1986
DOI: 10.1172/jci112490
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Abstract: The effects of thyroidectomy (Tx) and thyroxine replacement (T4Rx) on pituitary growth hormone (GH) secretion and hypothalamic GH-releasing hormone (GRH) concentration were compared to define the mechanism of hypothyroid-associated GH deficiency.Thyroidectomized rats exhibited a complete loss of pulsatile GH secretion with extensive reduction in GRH responsiveness and pituitary GH content. Cultured pituitary cells from Tx rats exhibited reduced GRH sensitivity, maximal GH responsiveness, and intracellular cycl… Show more

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Cited by 106 publications
(59 citation statements)
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“…levels in all patients, hypothyroid patients did not exhibit a significant change in the urinary GH level compared to the euthyroid group. Previous studies demonstrated that spontaneous GH secretion is decreased in hypothyroid states [8,14]. The discrepancy between our data and those of earlier studies may be due to differences in the severity of the hypothyroid state, the age of patients, and the species tested.…”
Section: Discussioncontrasting
confidence: 99%
“…levels in all patients, hypothyroid patients did not exhibit a significant change in the urinary GH level compared to the euthyroid group. Previous studies demonstrated that spontaneous GH secretion is decreased in hypothyroid states [8,14]. The discrepancy between our data and those of earlier studies may be due to differences in the severity of the hypothyroid state, the age of patients, and the species tested.…”
Section: Discussioncontrasting
confidence: 99%
“…It is likely that the low thyroid hormone levels of hypothyroidism will result in a low expression of pituitary GH in species with a positive TRE in the GH gene. Indeed, in hypothyroid rats both decreased pituitary content of GH mRNA (Martinoli & Pelletier 1989, Lloyd et al 1990, Tam et al 1996 and reduced pituitary GH content (Szabo et al 1985, Katakami et al 1986, Wood et al 1987, Lloyd et al 1990, Varela et al 1991 have been reported. The lack of a decrease in GH biosynthesis and release in dogs with primary hypothyroidism may be explained by the absence of a positive TRE within the canine GH gene.…”
Section: Discussionmentioning
confidence: 96%
“…Severe hypothyroidism in rats is associated with markedly reduced circulating GH levels (Varela et al 1991, Santini et al 1993, Mizobuchi et al 1996, Tam et al 1996, Osorio et al 1998, abolished GH bursts (Takeuchi et al 1978, Katakami et al 1986, blunted GH response to GHRH (Williams et al 1985, Tam et al 1996 and decreased pituitary content of mRNA encoding for GH (Martinoli & Pelletier 1989, Lloyd et al 1990, Tam et al 1996. In addition, hypothyroidism in rats causes a reduction in pituitary GH content (Szabo et al 1985, Katakami et al 1986, Wood et al 1987, Lloyd et al 1990, Varela et al 1991, pituitary GHRH receptor mRNA (Tam et al 1996, Korytko & Cuttler 1997, hypothalamic SS content (Tam et al 1996) and hypothalamic SS mRNA (Tam et al 1996).…”
Section: Introductionmentioning
confidence: 99%
“…In hypothyroidism, the somatotrophs in the anterior pituitary show higher sensitivity to SRIF, but lower sensitivity to GHRH [39]. There have been many reports on the synthesis and secretion of GHRH in the hypothyroid state.…”
Section: Effects Of Thyroidectomy On Plasma Tsh and Gh Concentrationsmentioning
confidence: 99%