drug delivery

Dehghan¹,

Mouzam²

2010

Int J Health Res

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an online international journal allowing free unlimited access to abstract and full-text of published articles. The journal is devoted to the promotion of health sciences and related disciplines (including medicine, pharmacy, nursing, biotechnology, cell and molecular biology, and related engineering fields). It seeks particularly (but not exclusively) to encourage multidisciplinary research and collaboration among scientists, the industry and the healthcare professionals. It will also provide an international forum for the communication and evaluation of data, methods and findings in health sciences and related disciplines. The journal welcomes original research papers, reviews and case reports on current topics of special interest and relevance. All manuscripts will be subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication) will be published without delay. The maximum length of manuscripts should normally be 10,000 words (20 single-spaced typewritten pages) for review, 6,000 words for research articles, 3,000 for technical notes, case reports, commentaries and short communications. Submission of Manuscript:The International Journal of Health Research uses a journal management software to allow authors track the changes to their submission. All manuscripts must be in MS Word and in English and should be submitted online at http://www.ijhr.org. Authors who do not want to submit online or cannot submit online should send their manuscript by e-mail attachment (in single file) to the editorial office below. Submission of a manuscript is an indication that the content has not been published or under consideration for publication elsewhere. Authors may submit the names of expert reviewers or those they do not want to review their papers. Enquiries

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Iontophoretic permselective property of human nail

Cited by 59 publications

References 8 publications

Chemical method to enhance transungual transport and iontophoresis efficiency

Chemical method to enhance transungual transport and iontophoresis efficiency

Transungual permeation: current insights

Advances in iontophoresis for drug delivery

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