Functional and pharmacological analysis of agmatine administration in different cerebral ischemia animal models

Selaković, Vesna; Arsenijevic, L.; Jovanović, Marijana; Sivcev, S.; Jovanović, Nina; Leontijevic, M.; Stojanović, Maja; Radenković, Miroslav; Anđjus, Pavle R.; Radenović, Lidija

doi:10.1016/j.brainresbull.2019.01.005

Cited by 5 publications

(4 citation statements)

References 67 publications

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“…The 2VO model is commonly used to study the pathophysiology of stroke and to test potential therapeutic interventions. It allows us to examine the effects of reduced blood flow on the brain, including the development of neuronal injury, inflammation, and impaired neurological function [2,20,21].…”

Section: Vessel Occlusion (2vo) Modelmentioning

confidence: 99%

“…This is the most widely used model and involves the temporary or permanent occlusion of the middle cerebral artery (MCAO), one of the major arteries supplying blood to the brain, first introduce by Tamura et al in 1981 [30]. This can be achieved through surgical techniques or by inserting a nylon filament or suture into the artery to block blood flow [21,31].The suture is advanced until it occludes the vessel, leading to the blockage of blood flow to the surrounding brain tissue [32]. Reperfusion can then be achieved by removing the suture after a certain period of time.…”

Section: Middle Cerebral Artery Occlusion (Mcao)mentioning

confidence: 99%

“…Neuroprotection involves interventions aimed at preserving brain tissue during ischemia, while neurorecovery focuses on promoting the repair and functional recovery of the damaged brain. Some novel therapeutic approaches include the use of neurotrophic factors, stem cell transplantation, hypothermia, and pharmacological agents that target specific pathways involved in ischemic injury [68,21,2]. These advancements offer potential interventions to improve outcomes in global cerebral ischemia patients.…”

Section: Neuroprotective Agentsmentioning

confidence: 99%

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In Vivo Experimental Models of Cerebral Ischemia: Analysis, Translational Potential and Clinical Relevance

2024

Cardiol Res Cardiovasc Med

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Despite all current efforts in the field of cerebrovascular disease prevention, stroke remains the leading cause of disability and death worldwide. Animal models are essential tools in stroke research to mitigate its devastating effects. The novelty of this review is the comprehensiveness of the approach and the detailed analysis of progress in the field, translational potential and clinical relevance. Recent research aimed to refine and enhance animal models to better mimic clinical scenario and improve reproducibility. This review provides extensive overview of its classification, underlining their key features, advantages, limitations, and advancements. Additionally, characterization and validation of ischemia models are discussed. Therapeutic strategies such as hypothermia, pharmacological interventions, genetic and molecular approaches, and cell-based therapies are highlighted. This review analyse the challenges and future directions, as well as translational potential and clinical relevance of ischemia models. Incorporating patient-derived cells and genetic modifications in animal models can provide a more personalized and clinically relevant approach. Bridging the gap is challenging and requires careful consideration of multiple factors, including appropriate dose translation, understanding species differences, and aligning protocols. Future studies should focus on optimizing the translational process and conducting well-designed clinical trials to assess the safety and efficacy of promising interventions.

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Section: Vessel Occlusion (2vo) Modelmentioning

confidence: 99%

Section: Middle Cerebral Artery Occlusion (Mcao)mentioning

confidence: 99%

Section: Neuroprotective Agentsmentioning

confidence: 99%

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In Vivo Experimental Models of Cerebral Ischemia: Analysis, Translational Potential and Clinical Relevance

2024

Cardiol Res Cardiovasc Med

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“…AG has been found in hippocampus, frontal cortex, striatum, locus coeruleus (Barua et al 2019 ; Kotagale et al 2020a , b ), amygdala, dorsal raphe nucleus (Selakovic et al 2019 ), regions associated with visceral control, neuroendocrine control, pain perception, emotion processing (Reis and Regunathan 2000 ; Selakovic et al 2019 ), cognitive functions, learning, and memory (Kotagale et al 2020b ).…”

Section: Introductionmentioning

confidence: 99%

Effects of imidazoline agents in a rat conditioned place preference model of addiction

Șorodoc

Rusu-Zota

Nechita³

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Agmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The present study aimed to evaluate the interaction between AG, IDZ, and EFR with an opiate, tramadol (TR), in a conditioned place preference (CPP) paradigm. In the experiment, we used five groups with 8 adult male Wistar rats each. During the condition session, on days 2, 4, 6, and 8, the rats received the drugs (saline, or TR, or IDZ and TR, or EFR and TR, or AG and TR) and were placed in their least preferred compartment. On days 1, 3, 5, and 7, the rats received saline in the preferred compartment. In the preconditioning, the preferred compartment was determined. In the postconditioning, the preference for one of the compartments was reevaluated. TR increased the time spent in the non-preferred compartment. AG decreased time spent in the TR-paired compartment. EFR, more than IDZ, reduced the time spent in the TR-paired compartment, but without statistical significance. AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in the TR-paired compartment, without statistical significance.

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Neuroprotection by agmatine: Possible involvement of the gut microbiome?

Saha,

Panda,

Holkar

et al. 2023

Ageing Research Reviews

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Functional and pharmacological analysis of agmatine administration in different cerebral ischemia animal models

Cited by 5 publications

References 67 publications

In Vivo Experimental Models of Cerebral Ischemia: Analysis, Translational Potential and Clinical Relevance

In Vivo Experimental Models of Cerebral Ischemia: Analysis, Translational Potential and Clinical Relevance

Effects of imidazoline agents in a rat conditioned place preference model of addiction

Neuroprotection by agmatine: Possible involvement of the gut microbiome?

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