Investigation on silver doped B2O3 – SiO2 – P2O5 – Na2O – CaO bioglass system for biomedical applications

Krishnamacharyulu, N.; Mohini, G. Jagan; Baskaran, G. Sahaya; Kumar, V. Ravi; Veeraiah, N.

doi:10.1016/j.jallcom.2017.10.271

Cited by 26 publications

(7 citation statements)

References 53 publications

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“…Bioglasses (BGs) with the chemical position of (SiO 2 ‐P 2 O 5 ‐CaO) in the different shapes of powder, coating, scaffolds, and compact construct, because of having high bioactivity index, can provide the osseointegration between implants and bone tissues by the formation of the surface apatite layers 10 . The positive effect of adding low concentration of metallic ions such as magnesium, 11 silver, 12,13 copper, 14 strontium, 15 cerium (Ce), 16–18 and lanthanum 19 into BG structure have been reported. The incorporation of Ce as a rare earth metal into the BG structure enhances the proliferation, differentiation, and mineralization of primary osteoblasts 20 .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Sahrapeyma

Asefnejad

Azami

et al. 2021

J of Applied Polymer Sci

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Novel nanosized designed ceramic powders, cerium (Ce) doped bioglass (BG) with various doped Ce content, were synthesized by sol-gel method in order to be employed in the development of PCL fibrous scaffold for bone tissue engineering applications. Characterization techniques such as X-ray diffraction analysis, transmission electron microscopy, Fourier transform infrared spectroscopy, and energy-dispersive X-ray spectroscopy were employed to evaluate the developed Ce doped BG powders. The results confirmed successful doping of Ce inside BG structure. 0, 1, 3, and 10 wt% Ce doped 58S BG were successfully encapsulated in the collagen microspheres by water-in-oil emulsion method and the average particle size and hydrodynamic diameter of microspheres were determined using scanning electron microscopy and dynamic light scattering analysis, respectively. Next, 0, 1, 3, and 10 wt% Ce doped 58S BG encapsulated collagen microspheres were loaded inside the Poly(ϵ-caprolactone) fibrous scaf-

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Section: Introductionmentioning

confidence: 99%

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Sahrapeyma

Asefnejad

Azami

et al. 2021

J of Applied Polymer Sci

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“…Several researches have shown that silver has a considerable influence on the structure and performance of bioactive glasses. Krishnamacharyulu et al [164] synthesized bioactive boro silica phosphate glasses doped with Ag 2 O. Results from visible spectroscopy, Ultraviolet, and FTIR revealed that the glass network is more disordered due to the presence of silver, leading to the appearance of more non-bridging oxygen, and Ag 2 O as a network modifier converts the boron atoms from triple coordination to quadruple coordination with oxygen.…”

Section: Silver In Bioactive Glassesmentioning

confidence: 99%

Silver‐Containing Biomaterials for Biomedical Hard Tissue Implants

Shao

Zhang

Gong

et al. 2023

Adv Healthcare Materials

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Bacterial infection caused by biomaterials is a very serious problem in the clinical treatment of implants. The emergence of antibiotic resistance has prompted other antibacterial agents to replace traditional antibiotics. Silver is rapidly developing as an antibacterial candidate material to inhibit bone infections due to its significant advantages such as high antibacterial timeliness, high antibacterial efficiency, and less susceptibility to bacterial resistance. However, silver has strong cytotoxicity, which can cause inflammatory reactions and oxidative stress, thereby destroying tissue regeneration, making the application of silver‐containing biomaterials extremely challenging. In this paper, the application of silver in biomaterials is reviewed, focusing on the following three issues: 1) how to ensure the excellent antibacterial properties of silver, and not easy to cause bacterial resistance; 2) how to choose the appropriate method to combine silver with biomaterials; 3) how to make silver‐containing biomaterials in hard tissue implants have further research. Following a brief introduction, the discussion focuses on the application of silver‐containing biomaterials, with an emphasis on the effects of silver on the physicochemical properties, structural properties, and biological properties of biomaterials. Finally, the review concludes with the authors’ perspectives on the challenges and future directions of silver in commercialization and in‐depth research.

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“…Glasses based on borate have also been effectively utilized as substrates for bone infection treatment given that they can be overloaded with antibacterial drugs, for instance, gentamicin [11], vancomycin [12], and teicoplanin [13][14][15]. Additionally, more recent research into the potential uses of glasses made of borate has included soft tissue applications like nerve restoration [16,17] and wound healing [11,[18][19][20]. A signi cant number of research investigations have been conducted on the development of bioactive glasses, and they have demonstrated that these glasses can be used to replace, regenerate, or repair injured body components.…”

Section: Introductionmentioning

confidence: 99%

Improving the physical and optical characteristics of Zinc doped borate glass for bone replacement

Salatein,

Abdelghany,

Fahim

et al. 2023

Preprint

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The presented study explores the potential of zinc-doped modified borate glass as a biomaterial for bone bonding applications. The glass samples were prepared using a melt quenching technique with a definite composition of (45-x) B2O3–24.5Na2O–24.5CaO–6P2O5–xZnO, where x = 1, 2, 5, 7.5, and 10 (wt %) and soaked in simulated body fluid (SBF) for extended periods to explore their suitability for bone bonding applications. The samples were analyzed for their structural, optical, and bioactive properties. XRD and FTIR analysis were used to examine the structural properties of the samples before and after immersion in SBF. The XRD analysis revealed that increasing the Zn content and immersion time led to the formation of a hydroxyapatite (HA) layer inside the glassy matrix, indicating improved bioactivity. The FTIR analysis showed that the addition of ZnO allowed for the conversion of tetrahedral borate units to corresponding triangular units, which improved bioactivity. Electronic spectrum measurements (UV/Vis) were used to assess the samples' optical characteristics, showing that increasing Zn content decreases the optical energy gap, indicating improved optical properties. In conclusion, this study highlights the potential of zinc-doped borate glass as a promising biomaterial for bone replacement applications. The findings indicate that by varying the Zn content, it is possible to improve the physical and optical characteristics of the glass, making it a more viable option for bone replacement. Further research is needed to optimize the composition and properties of zinc-doped borate glass and to assess its long-term performance in vivo.

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Investigation on silver doped B2O3 – SiO2 – P2O5 – Na2O – CaO bioglass system for biomedical applications

Cited by 26 publications

References 53 publications

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Fabrication of fibrous poly (ɛ‐caprolactone) nano‐fibers containing cerium doped‐bioglasses nanoparticles encapsulated collagen

Silver‐Containing Biomaterials for Biomedical Hard Tissue Implants

Improving the physical and optical characteristics of Zinc doped borate glass for bone replacement

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