Nanomaterial-based CT contrast agents and their applications in image-guided therapy

Jiang, Zeyu; Zhang, Meihua; Li, Peifeng; Wang, Yin; Fu, Qinrui

doi:10.7150/thno.79625

Cited by 39 publications

(15 citation statements)

References 193 publications

(277 reference statements)

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“…Barium suspensions and iodinated small molecules are approved as clinical contrast agents for CT . Nanoparticles have become increasingly popular as CT contrast agents over the past seven years. , In contrast to small-molecule CT contrast agents, nanoparticles can be used for tracking cells and targeted imaging applications. , They have several advantages over small-molecule contrast agents, including long blood-pool residence times. Due to their inertness, nontoxicity, easy synthesis, and strong CT contrast, gold nanoparticles have been proposed as CT contrast agents .…”

Section: Resultsmentioning

confidence: 99%

Biocompatible Cerium Carbonate-Based Nanozymes for Oxidase Activity, Sensing, Computed Tomography Contrast, and Delivery of Small Molecules

Thangudu

Lee

2023

ACS Appl. Nano Mater.

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Metal carbonate-based nanomaterials have received significant attention in environmental to biomedical applications due to their practical availability, low cost, safety, biocompatibility, and scalability. However, so far, metal carbonate nanostructures are only limited to calcium (Ca), magnesium (Mg), barium (Ba), strontium (Sr), and iron (Fe) carbonates. Moreover, enzyme mimetic activities of direct metal carbonate nanoparticles (NPs) are not yet reported. Given the advantages of metal carbonates, it is highly desired to develop novel metal carbonate nanostructures to address environmental and biological needs. Thus, in the present work, we have developed biocompatible cerium oxycarbonate nanoparticles (Ce2(CO3)2O·H2O NPs) and systematically studied the enzymatic, computed tomography (CT) contrast and nanocarrier properties. Results reveal that Ce2(CO3)2O·H2O NPs exhibit enzyme oxidase-like activities by oxidating the colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to produce oxidized TMB (ox-TMB) in the absence of hydrogen peroxide (H2O2), and it obeys the Michaelis–Menten enzymatic pathway. In addition, Ce2(CO3)2O·H2O NPs possess good CT contrast properties in a concentration-dependent manner. Moreover, in vitro cellular uptake imaging studies demonstrated the excellent nanocarrier properties of Ce2(CO3)2O·H2O NPs. Finally, biocompatible studies reveal that the present Ce2(CO3)2O·H2O NPs are biocompatible and safer for practical applications. Overall, we believed that the present multifunctional properties of Ce2(CO3)2O·H2O NPs could be a potential candidate in future environmental and biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Biocompatible Cerium Carbonate-Based Nanozymes for Oxidase Activity, Sensing, Computed Tomography Contrast, and Delivery of Small Molecules

Thangudu

Lee

2023

ACS Appl. Nano Mater.

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“…Cancer is already the second most lethal disease after cardiovascular disease, and this grave situation has led to the search for effective control and intervention techniques 50–52 . Cuproptosis is a new form of PCD proposed in 2022 in which copper ions play an important role 29 .…”

Section: Discussionmentioning

confidence: 99%

Cell death mediated by nanotechnology via the cuproptosis pathway: A novel horizon for cancer therapy

Wei

2023

VIEW

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Cuproptosis, the current form of regulated cell death characterized by copper overload, oligomerization of lipoacylated proteins, and loss of Fe-S cluster proteins, has been proposed to function closely with human diseases, including cancer. Since its first identification in 2022, many strategies have been developed to induce cuproptosis for cancer therapy, such as small-molecule drugs and nanomaterials. Although many reviews related to cuproptosis have been reported, they remain at a basic mechanism level, and a summary covering recent progress in the field of nanotechnologies in cuproptosis-based cancer therapy has not yet been presented. Therefore, it is time to fill the gap and shed light on future directions for the application of this promising tool to fight against cancer. In this minireview, we first expounded the mechanism of action of cuproptosis and emphasized the feasibility of triggering cuproptosis for cancer therapy. The recent progress of cancer treatments based on nanoparticle-induced cuproptosis was then described. Finally, the challenges and future development directions of the emerging field of cuproptosis are also discussed.

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“…[ 52,63,64 ] The merits and demerits of different antibacterial methods are briefly summarized in Table 2 . [ 23b,70 ] To date, multimodal antibacterial therapies employing combinations of antibiotic treatment, photodynamic therapy, gas therapy, etc., have been performed. In addition, multimodal imaging capabilities have been integrated into a multimodal antibacterial platform to visualize the site of infection or the course of treatment.…”

Section: Current Clinical Strategiesmentioning

confidence: 99%

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Yang,

Song,

Dong

et al. 2023

Small

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Antibacterial theranostic nanoplatforms, which integrate diagnostic and therapeutic properties, exhibit gigantic application prospects in precision medicine. However, traditional theranostic nanoplatforms usually present an always‐on signal output, which leads to poor specificity or selectivity in the treatment of bacterial infections. To address this challenge, stimuli‐actuated turn‐on nanoplatforms are developed for simultaneous activation of diagnostic signals (e.g., fluorescent, photoacoustic, magnetic signals) and initiation of antibacterial treatment. Specifically, by combining the infection microenvironment‐responsive activation of visual signals and antibacterial activity, these theranostic nanoplatforms exert both higher accurate diagnosis rates and more effective treatment effects. In this review, the imaging and treatment strategies that are commonly used in the clinic are first briefly introduced. Next, the recent progress of stimuli‐actuated turn‐on theranostic nanoplatforms for treating bacterial infectious diseases is summarized in detail. Finally, current bottlenecks and future opportunities of antibacterial theranostic nanoplatforms are also outlined and discussed.

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Nanomaterial-based CT contrast agents and their applications in image-guided therapy

Cited by 39 publications

References 193 publications

Biocompatible Cerium Carbonate-Based Nanozymes for Oxidase Activity, Sensing, Computed Tomography Contrast, and Delivery of Small Molecules

Biocompatible Cerium Carbonate-Based Nanozymes for Oxidase Activity, Sensing, Computed Tomography Contrast, and Delivery of Small Molecules

Cell death mediated by nanotechnology via the cuproptosis pathway: A novel horizon for cancer therapy

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

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