Agmatine: A potential Neurotherapeutic Agent

Abstract

Agmatine, a natural polyamine disregarded almost for over 100 years, was discovered in year 1910. Almost after a decade, several researches on Agmatine indicated its modulatory action at multiple molecular targets such as, nitric oxide synthesis, neurotransmitter systems, and polyamine metabolism unbolt the new avenues for extensive therapeutic applications which includes neurotrauma and neurodegenerative diseases, antidepressant, cognitive disorders. Agmatine exerts its varied biological characteristics and therapeutic potential in diverse arena. Agmatine has been extensively researched for its neuroprotective effect in various types of neurological diseases, including stroke and trauma brain injury along with Parkinson's disease, Alzheimer's disease, Hypoxia /Ischemia. In the present review we have summarized the therapeutic potential of agmatine as protective and regenerative properties in the CNS.
 Keywords: Agmatine, Neuroprotective, Alzheimer's disease, Parkinson's disease, CNS disorders.

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

“…Consumption of oxygen and cellular signaling produce ROS such as hydroxyl radical, superoxide anion radical, peroxide, and hydrogen peroxide. The intrinsic antioxidant system regulates ROS balance in normal conditions [ 52 ]. However, there is a discrepancy between ROS generation and clearance in pathological situations, leading to high ROS levels [ 53 ].…”