Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation

Hyun, Min Kyung; Kim, Dae Hyun; Park, Chan Hum; Noh, Sang Gyun; Choi, Sihyun; Lee, Jae Yong; Choi, Ji Hye; Park, Duhyeon; Choi, Yeon Ja; Chung, Hae Young

doi:10.1007/s00109-022-02243-x

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…It contains various chemical constituents such as volatile oil like eugenol and methyl eugenol; flavonoids like quercetin, orientin, and vicenin; triterpenic acid contains ursolic acid and luteolin; sesquiterpenes and monoterpenes like elemene and pinenes, campesterol, cholesterol, stigmasterol, sitosterol, and phenolic compound [7]. Ursolic acid is a naturally bioactive compound that possesses potential anti-diabetic activity [8]. Quercetin is an important flavonoid that has been studied for anti-diabetic activity.…”

Section: Introductionmentioning

confidence: 99%

Validated high‐performance thin‐layer chromatographic densitometric method for quantification of gallic acid, quercetin, and ursolic acid in the combined formulation of Emblica officinalis, Punica granatum Linn, and Ocimum sanctum Linn extracts

Patel,

Vasima,

Shah

et al. 2024

Separation Science Plus

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A quantitative high‐performance thin‐layer chromatography method has been developed for the estimation of three markers gallic acid, quercetin, and ursolic acid in the extracts and combined formulation of Emblica officinalis, Punica granatum Linn, and Ocimum sanctum Linn extracts. Chromatographic development was performed using precoated silica gel 60 F254 TLC plate and final optimized mobile phase as toluene:ethyl acetate:formic acid (4.5:3:0.2 v/v/v), resulting in optimum resolution with Rf of 0.29, 0.51, and 0.78 for gallic acid, quercetin, and ursolic acid, respectively. Gallic acid and quercetin were detected at 258 nm and ursolic acid at 529 nm after derivatization. All markers showed a good correlation coefficient of 0.9950 for gallic acid, 0.9953 for quercetin, and 0.9945 for ursolic acid. The accuracy and precision measured were less than 2% relative standard deviation for all markers. The mean percent recovery found for gallic acid, quercetin, and ursolic acid were within acceptable limits in formulation indicating that the excipients present have no interference. The proposed method was found to be specific, accurate, linear, precise, and robust, and can be applicable for the simultaneous estimation of gallic acid, quercetin, and ursolic acid for the analysis of individual plant extracts and herbal formulation.

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Section: Introductionmentioning

confidence: 99%

Validated high‐performance thin‐layer chromatographic densitometric method for quantification of gallic acid, quercetin, and ursolic acid in the combined formulation of Emblica officinalis, Punica granatum Linn, and Ocimum sanctum Linn extracts

Patel,

Vasima,

Shah

et al. 2024

Separation Science Plus

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“…These molecules have various biological properties, including antioxidant and anti-inflammatory activities. It has been shown that UA, OA and UAL reduce oxidative stress and inflammation, blocking the NF-kB activation, inhibiting the expression of proinflammatory genes or reducing the production of reactive oxygen species (ROS) [ [15] , [16] , [17] , [18] ].…”

Section: Introductionmentioning

confidence: 99%

RNA-seq analysis reveals modulation of inflammatory pathways by an enriched-triterpene natural extract in mouse and human macrophage cell lines

Mejia-Garcia,

Fernandez,

Echeverri

et al. 2024

Heliyon

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Ursolic acid: biological functions and application in animal husbandry

Liu,

Qin,

Cheng

et al. 2023

Front. Vet. Sci.

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Ursolic acid (UA) is a plant-derived pentacyclic triterpenoid with 30 carbon atoms. UA has anti-inflammatory, antioxidative, antimicrobial, hepato-protective, anticancer, and other biological activities. Most studies on the biological functions of UA have been performed in mammalian cell (in vitro) and rodent (in vivo) models. UA is used in animal husbandry as an anti-inflammatory and antiviral agent, as well as for enhancing the integrity of the intestinal barrier. Although UA has been shown to have significant in vitro bacteriostatic effects, it is rarely used in animal nutrition. The use of UA as a substitute for oral antibiotics or as a novel feed additive in animal husbandry should be considered. This review summarizes the available data on the biological functions of UA and its applications in animal husbandry.

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Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation

Cited by 6 publications

References 38 publications

Validated high‐performance thin‐layer chromatographic densitometric method for quantification of gallic acid, quercetin, and ursolic acid in the combined formulation of Emblica officinalis, Punica granatum Linn, and Ocimum sanctum Linn extracts

Validated high‐performance thin‐layer chromatographic densitometric method for quantification of gallic acid, quercetin, and ursolic acid in the combined formulation of Emblica officinalis, Punica granatum Linn, and Ocimum sanctum Linn extracts

RNA-seq analysis reveals modulation of inflammatory pathways by an enriched-triterpene natural extract in mouse and human macrophage cell lines

Ursolic acid: biological functions and application in animal husbandry

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