1981
|
Sign up to set email alerts
|

Abstract: The effects of synthetic enkephalin analog (FK 33–824) and β-endorphin on growth hormone (GH) secretion and their interaction with brain monoamines were investigated in unanesthetized male rats. Blood samples (0.4 ml each) were withdrawn every 10–20 min for 6 h from a catheter chronically implanted in the right atrium. In all control rats, immunoreactive GH secretion was pulsatile in nature and two major GH bursts were found to occur around 12.00 and 15.30.The opioid peptides were injected between bursts at 14… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
19
0

Year Published

1986
1986
2002
2002

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 47 publications
(20 citation statements)
references
References 26 publications
(20 reference statements)
1
19
0
Order By: Relevance
“…The use ofa combined in vivo/in vitro experimental design permitted the examination of individual components of this regulatory system in the same animals and also allowed an assessment of the relative importance of each in the overall impairment of GH secretion. GH secretion in the conscious rat is pulsatile with secretory bursts occurring regularly at 3-4-h intervals (17,27). The effect of thyroidectomy on spontaneous GH secretion was profound in that virtually no ultradian secretory episodes were detectable and most plasma GH levels were at or beneath the limit of detection ofthe assay.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The use ofa combined in vivo/in vitro experimental design permitted the examination of individual components of this regulatory system in the same animals and also allowed an assessment of the relative importance of each in the overall impairment of GH secretion. GH secretion in the conscious rat is pulsatile with secretory bursts occurring regularly at 3-4-h intervals (17,27). The effect of thyroidectomy on spontaneous GH secretion was profound in that virtually no ultradian secretory episodes were detectable and most plasma GH levels were at or beneath the limit of detection ofthe assay.…”
Section: Discussionmentioning
confidence: 99%
“…The animals were housed for at least 4 wk after arrival in an environmentally controlled room (lights on: 0600-1800 h, temperature: 23±1 'C), with water and food provided ad libitum. Intravenous cannulae were then implanted into the right atrium as previously described (17). After cannulation, animals were caged individually, handled and weighed daily by the same investigator, and adapted to specific blood sampling procedures (18).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Seven to ten days after serial blood collections for the determination of circulating growth hormone profiles, 3-and 12-month-old vehicle-treated and 12-month-old MSG-treated rats were administered the dopamine-␤-hydroxylase inhibitor sodium diethyldithiocarbamate trihydrate (DDC; Aldrich Chemical Co., Inc., Milwaukee, WI), which has been reported to block norepinephrine synthesis and GRF-dependent growth hormone secretion for up to 12 h (Negro-Vilar et al, 1979;Katakami et al, 1981;McCormick et al, 1985). The drug, dissolved in 0.9% NaCl at a dose of 500 mg/kg b.wt.…”
Section: Methodsmentioning
confidence: 99%
“…Anatomical studies would also support a possible action of opioids at this site. Agents tested by this route include dynorphin (19), and synthetic derivatives of enkephalin (13,14,19). Of these, a muagonist ([D-Ala,MePhe.Met(O)-ollenkephalin) (1 3, 14) and mixed delta-and mu-agonists (D-Ala-Leu-enkephalin, D-Ala-Met-enkephalin) (19) increased G H levels suggesting that mu-receptors on median eminence terminals when activated also increase GHreleasing activity in the portal circulation.…”
Section: Discussionmentioning
confidence: 99%