Involvement of oxidative stress in increased peripheral nerve firing during spontaneous dysesthesia in a mouse model of ischemia-reperfusion

Kagaya, Kenta; Sasaki, Atsushi; Kino, Yurika; Taniguchi, Hiroyuki; Kuraishi, Yasushi; Andoh, Tsugunobu

doi:10.1016/j.neulet.2016.08.034

Cited by 3 publications

(1 citation statement)

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“…It leads to increased extracellular levels of glutamate causing, mitochondrial dysfunction, and oxidative stress. 7 . Literature suggests that agmatine is neuroprotective effect against transient focal or global cerebral ischemia and also increases astrocytes viability, rescuing these cells from death induced by in vitro oxygen-glucose deprivation model.…”

Section: Hypoxia /Ischemia (Stroke)mentioning

confidence: 99%

Agmatine: A potential Neurotherapeutic Agent

Binjhade

Supare

Ghaywat

et al. 2021

J. Drug Delivery Ther.

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Agmatine, a natural polyamine disregarded almost for over 100 years, was discovered in year 1910. Almost after a decade, several researches on Agmatine indicated its modulatory action at multiple molecular targets such as, nitric oxide synthesis, neurotransmitter systems, and polyamine metabolism unbolt the new avenues for extensive therapeutic applications which includes neurotrauma and neurodegenerative diseases, antidepressant, cognitive disorders. Agmatine exerts its varied biological characteristics and therapeutic potential in diverse arena. Agmatine has been extensively researched for its neuroprotective effect in various types of neurological diseases, including stroke and trauma brain injury along with Parkinson's disease, Alzheimer's disease, Hypoxia /Ischemia. In the present review we have summarized the therapeutic potential of agmatine as protective and regenerative properties in the CNS. Keywords: Agmatine, Neuroprotective, Alzheimer's disease, Parkinson's disease, CNS disorders.

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Section: Hypoxia /Ischemia (Stroke)mentioning

confidence: 99%