Ionizing radiation-induced cataract in interventional cardiology staff

Rajabi, Ahmad Bitarafan; Noohi, Feridoun; Hashemi, Hassan; Haghjoo, Majid; Miraftab, Mohammad; Yaghoobi, Nahid; Rastgou, Fereydon; Malek, Hadi; Faghihi, Hoshang; Firouzabadi, Hassan; Asgari, Soheila; Rezvan, Farhad; Khosravi, Hamidreza; Soroush, Sara; Khabazkhoob, Mehdi

doi:10.5812/cardiovascmed.25148

Cited by 32 publications

(5 citation statements)

References 15 publications

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“…Considering the stochastic risk of radiation that might be experienced by patients undergoing interventional procedures, the risk can be estimated by applying the dose conversion coefficient (DCC), i.e. the effective dose normalized to a dosimetric quantity directly measurable [9]. This study provided calculated effective doses that can be related to the values of DAP that are provided by the X-ray equipment.…”

Section: Resultsmentioning

confidence: 99%

“…Recent study suggests possibility of radiationinduced cataract for medical staff in interventional cardiology [9]. The estimation of staff lens doses in three interventional procedures suggest that more than 800 procedures per year and per operator were necessary to reach the lens dose limit [10], and the elevated opacity risks have been shown in interventional cardiologist's personnel who often have substantial doses to the lens of the eye [11].…”

Section: Introduction mentioning

confidence: 99%

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Occupational and Patient Doses in Interventional Cardiology in Indonesia: A Preliminary Result

Hiswara

Sofyan

et al. 2019

Atom Indo.

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Interventional cardiology is a branch of cardiology that manages the catheter based treatment of structural heart illnesses. These minimally invasive procedures involve inserting catheters and other devices through superficial arterial and venous access sites. Due to increased reliability and advancing technology, the number and complexity of interventional cardiology procedures haves increased in recent years. The increasing complexity of the procedures, however, require longer fluoroscopic duration, leading to increased exposure time to ionizing radiation for the patient and also for the medical staff since they need to remain close to the patient throughout the procedure. This study attempts to investigate the occupational and patient doses during the course of several interventional cardiology procedures in Indonesia, i.e. CA, PCI, cathscan, PA, PTCA, TACE, PAC and peripheral vascular. Occupational doses were measured by using individually packed three chips of TLD-100 placed in over-and under-thyroid shield used by medical staff, over-and under-apron in waist position, inside a special 'eye-D' holder, and inside a ring holder, while patient doses were estimated by using individually packed three TLD-100 chips attached in the x-ray tube. All TLDs were calibrated in the Secondary Standard Dosimetry Laboratory (SSDL) Jakarta. The study was performed in three big hospitals in the cities of Jakarta, Yogyakarta and Semarang. The results show that PCI procedure was the most performed one during the course of this study and gave the highest radiation doses to the staff for all type of doses calculated and measured. The maximum effective doses, eye lens doses, extremity doses, thyroid doses and gonad/ovary doses were 0.098 mSv, 0.1967 mSv, 0.7604 mSv, 0.1760 mSv and 0.0990 mSv, respectively. In the case of patient doses, the mean value of DAP for PTCA procedure of 776.76 Gy cm 2 was the highest compared with those for other procedures. The results of measurement for occupational doses were in general similar to those reported by other authors, but not for patient doses that was found to be 4-5 times higher. Due to the involving of various parameters during the course of interventional cardiology procedures, it was difficult to establish a correlation between the doses received by medical staff and by the patients.

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Section: Resultsmentioning

confidence: 99%

Section: Introduction mentioning

confidence: 99%

Occupational and Patient Doses in Interventional Cardiology in Indonesia: A Preliminary Result

Hiswara

Sofyan

et al. 2019

Atom Indo.

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“…Several theories have been proposed for cataract development, such as excess ultraviolet radiation (UV-r) [ 8 , 9 ] or ionizing radiation [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population

et al. 2016

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PurposeTo determine if the presence of certain polymorphisms in the DNA repair gene XPC and the apoptosis inductor gene p53 is associated with pre-senile cataract development.MethodsWe have performed a retrospective study over three groups of patients. The group with pre-senile cataract formed by 72 patients younger than 55 with cataract surgery. The group with senile cataract formed by 101 patients older than 55 with cataract surgery. The group without cataract was formed by 42 subjects older than 55 without lens opacities. We analyzed the presence of SNP rs2228000 from XPC and rs1042522 from p53; and the relationship between risk factors such as smoking, alcohol intake, hypertension or diabetes.ResultsThe comparison of the genotype distribution in XPC, within the different groups, did not show any statistically significant association in any of our analysis (p>0,05). The comparison of the genotype distribution in p53 within the different groups did not show any statistically significant association (p>0,05); except for the comparison between the pre-senile cataract group and the group with senile cataract where the genotype Pro/Pro (C/C) in the recessive inheritance model showed a higher risk for developing pre-senile cataract (p = 0,031; OR = 1.04–15.97). This association decreased when we performed the analysis adjusting by the studied risk factors (p = 0.056).ConclusionsAllelic variants in the gene XPC are not associated with an increased risk for developing pre-senile cataract. The presence of the genotype Pro/Pro in p53 might be associated with a major risk for developing pre-senile cataract.

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“…The relationship between IR exposure and diseases has not been extensively studied. The adverse health effects of IR on the cardiovascular and nervous systems have been demonstrated recently (Bazyka, Loganovsky, Ilyenko, Chumak, & Bomko, 2015;Bitarafan Rajabi et al, 2015). However, data on the effects of IR on the embryonic system are scarce.…”

Section: Discussionmentioning

confidence: 99%

Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation

Wang

Zhou

Zhao

et al. 2018

Journal Cellular Physiology

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Studies have demonstrated that zebrafish are powerful tools for monitoring environmental toxicity, including radiation hazard. Here we investigated the developmental toxicity of ionizing radiation (IR) in an in vivo embryonic zebrafish model. The effects of heavy ion (12C6+), proton, and X‐ray radiation on early zebrafish embryos were determined. A similar dose‐dependent decrease in the hatch and survival rate of zebrafish embryos was observed after exposure to these irradiations. Exposure of zebrafish embryos to 1–4 Gy IR caused significant loss of pigmentation. Quantitative real‐time reverse transcription polymerase chain reaction, western blot analysis, and in situ hybridization (ISH) experiment revealed that atp5α1 was markedly upregulated in irradiated zebrafish embryos. In addition, IR resulted in a rapid decrease in total adenosine triphosphate (ATP) generation. With dual functions of synthesizing or hydrolyzing ATP, ATP synthase regulated H+ transport crossing the mitochondrial inner. Administration of the mitochondrial ATP synthase inhibitor, oligomycin, partially restored pigmentation in irradiated zebrafish embryos, but the ATPase inhibitor, BTB06584, had no effect. Taken together, these results showed that IR exposure downregulated zebrafish pigmentation through regulation of H+ ion transport in mitochondria.

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Ionizing radiation-induced cataract in interventional cardiology staff

Cited by 32 publications

References 15 publications

Occupational and Patient Doses in Interventional Cardiology in Indonesia: A Preliminary Result

Occupational and Patient Doses in Interventional Cardiology in Indonesia: A Preliminary Result

Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population

Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation

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