“…Severe hypothyroidism in rats is associated with markedly reduced circulating GH levels (Varela et al 1991, Santini et al 1993, Mizobuchi et al 1996, Tam et al 1996, Osorio et al 1998, abolished GH bursts (Takeuchi et al 1978, Katakami et al 1986, blunted GH response to GHRH (Williams et al 1985, Tam et al 1996 and decreased pituitary content of mRNA encoding for GH (Martinoli & Pelletier 1989, Lloyd et al 1990, Tam et al 1996. In addition, hypothyroidism in rats causes a reduction in pituitary GH content (Szabo et al 1985, Katakami et al 1986, Wood et al 1987, Lloyd et al 1990, Varela et al 1991, pituitary GHRH receptor mRNA (Tam et al 1996, Korytko & Cuttler 1997, hypothalamic SS content (Tam et al 1996) and hypothalamic SS mRNA (Tam et al 1996).…”