Phytochemical Screening and Antidiabetic Activity of N-Hexane, Ethyl Acetate and Water Extract from Durian Leaves (Durio Zibethinus L.)

Abstract

The leaf of Durian (Durio zibenthinus L.) contain flavonoids and steroids in ethanol extract. Natural flavonoids have an important role in the prevention of diabetes and its complications and are able to provide good effects in the fight against diabetes mellitus, either through the ability to reduce glucose absorption and improve glucose tolerance. The purpose of this research is to know the activity of antidiabetic extract of n-hexane, ethyl acetate and water from durian leaf ethanol extract. The results of phytochemical screening screen showed that durian leaf contains chemical compounds of flavonoids, steroids, and glycosides. The treatment was gradual to obtain durian leaf extract i.e. with 96% ethanol, then partitioned gradually with n-hexane and ethyl acetate. Therefore, the extract of n-hexane, ethyl acetate and water is obtained. All three extracts were tested activity antidiabetic with inhibition method of α-glucosidase enzyme activity. The inhibitory results of α-glucosidase enzyme activity showed IC 50 values for n-hexane, ethyl acetate and water extracts of 9.79 μg/mL; 38.18 μg/mL and 35.83 μg/mL. The results show that the polar chemical component of the durian leaf is potential as an antidiabetic.

Phytochemical Properties and In vitro Antimicrobial Activity of Methanolic Leaf Extract of Durio zibethinus Murr. on Selected Clinical Isolates

“…Into one tube, 1 mL of the 1 mg/mL test solution was transferred and serially diluted, ranging from 0.05 mg/mL to 0.75 mg/mL. After that, 0.1 mL of inoculum was inoculated, and the tubes were then cultured for 24…”

“…(Family Bombacaceae) is a type of tropical fruit plant called durian that has been widely cultivated in Malaysia and other Southeast Asian countries. Researchers have reported that antioxidant, anticancer, antidiabetic, antilipoxygenase, anti-heart disease, and anti-obesity properties can be attributed to durian [12,13]. One of the purported medicinal and therapeutic benefits of durian fruit is its capacity to fortify the immune system.…”

Efektivitas Ekstrak Etanol Daun Durian (Durio zibethinus (Linn.)) sebagai Antihiperurisemia

“…Senyawa fenolik juga diduga memiliki aktivitas sebagai antihiperurisemia karena mampu menghambat kerja dari enzim xantin oksidase. 8,9,10 Xantin oksidase merupakan enzim kunci pada manusia, terutama pada metabolisme purin dengan bertindak sebagai katalis reaksi hidroksilasi oksidatif hipoxantin menjadi xantin dan hasil selanjutnya adalah pembentukan asam urat. 11 Jalur ini merupakan jalur degradasi purin dengan penurunan O2 di pusat flavin dan menghasilkan Reactive Oxygen Species (ROS), baik radikal anion superoksida atau hidrogen peroksida.…”

TOXICITY AND ANTIOXIDANT ACTIVITIES OF EXTRACT OF n-HEXANE, H2O, AND ETHYL ACETATE FROM THE LEAVES OF DURIAN, Durio zibethinus L.

“…The yield of the extracts and debt to equity ration (DER) obtained from ethanol extract listed in Table-1. Screening of extract ethanol from durian leaf such as steroids/terpenoids, flavonoids, an glycosides 7 . The result of extraction and partition for samples showed that the water extract had the highest yield (7.04%) among other extracts (0.2 -0.8%).…”