Durian (Durio zibethinus Linn.) leaves are known to inhibit the xanthine oxidase enzyme which can reduce uric acid levels in the blood. The purpose of study is to determine the effectiveness of ethanol extracts of durian leaves in reducing uric acid levels in hyperuricemic mice. The mice were induced with chicken’s liver juice 0,2 mL/20 gBW and potassium oxonate 250 mg/kgBW. The animals were mice with uric acid levels above 3,3 mg/dL or 6,2-7,1 mg/dL. The study was used a completely randomized design (CRD) with six treatments and three replications, with three mice in each replications. The treatments group were K+: Allopurinol 10 mg/kgBW; K-: CMC-Na 0.5%; extracts in group P1,P2, P3, P4 are 50; 100; 200; 250 mg/kgBW. The measurements of uric acid levels were performed on day-0, day-6 after induction, and day-15 after administering each group. The data obtained were analyzed by One Way Anova test followed by Duncan's Post Hoc further test. The results showed that durian leaves could reduce uric acid levels in mice blood with the highest percentage reduction was in P2 (100 mg/kgBW) group of 40,53%, followed by P1 (50 mg/kgBW) of 38,68%. The lowest percentage was in the P4 group (250 mg/kgBW) of 22,36%, followed by the P3 group (200 mg/kgBW) of 27,71% and the ED50 value was 61,65 mg/kgBW. In conclusion, ethanol extracts of durian leaves has a significant effect on decreasing total uric acid levels in mice and has potential as an antihyperuricemia agent.

Doxorubicin is one of the chemotherapy agents that is often used in breast cancer therapy. Phenomenon of breast cancer cell resistance to chemotherapy agents has been traced to the molecular level. The development of compounds that can overcome drug resistance chemotherapy needs to be continuously developed, especially agents with specific molecular targets, namely P-glycoprotein (Pgp), NFkB, cyclin, and cyclin-dependent kinase (CDK). Another alternative is the combination of chemotherapy agents with chemopreventive agents (co-chemotherapy) to reduce side effects and increase sensitivity of cancer cells. Doxorubicin is often used in breast cancer therapy. This study was performed to determine the effect of ethanolic extract of Pinang Masak Jambi (Areca catechu L.) (EEPMJ) and doxorubicin combination on MCF-7 breast cancer cells. Cytotoxic assay of EEPMJ and doxorubicin, alone, or in combination, was done using MTT test method to determine the IC 50 and CI (Combination Index) values. The results indicated that EEPMJ and doxorubicin had IC 50 values of 75.1 µg/ml and 22 µg/ml, respectively. Based on CI values, all combination concentration showed varying CI values. The concentration of 1/8 IC 50 of EEPMJ with 1/2, 1/4, and 1/8 IC50 of doxorubicin showed a strong synergistic effect (CI 0.1-0.3), with the inhibition of cell viability up to 67.39%. This synergistic effect occurs because EEPMJ potentially could increases the cytotoxicity of doxorubicin.

Using of hand sanitizers is an important step in preventing the spread of the virus, but the proliferation of new hand sanitizers that do not meet standards demands that people choose wisely. The existence of a policy that the community may make their own hand sanitizers also needs to be balanced with an increase in people's understanding of how to make them correctly. Activity starting with coordination, preparation, implementation and evaluation through question and answer. This service was preceded by counseling about infectious diseases how to prevent them. One way to prevent it is washing hands properly. Firstly, choose soap, but if difficult to get water, a hand sanitizer is a solution. Furthermore, counseling about hand sanitizers in the form of selecting hand sanitizers according to standards, making hand sanitizers through video presentation and proper hand washing methods. Team makes hand sanitizers at the Biotechnology and Engineering Laboratory for the implementation of sterilization to labeling. The video shows the preparation stages in the form of sterilizing the equipment, measuring, mixing, filling, packaging and labeling. The community is given hand sanitizer samples as well so that people can see examples of hand sanitizer labels and important components that should be there. During the question and answer session, most of them answered correctly, were able to choose and understand hand sanitizer formulas meet standards requirement and knew how to wash their hands properly so that it was hoped that they could prevent diseases caused by viruses.

HIV atau Human Immunodeficiency Virus adalah sejenis virus yang menyerang/menginfeksi sel darah putih yang menyebabkan turunnya kekebalan tubuh manusia. Akibat menurunnya kekebalan tubuh maka orang tersebut sangat mudah terkena berbagai penyakit infeksi (infeksi oprtunistik) yang sering berkaibat fatal. Pengidap HIV memerlukan pengobatan dengan Antiretroviral (ARV) untuk menurunkan jumlah virus ARV untuk mencegah terjadinya infeksi oportunistik dengan berbagai komplikasinya. Di Jambi, persentase penularan virus HIV sudah masuk kategori yang cukup besar sehingga perlu diketahui gambaran karakteristik dari pasien HIV yang sedang menjalani pengobatan dengan terapi ARV. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik dari pasien HIV yang sedang menjalani pengobatan dengan terapi ARV di poli rawat jalan RSUD Raden Mattaher Jambi selama Januari – Juni Tahun 2018. Penelitian ini menggunakan rancangan deskriptif dengan jumlah pasien HIV yang menjalani terapi ARV sebanyak 177 orang di poli rawat jalan RSUD Raden Mattaher Jambi secara total sampling. Metode penelitian adalah cohort retrospektif. Analisa data menggunakan analisis univariat untuk memperoleh gambaran distribusi frekuensi serta proporsi dari variabel yang diteliti yaitu usia, jenis kelamin, pendidikan, pekerjaan, status pengobatan pasien, status pernikahan, rejimen terapi dan faktor resiko. Pasien HIV yang sedang menjalani pengobatan dengan terapi ARV menunjukkan persentase terbesar pada laki – laki 63,9%, berusia 25 – 49 tahun 84,9%, bekerja 63,9%, riwayat pendidikan SLTA 49,4%, pasien lama 89,9%, menikah 58,2%, dan heteroseksual 59,4% pada terapi lini pertama. Selanjutnya, persentase terbesar pada laki – laki, berusia 25 – 49 tahun, bekerja dengan riwayat pendidikan SLTA sebesar 3,2%, pasien lama 2,6%, menikah 1,3%, dan napza 1,4% pada terapi lini kedua. Pasien HIV yang menjalani terapi ARV sebagian besar berada pada tahap terapi lini pertama dengan jenis kelamin laki-laki, berusia 25 – 49 tahun yang bekerja, riwayat pendidikan minimal SLTA, faktor resiko heteroseksual dan menikah.