Invitro Antidiabetic Activities of Agar, Agarosa, and Agaropectin from Gracilaria gigas Seaweed

Hardoko, H H; Febriani, Agnes; Sirantri, Titri

doi:10.17844/jphpi.2015.18.2.128

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…The in vitro antidiabetic test results showed a difference in inhibition between the nests of A. mellifera and the nests of A. dorsata Binghami against the α-glucosidase enzyme. Differences in the inhibition of α-glucosidase enzymes indicate differences in the antidiabetic activity of each extract (Hardoko et al, 2015). The IC50 value indicates that the lower the value, the higher the potential.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

In Vitro Antidiabetic Activity and Bioactive Ingredients of Apis mellifera and Apis dorsata Binghami Nest Extracts

Sibala,

Naharia,

Manampiring

et al. 2023

JPBN

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Indonesia ranks 7th out of ten countries with diabetes mellitus, which continues to increase yearly. Honeycomb is rich in secondary metabolites formed from plant resins (propolis) which contain alkaloids, flavonoids, saponins, tannins, steroids and triterpenes. The research aimed to analyze the comparison of flavonoid content and antidiabetic activity with the enzyme α-glucosidase In Vitro nest extract of A. mellifera and A. dorsata Binghami. The samples used were nests of A. mellifera from northern Toraja, southern Sulawesi and A. dorsata Binghami from Southeast Minahasa, North Sulawesi. Using 96% ethanol, HPLC method of flavonoid testing and in vitro antidiabetic activity testing using α-glucosidase enzymes. The flavonoid content results were based on the number of peaks produced and the retention time of A. mellifera produced 26 compounds, and A. dorsata Bingham produced 21 compounds. The results of in vitro antidiabetic tests with α-glucoside enzyme inhibitors obtained IC50 values from the nest extract of A. mellifera of 3.605 mg/L and the nest extract of A. dorsata Binghami of 4.992 mg/L. The extract from A. mellifera had better antidiabetic potential than that of A. dorsata Binghami, although the difference is insignificant.

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Section: Antidiabetic Activitymentioning

confidence: 99%

In Vitro Antidiabetic Activity and Bioactive Ingredients of Apis mellifera and Apis dorsata Binghami Nest Extracts

Sibala,

Naharia,

Manampiring

et al. 2023

JPBN

View full text Add to dashboard Cite

show abstract

“…Preliminary test and inhibition of the enzyme α-glucosidase is the hydrolysis of the enzyme against p-nitrophenyl-α-D-glucopyranoside to p-nitrophenol which gives a yellow color 10 . The enzyme inhibitory activity test was carried out by spectropotometry method at a wavelength of 410 nm.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Phytochemical Screening and Antidiabetic Activity of N-Hexane, Ethyl Acetate and Water Extract from Durian Leaves (Durio Zibethinus L.)

Aruan¹,

Barus²,

Haro³

et al. 2019

Orient. J. Chem

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The leaf of Durian (Durio zibenthinus L.) contain flavonoids and steroids in ethanol extract. Natural flavonoids have an important role in the prevention of diabetes and its complications and are able to provide good effects in the fight against diabetes mellitus, either through the ability to reduce glucose absorption and improve glucose tolerance. The purpose of this research is to know the activity of antidiabetic extract of n-hexane, ethyl acetate and water from durian leaf ethanol extract. The results of phytochemical screening screen showed that durian leaf contains chemical compounds of flavonoids, steroids, and glycosides. The treatment was gradual to obtain durian leaf extract i.e. with 96% ethanol, then partitioned gradually with n-hexane and ethyl acetate. Therefore, the extract of n-hexane, ethyl acetate and water is obtained. All three extracts were tested activity antidiabetic with inhibition method of α-glucosidase enzyme activity. The inhibitory results of α-glucosidase enzyme activity showed IC 50 values for n-hexane, ethyl acetate and water extracts of 9.79 μg/mL; 38.18 μg/mL and 35.83 μg/mL. The results show that the polar chemical component of the durian leaf is potential as an antidiabetic.

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Invitro Antidiabetic Activities of Agar, Agarosa, and Agaropectin from Gracilaria gigas Seaweed

Cited by 2 publications

References 13 publications

In Vitro Antidiabetic Activity and Bioactive Ingredients of Apis mellifera and Apis dorsata Binghami Nest Extracts

In Vitro Antidiabetic Activity and Bioactive Ingredients of Apis mellifera and Apis dorsata Binghami Nest Extracts

Phytochemical Screening and Antidiabetic Activity of N-Hexane, Ethyl Acetate and Water Extract from Durian Leaves (Durio Zibethinus L.)

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