Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity

Abstract

Advanced glycation end products (AGEs) may play an important role in the pathogenesis of chronic diabetic complications and in the natural process of biological aging.

Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin–induced diabetic Wistar rats

“…They are also used to determine possible alterations in the levels of biomolecules such as enzymes, metabolic products, haematology, normal functioning and histomorphology of the organs [14] .…”

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

“…AGE-RAGE complex induces atherosclerosis through enhancement of the expression of VCAM-1 on endothelial cells [22]. VCAM-1 facilitates the adhesion of mononuclear proinflammatory cells, and the activation of NADPH oxidase, which finally accelerates migration of lymphocytes from stimulated cells [23]. Furthermore VCAM-1 promotes the adhesion of monocyte to endothelial cells.…”

“…Expansion of the mesangial layer due to sedimentation of protein in glomerular mesangial space, in the company of partial proliferation [31] plays a significant role in reduction of filtration via decreasing the surface area due to pressing of capillaries [32], or occlusion of capillaries [23]. The elevated level of AGEs in serum also enhances the level of transforming growth factor-b, which in turn stimulates the formation of collagen matrix, or at least in part, basal membrane thickening [30].…”

Maillard Reaction Products in Processed Food: Pros and Cons

“…Kalousová et al (2002) and most recently, Mostafa et al (2007) showed that AGEs level in plasma proteins are elevated in patients with diabetes. The high blood glucose levels favor the occurrence of spontaneous reactions (glycation) between glucose and proteins, resulting in the formation and excessive deposition of AGEs (Magalhães et al, 2008). In patients with renal failure AGEs accumulation occurs due to the decrease in the extent of degradation and elimination from the body and, also, to increased exposure to oxidative stress.…”