Neuroprotection by agmatine: Possible involvement of the gut microbiome?

Saha, Priyanka; Panda, Subhrajita; Holkar, Aayusha; Vashishth, Rahul; Rana, Sandeep Singh; Arumugam, Mohanapriya; Ashraf, Ghulam Md; Haque, Shafiul; Ahmad, Faraz

doi:10.1016/j.arr.2023.102056

Cited by 6 publications

(2 citation statements)

References 328 publications

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“…Exogenous Guanidoacetic acid can stimulate hormonal release and neural regulation, alter the metabolic utilization of amino acids (e.g., arginine), and act as an oxidant-antioxidant tuner [ 44 ]. Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous multimodal neuromodulant properties [ 45 ]. L-arginine supplementation can enhance anti-infectious, anti-oxidative responses, and immunity; ameliorate metabolic syndromes (including hypertension, obesity, and dyslipidemia); and treat individuals with preeclampsia, muscular dystrophy, and sickle cell disease [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Landscapes of gut bacterial and fecal metabolic signatures and their relationship in severe preeclampsia

Liu,

Zeng,

et al. 2024

J Transl Med

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Background Preeclampsia is a pregnancy-specific disease leading to maternal and perinatal morbidity. Hypertension and inflammation are the main characteristics of preeclampsia. Many factors can lead to hypertension and inflammation, including gut microbiota which plays an important role in hypertension and inflammation in humans. However, alterations to the gut microbiome and fecal metabolome, and their relationships in severe preeclampsia are not well known. This study aims to identify biomarkers significantly associated with severe preeclampsia and provide a knowledge base for treatments regulating the gut microbiome. Methods In this study, fecal samples were collected from individuals with severe preeclampsia and healthy controls for shotgun metagenomic sequencing to evaluate changes in gut microbiota composition. Quantitative polymerase chain reaction analysis was used to validate the reliability of our shotgun metagenomic sequencing results. Additionally, untargeted metabolomics analysis was performed to measure fecal metabolome concentrations. Results We identified several Lactobacillaceae that were significantly enriched in the gut of healthy controls, including Limosilactobacillus fermentum, the key biomarker distinguishing severe preeclampsia from healthy controls. Limosilactobacillus fermentum was significantly associated with shifts in KEGG Orthology (KO) genes and KEGG pathways of the gut microbiome in severe preeclampsia, such as flagellar assembly. Untargeted fecal metabolome analysis found that severe preeclampsia had higher concentrations of Phenylpropanoate and Agmatine. Increased concentrations of Phenylpropanoate and Agmatine were associated with the abundance of Limosilactobacillus fermentum. Furthermore, all metabolites with higher abundances in healthy controls were enriched in the arginine and proline metabolism pathway. Conclusion Our research indicates that changes in metabolites, possibly due to the gut microbe Limosilactobacillus fermentum, can contribute to the development of severe preeclampsia. This study provides insights into the interaction between gut microbiome and fecal metabolites and offers a basis for improving severe preeclampsia by modulating the gut microbiome.

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Section: Discussionmentioning

confidence: 99%

Landscapes of gut bacterial and fecal metabolic signatures and their relationship in severe preeclampsia

Liu,

Zeng,

et al. 2024

J Transl Med

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“…PRO-10c was reported as an AsS activator, which improves the enzyme's ability to bind to ATP and citrulline, while also raising the levels of L-arginine [25]. Elevated levels of L-arginine can enhance the synthesis of agmatine, which is known for its neuroprotective properties [47]. Agmatine blocks the N-methyl-D-aspartate (NMDA) receptor channel in hippocampuss [48].…”

Section: Neuroprotection Mediated By Venom-derived Peptidesmentioning

confidence: 99%

Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms

ALBERTO-SILVA,

SILVA

2024

BIOCELL

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Venom snake-derived peptides have multiple biochemical, pharmacological, and toxicological profiles, allowing for the discovery of new medicinal products and therapeutic applications. This review specifically examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake venom. It also includes a brief evaluation of short peptides that are being considered as potential therapeutic agents. Proline-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes, specifically Bothrops atrox, Bothrops jararaca, and Bothrops moojeni, have been shown to have pro-survival properties, the ability to reduce oxidative stress, and the ability to promote cell viability and mitochondrial functions. Three significant mechanisms are related to the neuroprotection mediated by snake venom oligopeptides: (1) Activation of the Larginine metabolite pathway, such as polyamines from ornithine metabolism, which reduces N-methyl-D-aspartate (NMDA)-type glutamate receptor activity; (2) Enhancement of cell viability by activating the nerve growth factorsignaling pathway; and (3) Activation of the Muscarinic acetylcholine receptor subtype M1 (mAChR-M1). These small peptides show promise as neuroprotective agents against a variety of neurodegenerative disorders.

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Exploring the clinical connections between epilepsy and diabetes mellitus: Promising therapeutic strategies utilizing agmatine and metformin

Nangia,

Saravanan,

Hazra

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Neuroprotection by agmatine: Possible involvement of the gut microbiome?

Cited by 6 publications

References 328 publications

Landscapes of gut bacterial and fecal metabolic signatures and their relationship in severe preeclampsia

Landscapes of gut bacterial and fecal metabolic signatures and their relationship in severe preeclampsia

Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms

Exploring the clinical connections between epilepsy and diabetes mellitus: Promising therapeutic strategies utilizing agmatine and metformin

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