Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications

Mazumder, Kishor; Biswas, Biswajit; Mamun, Abdullah Al; Billah, Hasan; Abid, Md. Ahsan; Sarkar, Kishore Kumar; Saha, Bisti; Azom, Shorrowar; Kerr, Philip G.

doi:10.1007/s11418-021-01602-1

Cited by 9 publications

(2 citation statements)

References 43 publications

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“…SwissADME online server was utilized to analyze the physiochemical attributes (molecular weight (g/mol), number of hydrogen bond acceptors, the number of hydrogen bond donors and number of rotatable bonds), gastrointestinal absorption, blood brain barrier, number of Lipinski's violations, and drug-likeness [ 44 , 45 ]. Besides, lipophilicity and various toxicity parameters (LD 50 , hepatotoxicity, and AMES toxicity) were anticipated by using pkCSM online server [ 46 ].…”

Section: Methodsmentioning

confidence: 99%

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

Sarkar,

Mitra,

Aktaruzzaman

et al. 2024

Heliyon

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Section: Methodsmentioning

confidence: 99%

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

Sarkar,

Mitra,

Aktaruzzaman

et al. 2024

Heliyon

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“…Owing to its various pharmacological activities, this compound has sparked considerable interest in recent years [ 102 ]. In DN animal models, ursolic acid suppresses oxidative stress and inflammation [ 103 ], inhibits extracellular matrix accumulation and renal fibrosis [ 104 ], and inhibits AGEs’ formation in kidney and plasma [ 105 ].…”

Section: Bioactive Phytochemicals For Dnmentioning

confidence: 99%

A Review of Medicinal Plants with Renoprotective Activity in Diabetic Nephropathy Animal Models

Putra

Fakhrudin

Nurrochmad

et al. 2023

Life

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Diabetic nephropathy (DN), also recognized as diabetic kidney disease, is a kidney malfunction caused by diabetes mellitus. A possible contributing factor to the onset of DN is hyperglycemia. Poorly regulated hyperglycemia can damage blood vessel clusters in the kidneys, leading to kidney damage. Its treatment is difficult and expensive because its causes are extremely complex and poorly understood. Extracts from medicinal plants can be an alternative treatment for DN. The bioactive content in medicinal plants inhibits the progression of DN. This work explores the renoprotective activity and possible mechanisms of various medicinal plant extracts administered to diabetic animal models. Research articles published from 2011 to 2022 were gathered from several databases including PubMed, Scopus, ProQuest, and ScienceDirect to ensure up-to-date findings. Results showed that medicinal plant extracts ameliorated the progression of DN via the reduction in oxidative stress and suppression of inflammation, advanced glycation end-product formation, cell apoptosis, and tissue injury-related protein expression.

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Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation

et al. 2022

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Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications

Cited by 9 publications

References 43 publications

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

A Review of Medicinal Plants with Renoprotective Activity in Diabetic Nephropathy Animal Models

Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation

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