Pt(IV) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy

Zhang, Qingfei; Wang, Xiaocheng; Kuang, Gaizhen; Zhao, Yuanjin

doi:10.1016/j.bioactmat.2022.12.020

Cited by 24 publications

(21 citation statements)

References 49 publications

(48 reference statements)

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“…The absorption of DPBF mixing with Cy and Cy‐HMPBs at different concentrations was confirmed after irradiated with 808 nm laser (0.7 W/cm 2 ). Furthermore, the different irradiation time (0, 1, 2, 3, 4, 5, and 6 min) of the samples was also detected in this study with similar methods 38 …”

Section: Methodssupporting

confidence: 62%

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Cypate‐loaded hollow mesoporous Prussian blue nanoparticle/hydrogel system for efficient photodynamic therapy/photothermal therapy dual‐modal antibacterial therapy

Xing,

Dong,

Zhang

et al. 2023

J Biomedical Materials Res

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Infectious diseases caused by pathogenic microorganisms are a significant burden on public health and the economic stability of societies all over the world. The appearance of drug‐resistant bacteria has severely blocked the effectiveness of conventional antibiotics. Therefore, developing novel antibiotic‐free strategies to combat bacteria holds huge potential for maximizing validity and minimizing the risk of enhancing bacterial resistance. Herein, a cypate‐loaded hollow mesoporous Prussian blue nanoparticles (Cy‐HMPBs) was built to achieve the PDT/PTT synergistic antimicrobial therapy. The carbomer hydrogel (CH) was combined with the Cy‐HMPBs to form a nanoparticle/hydrogel therapeutic system (Cy‐HMPBs/CH) to reach the goal of local delivery of antimicrobial cargo. The low concentration of Cy‐HMPBs/CH receives over 99% of antimicrobial ability against Escherichia coli and Staphylococcus aureus upon near‐infrared (NIR) irradiation. More importantly, Cy‐HMPBs/CH has favorable biocompatibility and can play therapeutic effects only after laser irradiation, indicating the on‐demand therapy at the targeted region to avert side effects on healthy tissue. This study provides ideas for the design of an antibiotic‐free antimicrobial strategy against infectious diseases.

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Section: Methodssupporting

confidence: 62%

“…Furthermore, the different irradiation time (0, 1, 2, 3, 4, 5, and 6 min) of the samples was also detected in this study with similar methods. 38…”

Section: Photothermal Effect and Singlet Oxygen Generation Studiesmentioning

confidence: 99%

Cypate‐loaded hollow mesoporous Prussian blue nanoparticle/hydrogel system for efficient photodynamic therapy/photothermal therapy dual‐modal antibacterial therapy

Xing,

Dong,

Zhang

et al. 2023

J Biomedical Materials Res

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“…In the past decades, many light-activated molecules such as azobenzene derivatives, spiropyran derivatives, and o-nitrobenzyl moieties have been employed in the light-responsive DDSs [117][118][119]. Some photo-activatable prodrugs like platinum(IV)-azide complexes have also attracted great attention [120][121][122][123][124]. As relevant studies conducted, the light-responsive GDNCs based on lightactivated chemical bonds, molecules, or prodrugs could be applied for improving the therapeutic effect of gene therapy alone or combined with other treatment modalities.…”

Section: Lightmentioning

confidence: 99%

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Zhang

Kuang

et al. 2023

Nano-Micro Lett.

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Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity and few adverse effects. Currently, the development of functional vectors with safety and effectiveness is the intense focus for improving the delivery of nucleic acid drugs for gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential in improving the overall efficiencies of gene therapy and reducing adverse effects via effective protection, prolonged blood circulation, specific tumor accumulation, and controlled release profile of nucleic acid drugs. Besides, synergistic therapy could be achieved when combined with other therapeutic regimens. This review summarizes recent advances in various stimuli-responsive nanocarriers for gene delivery. Particularly, the nanocarriers responding to endogenous stimuli including pH, reactive oxygen species, glutathione, and enzyme, etc., and exogenous stimuli including light, thermo, ultrasound, magnetic field, etc., are introduced. Finally, the future challenges and prospects of stimuli-responsive gene delivery nanocarriers toward potential clinical translation are well discussed. The major objective of this review is to present the biomedical potential of stimuli-responsive gene delivery nanocarriers for cancer therapy and provide guidance for developing novel nanoplatforms that are clinically applicable.

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“…11,[19][20][21] Among these, photocurable hydrogels (such as GELMA, ALGMA, and CS-AEMA) not only possess highly hydrated three-dimensional structures and extracellular matrix-like properties similar to traditional hydrogels but can also be polymerized and shaped under mild light conditions. [22][23][24][25] This process is controllable and avoids the issue of introducing toxicity associated with traditional chemical crosslinkers. The cured hydrogels exhibit controllable physicochemical properties, excellent biocompatibility, and degradation performance, providing favorable cell and tissue ingrowth conditions.…”

Section: Introductionmentioning

confidence: 99%

Photo-crosslinked integrated triphasic scaffolds with gradient composition and strength for osteochondral regeneration

Wang,

Li,

Song

et al. 2024

J. Mater. Chem. B

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Pt(IV) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy

Cited by 24 publications

References 49 publications

Cypate‐loaded hollow mesoporous Prussian blue nanoparticle/hydrogel system for efficient photodynamic therapy/photothermal therapy dual‐modal antibacterial therapy

Cypate‐loaded hollow mesoporous Prussian blue nanoparticle/hydrogel system for efficient photodynamic therapy/photothermal therapy dual‐modal antibacterial therapy

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Photo-crosslinked integrated triphasic scaffolds with gradient composition and strength for osteochondral regeneration

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