Investigations on organo‐tin compounds. V The preparation and antifungal properties of unsymmetrical tri‐<i>n</i>‐alkyltin acetates

Kerk, G.J.M. van der; Luijten, J. G. A.

doi:10.1002/jctb.5010060202

Cited by 56 publications

(13 citation statements)

References 2 publications

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“…For alkylorganostannanes, toxicity varies depending on the alkyl group. In general an increase in the alkyl chain length gives a decrease in toxicity [1,2,23,24]. The particular pattern for methyl, ethyl, propyl, and butyl varies with test organism.…”

Section: Resultsmentioning

confidence: 99%

Organotin Polyethers as Biomaterials

Carraher

Roner

2009

Materials

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Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synthetic diols. Included in these materials are the first water soluble organotin polymers. The organotin polyethers exhibit a wide range of biological activities. Some selectively inhibit a number of unwanted bacteria, including Staph. MRSA, and unwanted yeasts such as Candida albicans. Some also inhibit a variety of viruses including those responsible for herpes infections and smallpox. Others show good inhibition of a wide variety of cancer cell lines including cell lines associated with ovarian, colon, lung, prostrate, pancreatic and breast cancer. The synthesis, structural characterization, and biological characterization of these materials is described in this review.

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Section: Resultsmentioning

confidence: 99%

Organotin Polyethers as Biomaterials

Carraher

Roner

2009

Materials

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“…Ligand formed by reaction of benzoyl chloride with glycin presence of sodium hydroxide. The prepared complexes were characterized by elemental analysis, infrared, conductance measurements and nuclear magnetic resonance ( 1 H, 13 C and 119 Sn NMR) spectral data. From the spectral measurements, monomer structures, monodentate and tetrahedral geometry Figure 2 were proposed for the complexes prepared.…”

Section: R 3 Sncl + Lh → Et 3 N R 3 Snl + Et 3 Nhclmentioning

confidence: 99%

Synthesis and Biological Activities of Organotin (IV) Carboxylates: A Review

Hadi¹,

Jawad²,

Ahmed³

et al. 2018

SRP

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Organotin(IV) compounds have gained significant interest in both the chemical and pharmaceutical industry. Tin (IV) form stable complexes with a unique structure and physicochemical properties that are used in organic synthesis as heat stabilizers and catalysts, in drug development as biologically active agents and in other areas. This review concentrates on recent progress in the classical and convenient synthesis procedure and biological activities as antitumoral and antimicrobial agents.

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“…Significance of the X group in R 3 SnX derivatives has been reported to have minor effects on the biological activity of the compounds [2,9] unless X itself is biologically active or can assist the transport of the molecule to the active site. It has also been shown to be significant if the X group is chelated to the tin atom.…”

Section: Introductionmentioning

confidence: 99%

“…It was not until the 1950s that their toxicities were studied systematically [2,3]. The toxicity of organotins has been found to be a function of the number of organic groups attached to the tin atom, as well as to the nature of the organic group.…”

Section: Introductionmentioning

confidence: 99%