This 24-month multicenter randomized controlled trial demonstrated superior reduction in MDIOP and medication use among subjects with mild-to-moderate POAG who received a Schlemm canal microstent combined with phacoemulsification compared with phacoemulsification alone.
PurposeTo determine if the presence of certain polymorphisms in the DNA repair gene XPC and the apoptosis inductor gene p53 is associated with pre-senile cataract development.MethodsWe have performed a retrospective study over three groups of patients. The group with pre-senile cataract formed by 72 patients younger than 55 with cataract surgery. The group with senile cataract formed by 101 patients older than 55 with cataract surgery. The group without cataract was formed by 42 subjects older than 55 without lens opacities. We analyzed the presence of SNP rs2228000 from XPC and rs1042522 from p53; and the relationship between risk factors such as smoking, alcohol intake, hypertension or diabetes.ResultsThe comparison of the genotype distribution in XPC, within the different groups, did not show any statistically significant association in any of our analysis (p>0,05). The comparison of the genotype distribution in p53 within the different groups did not show any statistically significant association (p>0,05); except for the comparison between the pre-senile cataract group and the group with senile cataract where the genotype Pro/Pro (C/C) in the recessive inheritance model showed a higher risk for developing pre-senile cataract (p = 0,031; OR = 1.04–15.97). This association decreased when we performed the analysis adjusting by the studied risk factors (p = 0.056).ConclusionsAllelic variants in the gene XPC are not associated with an increased risk for developing pre-senile cataract. The presence of the genotype Pro/Pro in p53 might be associated with a major risk for developing pre-senile cataract.
Purpose: The mechanisms of elevation of intraocular pressure (IOP) in eyes with open‐angle glaucoma are complex and probably include problems related to alterations in the trabecular network, Schlemm channel and distal collecting channels. Traditional surgeries, such as trabeculectomy and the implantation of a shunt microtube, avoid these structures and divert the aqueous humour to the subconjunctival space. Recently, a growing family of minimally invasive glaucoma (MIGS) surgeries has evolved to achieve the reduction of IOP without blistering by restoring flow through the conventional physiological route of exit. One of the devices in this family is the OMNI® surgical system, which was designed to address the three sources of resistance to output flow: trabecular network, Schlemm channel and distal collectors. Thanks to this device it is possible to perform two procedures with a single surgery and overcome three points of flow resistance. The relative novelty of this device makes it important to monitor and analyse long‐term results in normal clinical practice. Methods: We present 6 clinical cases of chronic open‐angle glaucoma that were subjected to surgery with the OMNI® device, associating cataract phacoemulsification in 5 of them. Results: The reduction in IOP that we have observed at 3 and 6 months is around 30%, which is very similar to what has been published in the literature. Conclusions: In our experience, the OMNI® surgical system has provided a clinically relevant decrease in IOP and the number of active ingredients needed, with a good safety profile, although a greater volume of patients and follow‐up time are required to draw more precise conclusions.
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