Iodine Conjugated Pt(IV) Nanoparticles for Precise Chemotherapy with Iodine–Pt Guided Computed Tomography Imaging and Biotin-Mediated Tumor-Targeting

Abstract

Theranostics of platinum (Pt)-based chemotherapy are able to self-track the biodistribution and pharmacokinetics while performing therapeutic effects. Pt-based CT imaging is expected to visualize and monitor the tumor throughout the entire tumor inhibition stage. However, a sufficient Pt concentration is necessary for CT imaging, which may bring about severe nephrotoxicity. A Bio-Pt-I compound is designed and synthesized by conjugation of iodine and biotin to the structure of Pt and further self-assembles into nanoparticles. The introduction of iodine not only enhances the CT imaging signal with a much lower dose of Pt but also overcomes the resistance of tumor cells to Pt-containing nanomedicine by inhibiting the expression of Bcl-2. Furthermore, biotin-mediated tumor targeting increases drug accumulation in tumors. This work combines CT imaging based self-track with efficient cisplatin-resistance reversion ability, which may promote the clinical transformation of Pt-containing nanomedicine.

Pt(IV) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy

“…Although with many successes, the generation of most of these polymer microcarriers often requires additional extra initiators. In contrast, the photo-activatable platinum(IV)-azide complexes (Pt(IV) prodrugs) have been previously encapsulated in nano/microcarriers for tumor therapy due to its transformation to highly cytotoxic Pt(II) species [ [37] , [38] , [39] , [40] , [41] ]. During this photo-activation process, the N 3 • could also be generated from Pt(IV).…”

Nanomaterial-based CT contrast agents and their applications in image-guided therapy

“…However, high concentrations of Pt must be maintained to obtain satisfactory CT imaging results, raising the possibility of serious side effects 139 . Recently, Huang et al synthesized reductant-sensitive bio-Pt-I NPs consisting of iodine-conjugated Pt (IV) compounds and biotin as a theranostic nanomedicine for CT image-guided treatment ( Figure 8 I ) 140 . The bio-Pt-I NPs with high Pt (25.36%) and I (32.99%) contents could be used for CT imaging and real-time dynamic distribution monitoring of nanomedicines.…”

“…(A-D) Adapted with permission from 136 , Copyright 2017 Dove Press Ltd. (E-H) Adapted with permission from 137 , Copyright 2020 Wiley-VCH. (I-M) Adapted with permission from 140 , Copyright 2022 American Chemical Society.…”

Copper iodide microhexagons: a potential therapeutic agent for surface microbial infection and melanoma

“…22,23 Recently, iodine nanoparticles were found to be effective in enhancing proapoptotic genes, and these iodine-based materials are also applicable in tumour tissue diagnosis using the computed tomography technique. 24 So, here, we hypothesise that forming composite particles consisting of copper and iodine will provide a synergistic effect against microbial and cancer cell growth, as iodine will enhance the antibacterial effect of copper. At the same time, copper will enhance the anticancer effect of iodine.…”