Iodine, Thiocyanate and the Thyroid

K, ra Amar

doi:10.4172/2167-0501.1000171

Cited by 11 publications

(6 citation statements)

References 26 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These alterations were also accompanied by inhibition of thyroid peroxidase and 5′ monodeiodinase with a fall in serum T3 and T4 levels. These anatomical and physiological changes may lead to biochemical hypothyroidism [36][37]. More robust studies should be done and appropriate strategies should be designed to decrease the effects of goiterogens like cabbage (on how to create awareness about goiterogenic foods in the community).…”

Section: Discussionmentioning

confidence: 99%

Determinants of iodine deficiency among school age children in Guraghe Zone, Southwest Ethiopia

Abebaw¹,

Oumer²

2020

IJPHS

View full text Add to dashboard Cite

Globally, insufficient iodine intake is found to be the most common preventable cause of mental retardation that results in diminished immunity, decreased school performance and infant and young child death. Ethiopia is the first of the top iodine deficient countries in the world. About 12 million children (school age) get inadequate iodine. Community based cross sectional study was conducted on 792 school age children in Guraghe Zone, Ethiopia to assess the determinants of iodine deficiency. Multistage sampling technique was used to select the study subjects. Data were collected by using pretested questionnaire. Clinical examinations were taken following standard procedures. The collected data were entered into Epi-data and exported to SPSS for analysis. Descriptive statistics was calculated and presented accordingly. Bivariate and multivariable Logistic regression with odds ratios along with the 95% confidence interval was computed and interpreted accordingly. A P-value <0.05 was declared as statistically significant association. Total goiter rate was 8.7%. Factors that had significant association with goiter were: School age children who utilized non iodized salt (AOR=3.12, 95% CI=1.73-5.63), those who consumed cabbage >2 times per week (AOR=1.94, 95% CI=1.10-3.52), and children who got elder (AOR=1.22, 95% CI=1.10-1.41). The study area had mild iodine deficiency disorder. Non iodized salt utilization; frequent cabbage consumption and increased age of children were found to be predictors of goiter. Thus, Interventions should focus on universal salt iodization, besides familiarizing goiterogens to the community at large.

show abstract

Section: Discussionmentioning

confidence: 99%

Determinants of iodine deficiency among school age children in Guraghe Zone, Southwest Ethiopia

Abebaw¹,

Oumer²

2020

IJPHS

View full text Add to dashboard Cite

show abstract

“…These morphological changes were also accompanied by inhibition of thyroid peroxidase and 5′ monodeiodinase with simultaneous decrease in serum thyroxine (T4), and triiodothyronine (T3) levels. These anatomical and physiological changes may lead to absolute biochemical hypothyroidism [73–76].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of goiter among children in Ethiopia and associated factors: a systematic review and meta-analysis

et al. 2019

View full text Add to dashboard Cite

Background: The distribution of goiter among children and its risk factors are not well investigated in Ethiopia. Therefore, this systematic review and meta-analysis was designed to determine the pooled prevalence of goiter and its associated factors among children in Ethiopia. Methods: Electronic web-based searches of PubMed, Google Scholar, EMBASE, and the World Health Organization's Hinari portal (which includes the SCOPUS, African Index Medicus, and African Journals Online databases) were conducted to find primary studies. Relevant data were extracted and descriptive summaries of the studies were presented in tables. The I 2 statistic was used to assess heterogeneity across studies. Funnel plot asymmetry and Egger's tests were used to check for publication bias. A random effects model was used to estimate the pooled prevalence of goiter. Odds ratios (OR) with 95% Confidence Intervals (CI) were also used to determine the association of identified variables with goiter. All statistical analyses were conducted using Stata version 14 software. Results: Our search identified 982 studies, of which, 19 articles were eligible for inclusion in the final meta-analysis. The pooled estimate of goiter among children in Ethiopia was 40.50% (95% CI: 33.6-47.40). The regional distribution of goiter ranged from 44.22 (95% CI: 17.44-71) in Southern Nations Nationalities and Peoples' Region, to 32.79% (95% CI: 19.86-45.73) in Benishangul Gumez region. The prevalence of goiter among female children (44.34%) was higher than among male (32.88%) children. Goiter prevalence was also significantly higher among children who consumed vegetables three or more times per week OR = 1.3 (95% CI: 1.02-1.66); those who had family history of goiter, OR = 2.38 (95% CI: 1.9-2.99); and those whose family stored salt near to fires, OR = 1.4 l (95% CI: 1.1-1.79). Conclusion: The prevalence of goiter among children in Ethiopia was high, and endemic according to the WHO criteria. Our findings suggest the need for interventions to improve salt iodization, and for improved health education on appropriate salt storage. In addition, more research may be needed to improve our understanding of foods that increase the risk of goiter among children.

show abstract

“…Thiocyanate, have a molecular size corresponding to that of iodide, inhibits the incorporation of iodide into thyroglobulin by competing with iodide. It inhibits iodide oxidation, i.e., conversion of I − to I 2 by inhibiting TPO activity ( 31 ).…”

Section: Resultsmentioning

confidence: 99%

Does consumption of pearl millet cause goiter? A systematic review of existing evidence

Anitha,

Upadhyay,

Grando

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

Millets (defined here to also include sorghum) have been consumed in Asian and African countries for centuries, and have in recent years become increasingly popular in Western countries, especially because of their proven health and environmental benefits. Nevertheless, some concerns have been raised that their consumption can interfere with thyroid function and cause goiter. This systematic review aimed to investigate the link between millet consumption and goiter. We found nine papers that were relevant to this topic and included them in this review. Among nine papers eight were on pearl millet and one was on fonio millet. The findings of the review indicate that published literature on the association of pearl millet and increased goiter prevalence are not compelling and strong enough to assert that pearl millet consumed as part of a balanced diet can lead to goiter in the general population. To ensure appropriate factual messaging about millets, we need more scientific research to conclusively state whether millet consumption mediates goitrogenic effects.

show abstract

Iodine, Thiocyanate and the Thyroid

Cited by 11 publications

References 26 publications

Determinants of iodine deficiency among school age children in Guraghe Zone, Southwest Ethiopia

Determinants of iodine deficiency among school age children in Guraghe Zone, Southwest Ethiopia

Prevalence of goiter among children in Ethiopia and associated factors: a systematic review and meta-analysis

Does consumption of pearl millet cause goiter? A systematic review of existing evidence

Contact Info

Product

Resources

About