Involvement of carbonate/bicarbonate ions in the superoxide-generating reaction of adrenaline autoxidation

Sirota, T. V.

doi:10.18097/pbmc20156101115

Cited by 19 publications

(10 citation statements)

References 29 publications

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“…The reaction of adrenaline autooxidation in the alkaline carbonate buffer was used for the determination of the SOD enzymatic activity, as a good model of the quinoid oxidation of adrenaline [29,30]. Scavenging superoxide anion-radical enzyme SOD inhibits the accumulation of adrenochrome.…”

Section: Sod-protective Activity and Pro-/antioxidant Activitymentioning

confidence: 99%

In silico and in vitro evaluation of the biological activity of some organicsulfur-containing compounds

Осипова¹,

Половинкина²,

Osipova³

et al. 2019

Turk J Chem

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generation rate decreased in the presence of the studied compounds, evidencing for their antiradical activity.Increase of superoxide dismutation activity of the biopreparation in the presence of compounds 1-10 was also shown, and this fact could indicate their ability to increase the antioxidant status and decrease the probability of oxidative stress development. It was found that compounds 1-10 did not inhibit enzyme lipoxygenase, which indicated the absence of antiinflammatory activity. The results of the forecast were consistent with the data of the experimental studies.

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Section: Sod-protective Activity and Pro-/antioxidant Activitymentioning

confidence: 99%

In silico and in vitro evaluation of the biological activity of some organicsulfur-containing compounds

Осипова¹,

Половинкина²,

Osipova³

et al. 2019

Turk J Chem

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“…The activity of SOD, which inhibited the formation of superoxide anion radical, was estimated by the literature method [24] and showed that the catalytic activity of SOD increased in the presence of both II and its complexes with I (Fig. 3).…”

Section: Lpo Processes In Blood Plasma Under Oxidative Stress In Vitrmentioning

confidence: 99%

Complexes of Glucosamine Hydrochloride and Phytic Acid in Aqueous Medium and Their Antioxidant Properties in Human Blood Plasma

et al. 2016

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The reaction in aqueous medium of phytic acid (myo-inositol hexakisphosphate) and glucosamine hydrochloride (2-amino-2-deoxy-b-D-glucopyranose hydrochloride) formed phytic acid-glucosamine complexes of formula InsP 6 × 5GA. Their compositions were proved by elemental analysis for C, H, N, and P. IR, PMR, 13 C NMR, and 31 P NMR spectroscopy and potentiometric titration showed that the complexes of phytic acid and glucosamine were formed by H-bonds and electrostatic salt interactions. High antioxidant activity against lipid peroxidation and a positive effect on superoxide dismutase activity were found for complexes of InsP 6 H 12 and glucosamine in in vitro studies of human blood plasma under oxidative stress.Metabolic disruptions of bone and connective tissues, in particular in collagen and cartilage matrices, are responsible for inflammatory and degenerative changes and are caused by the formation of reactive oxygen species, activation of lipid peroxidation (LPO), deactivation of enzymes such as superoxide dismutase (SOD), and the development of oxidative stress [1 -4].Preparations of glucosamine salts (chloride or sulfate) are known to inhibit the formation of malondialdehyde and diene conjugates, i.e., intermediate steps in the oxidation of collagen that underlie the biochemical and biophysical destruction of the cartilage matrix [5]. Multi-year experience showed that glucosamine (I) played a positive role in decreasing cartilage collagen degradation that resulted from excessive LPO and protein oxidation [6]. As a rule, preparations of I are used in combination with chondroitin in order to increase the activity of antioxidant enzymes such as SOD and catalase [7].Recently, the natural antioxidant phytic acid (myo-inositol hexakisphosphate, II, InsP 6 H 12 ) has generated much interest. It is a phosphorylated sugar that regulates metabolic processes, including Ca-P and ion balance in bone and connective tissues, and is involved in maintaining energy production in the human body [8][9][10]. It is commonly thought that the antioxidant effect of II is due mainly to inhibition of xanthine oxidase, which generates superoxide anion O 2 ·-, and activation of SOD [11]. It should be expected that II is capable not only of causing a synergic antioxidant effect in preparations of I but also of correcting more completely metabolic disruptions due to collagen-associated diseases.The goals of the present work were to study the formation in aqueous medium of complexes of I hydrochloride and II and to evaluate the antioxidant properties of the resulting complexes using parameters such as the LPO level, total antioxidant activity (AOA), and SOD activity with ozone-induced oxidative stress.

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Section: Introduction 1the Base Mechanismsmentioning

confidence: 99%

“…•− (Scheme 1) [14][15][16][17][18][19][20]. Most of the information was obtained for significant conversion depths and refers to the hypothetical gross process of adrenaline → adrenochrome transformation [12,13,[15][16][17][18]. The detailed mechanism of the quinoid process is still actively discussed in the literature, and the role of magnetic fields is considered only from the standpoint of their possible effect on oxidative stress [1,4,7,14,[18][19][20][21].…”

Section: Introduction 1the Base Mechanismsmentioning

confidence: 99%

Influence of a Constant Magnetic Field on the Mechanism of Adrenaline Oxidation

et al. 2022

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In order to establish the role of the magnetic effect in the key stages of the autoxidation and initiated oxidation radical-chain reactions, the experimental data and kinetic analysis of the influence of a magnetic field on the oxidative transformations of adrenaline are presented in this work. In the case of autoxidation, the process is being controlled by the rate of adrenaline consumption in the gross process of quinoid oxidation. The analysis of the obtained results is estimative and is based on the assumption of the leading role of superoxide radical during the autoxidation. Superoxide radical concentration increases with the increase in the applied magnetic field strength, which leads to the decrease in the rate of initiation of the quinoid process. In the case of initiated oxidation, the results obtained are based on the known radical-chain mechanism, and they were interpreted using the theory of radical pairs. The observed magnetic effect is explained by the influence of a constant magnetic field on the mechanism of chain termination of radical-chain oxidation and/or initiation of the autoxidation process.

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Involvement of carbonate/bicarbonate ions in the superoxide-generating reaction of adrenaline autoxidation

Cited by 19 publications

References 29 publications

In silico and in vitro evaluation of the biological activity of some organicsulfur-containing compounds

In silico and in vitro evaluation of the biological activity of some organicsulfur-containing compounds

Complexes of Glucosamine Hydrochloride and Phytic Acid in Aqueous Medium and Their Antioxidant Properties in Human Blood Plasma

Influence of a Constant Magnetic Field on the Mechanism of Adrenaline Oxidation

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