Iodine Metabolism in a Region of Endemic Goiter

Roche, Marcel; Venanzi, F. De; Spinetti-Berti, Mario; Gerardi, A; Mendez-martinez, J.; Forero, J.

doi:10.3181/00379727-91-22364

Cited by 9 publications

(4 citation statements)

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“…ENDEMIC GOITER ÏN UELB REGION 997 time regarding thyroid hormonogenesis in endémie iodine-deficient goiter. However, the results of previous studies (3)(4)(5)(6) suggest that in this condition, altérations of the sécrétion pattern may occur.…”

Section: August 1961mentioning

confidence: 88%

“…It has been shown by Stanbury et al (3) that in the Mendoza endémie goiter area (South America) the mechanism for adaptation of the thyroid gland to iodine deficiency chiefiy consists of an increased extraction rate of blood iodine. In other goitrous areas, high thyroidal I'^' uptakes have been found to be associated with an accelerated release of labeled hormone, a high conversion ratio and a high level of blood PBI"^ The similarity of thèse findings with the pattern observed in hyperthyroidism led Roche et al (6) to postulate a faster iodine turnover in iodine-deficient goiter. The résulta of the présent investigations are not in accordance with this view.…”

Section: Discussionmentioning

confidence: 99%

“…Either of two explanations could account for thèse results : (a) At the time of opération the greater part of the thyroidal I"' was already discharged from the gland ; this did not seem to be the case, as the thyroidal spécifie activity was in the same range as in the first group and the major part of the accumulated I'^' remained in the gland. (6) The labeled hormone secreted in the first few hours after administration of I'^' had a much higher spécifie activity than the iodine remaining in the gland. This implies that radioiodine is not homogeneously distributed amongst the thyroid iodine stores but enters into two or more functionally distinct compartments with différent turnover times.…”

Section: Thyroidal Sécrétionmentioning

confidence: 98%

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Endemic Goiter in the Uele Region. 11.SYNTHESIS and Secretion of Thyroid Hormones*

Ermans

Bastenie

Galperin

et al. 1961

The Journal of Clinical Endocrinology & Metabolism

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A study was made o f the labeled iodinated amino acids and the spécifie activities of organic iodine in the thyroid and blood of 14 goitrous euthyroid patients of the Uele endémie area (Africa). Partial thyroidectomy was per formed three to ten days after administration of I'^'. The total iodine content of the thyroid was in the normal range, but the concentration of iodine per gram was reduced to about 25 per cent. Although the thyroidal uptake of I"' was in creased in ail the patients, the level of plasma PBI"' was low in some cases (0.05 per cent of the dose per liter at twentyfour hours), and much higher in others (0.44 per cent). In the 8 "low PBP^'" patients the isotopic equilibrium between the thyroidal and extrathyroidal organic iodine pools had not been reached seven days after administration of I"', whereas in tho 6 "high PBP^'" patients the spécifie activity of the organic iodine was two to seven times higher in the blood than in the thyroid gland. In the first group, there was a slowing down of the hormonal sécrétion rate. In the second group, the high PBP" levels suggest the existence of an iodine pool with a fast turnover, functionally différent from the rest of the thyroidal iodine stores. Chromato graphic analysis of thyroid tissue after hydrolysis showed an increase of the MIT^'/DIT'" ratio and a decrease in the labeled iodothyronine fraction. This distribution was probably the resuit of a diminution in the rate of transfer of I"' into the more heavily iodinated compounds. From this study it appears that besides an increased thyroidal iodine uptake, severe iodine deficiency in duces several abnormalities in the synthesis and excrétion of the thyroid hormone.R ECENT expérimental work (1,2) has shown that a prolonged iodine deficient diet induces modifications in the iodinated aminoacid con tent of the thyroid gland. S imilar information is not available at the présent

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Section: August 1961mentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Thyroidal Sécrétionmentioning

confidence: 98%

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Endemic Goiter in the Uele Region. 11.SYNTHESIS and Secretion of Thyroid Hormones*

Ermans

Bastenie

Galperin

et al. 1961

The Journal of Clinical Endocrinology & Metabolism

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“…Sin embargo, en éste y otros trabajos 15 , no se consideró que la pérdida de iodo por las heces podía representar un mecanismo importante en la etiología del b. e. Van Middlesworth 17 , por vez primera, comprobó que en ratas alimentadas con dieta pobre en iodo y mantenidas en estado de equilibrio isotópico, las heces…”

Section: Introductionunclassified

Ingesta de iodo y su eliminación urinaria en una zona de bocio endémico

Muñoz

2017

revista-de-medicina

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Se ha estudiado la ingesta y eliminación urinaria de iodo en los pueblos de Labayen, Urroz de Santesteban y Saldias, situados al norte de la provincia de Navarra, donde previamente se había comprobado la existencia de bocio endémico (b. e.). La ingesta de iodo ha sido de 193 ± 50 gammas por persona y día. La eliminación urinaria de iodo en 24 horas en escolares con b. e. (27 niñas y 26 niños), ha sido de 28 ± 10,2 gammas y de 34 ± 20,8 gammas respectivamente. En 58 escolares (28 niñas y 30 niños) de Pamplona sin bocio, la eliminación urinaria de iodo ha sido significativamente mayor (P = 0,001 en niñas y P = 0,05 en niños). Se piensa que el b. e. de esta zona puede estar en relación con la presencia de substancias bociógenas en la alimentación. Tales substancias bociógenas podrían producir una pérdida de iodo por las heces, lo sería una posible explicación para el balance positivo de iodo encontrado.

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Factors Influencing the Thyroid Uptake of Iodine Isotopes From Nuclear Fission-a Review

Middlesworth

1964

Biology of Radioiodine

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Iodine Metabolism in a Region of Endemic Goiter

Cited by 9 publications

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Endemic Goiter in the Uele Region. 11.SYNTHESIS and Secretion of Thyroid Hormones*

Endemic Goiter in the Uele Region. 11.SYNTHESIS and Secretion of Thyroid Hormones*

Ingesta de iodo y su eliminación urinaria en una zona de bocio endémico

Factors Influencing the Thyroid Uptake of Iodine Isotopes From Nuclear Fission-a Review

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