Investigations into Ti–(Nb,Ta)–Fe alloys for biomedical applications

Biesiekierski, Arne; Lin, Jixing; Li, Yuncang; Ping, Dehai; Yamabe‐Mitarai, Yoko; Wen, Cuié

doi:10.1016/j.actbio.2015.12.010

Cited by 69 publications

(37 citation statements)

References 41 publications

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“…As the elastic modulus of Ti-6Al-4V alloy easily causes stress shielding, affecting the health of patients [2]. In recent years, as alternatives to Ti-6Al-4V alloys, non-toxic titanium alloys with lower elastic modulus and without containing the elements Al and V like Ti-Nb [16][17][18][19][20], Ti-Fe [21,22], Ti-Mo [23,24], Ti-Ta [25], Ti-Zr [26,27]-based alloys were reported. Among them, the Ti-Nb-based alloys have low elastic modulus, shape memory behavior, and hyperelasticity, so they are favored by biomedical materials researchers [16][17][18][19][20][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Microstructural and Mechanical Properties of β-Type Ti–Nb–Sn Biomedical Alloys with Low Elastic Modulus

Wang

et al. 2019

Metals

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The microstructural and mechanical properties of β-type Ti85-xNb10+xSn5 (x = 0, 3, 6, 10 at.%) alloys with low elastic modulus were investigated. The experimental results show that the Ti85Nb10Sn5 and Ti75Nb20Sn5 alloys are composed of simple α and β phases, respectively; the Ti82Nb13Sn5 and Ti79Nb16Sn5 alloys are composed of β and α″ phases. The content of martensite phase decreases with the increase of Nb content. The Ti82Nb13Sn5 and Ti79Nb16Sn5 alloys show an inverse martensitic phase transition during heating. The Ti85Nb10Sn5 and Ti82Nb13Sn5 alloys with the small residual strain exhibit the good superelastic properties in 10-time cyclic loading. The reduced elastic modulus (Er) of the Ti75Nb20Sn5 alloy (61 GPa) measured by using the nanoindentation technique is 2–6 times of that of human bone (10–30 GPa), and is smaller than that of commercial Ti-6Al-4V biomedical alloy (120 GPa). The Ti75Nb20Sn5 alloy can be considered as a novel biomedical alloy. The wear resistance (H/Er) and anti-wear capability (H3/Er2) values of the four alloys are higher than those of the CP–Ti alloy (0.0238), which indicates that the present alloys have good wear resistance and anti-wear capability.

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Section: Introductionmentioning

confidence: 99%

Microstructural and Mechanical Properties of β-Type Ti–Nb–Sn Biomedical Alloys with Low Elastic Modulus

Wang

et al. 2019

Metals

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“…As these low Fe contents more strongly affect β-Ti (bcc) phase stabilization [12], the solubility of Fe in β-Ti (both bcc structures) causes simple solution strengthening, while additions above 2 wt% Fe significantly increase strength [13]. However, the significant biocompatibility of the different alloys containing Fe has been reported in numerous studies and does not sacrifice the biochemical suitability of alloys [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties and the Microstructure of β Ti-35Nb-10Ta-xFe Alloys Obtained by Powder Metallurgy for Biomedical Applications

Amigó

Vicente

Afonso

et al. 2019

Metals

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Titanium alloys with high refractory metals content are required to obtain advanced biomaterials with a low elastic modulus and good mechanical properties. This work studies the influence of Fe content on the microstructure and mechanical properties of powder metallurgy Ti35Nb10Ta(Fe) alloys, with Fe content additions of 1.5, 3.0 and 4.5 wt%. Samples are obtained by uniaxial compaction and sintering at 1250 °C and 1300 °C. Microstructural characterization is performed by scanning and transmission electron microscopy and mechanical characterization by bending, compression and a hardness test. The elastic modulus is measured by the ultrasounds technique. The results show a 10% increase in the maximum bending strength with an increase in the sintering temperature. The obtained microstructure is composed of β-Ti phase (bcc) and some regions where laths of the α-Ti (hcp) phase occur along the grain boundaries. Fe addition slightly improves the stability of the β-Ti phase and conversely decreases the maximum strength and final deformability due to increased porosity. The Ti35Nb10Ta alloy composition displays better properties, with an elastic modulus of 75 GPa, a bending strength of 853 MPa and compression strength of 1000 MPa.

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“…8 Besides, Zr and Nb are also reported to improve the strength of Ti-based alloy. Considering that β-type titanium alloy owns lower Young's modulus compared with those αor α+β-type titanium alloys, 4-7 novel titanium alloys with β phase-stable elements including Nb, Sn, and Zr are fabricated.…”

Section: Introductionmentioning

confidence: 99%

“…Considering that β-type titanium alloy owns lower Young's modulus compared with those αor α+β-type titanium alloys, [4][5][6][7] novel titanium alloys with β phase-stable elements including Nb, Sn, and Zr are fabricated. 8 Besides, Zr and Nb are also reported to improve the strength of Ti-based alloy. 9,10 Moreover, Daniel et al found Zr and Nb could form a passive bilayer film on the surface of Ti-15Zr-5Nb alloy, resulting in low corrosion rates and corresponding ion release rates that beneficial for its biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Novel ultrafine‐grained β‐type Ti–28Nb–2Zr–8Sn alloy for biomedical applications

Zhang

Guo

et al. 2019

J Biomedical Materials Res

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Titanium alloys are widely accepted as orthopedic or dental implant materials in the medical field. It is important to evaluate the biocompatibility of an implant material prior to use. A new β‐type ultrafine‐grained Ti–28Nb–2Zr–8Sn (TNZS) alloy with low Young's modulus of 31.6 GPa was fabricated. This study aims to evaluate the biocompatibility of TNZS alloy. In this study, we examined the microstructure, chemical composition and surface wettability of the TNZS alloy. The mouse embryonic osteoblast MC3T3‐E1 cells and human umbilical vein endothelial cells (HUVECs) were cultured to study the cytocompatibility of TNZS alloy. Also, we evaluated the proinflammatory response of TNZS alloy in vitro and in vivo. The results show that the TNZS did not cause cytotoxicity, genotoxicity to MC3T3‐E1 cells and HUVECs. Whereas, the TNZS alloy could significantly promote the cell proliferation, cell spreading and cell adhesion of MC3T3‐E1 cells and HUVECs, as well as facilitate the osteogenic differentiation of MC3T3‐E1 cells. Moreover, the TNZS alloy did not induce any remarkable proinflammatory response in vitro and in vivo. Thus, the novel TNZS alloy with an elasticity closer to that of human bone is biologically safe and could be a potential candidate for biomedical implant application. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1628–1639, 2019.

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Investigations into Ti–(Nb,Ta)–Fe alloys for biomedical applications

Cited by 69 publications

References 41 publications

Microstructural and Mechanical Properties of β-Type Ti–Nb–Sn Biomedical Alloys with Low Elastic Modulus

Microstructural and Mechanical Properties of β-Type Ti–Nb–Sn Biomedical Alloys with Low Elastic Modulus

Mechanical Properties and the Microstructure of β Ti-35Nb-10Ta-xFe Alloys Obtained by Powder Metallurgy for Biomedical Applications

Novel ultrafine‐grained β‐type Ti–28Nb–2Zr–8Sn alloy for biomedical applications

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