Investigation on pharmacological activities of secondary metabolite extracted from a mangrove associated actinobacterium Streptomyces olivaceus (MSU3)

Sanjivkumar, Muthusamy; Babu, D. Ramesh; Suganya, A.; Selvan, Silambarasan Tamil; Balagurunathan, Ramasamy; Immanuel, G.

doi:10.1016/j.bcab.2016.03.001

Cited by 17 publications

(11 citation statements)

References 18 publications

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“…Similarly, numerous mangrove‐derived strains of Streptomyces sp. with potential to produce antioxidants also have been reported previously (Law, Ser, Duangjai, et al, ; Law, Ser, Khan, et al, ; Sanjivkumar et al, ; Tan et al, ). Therefore, this study reports the isolation of a Streptomyces sp.…”

Section: Introductionsupporting

confidence: 74%

Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

et al. 2019

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Microbial natural products serve as a good source for antioxidants. The mangrove‐derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants and UV‐protective agents. Identification and characterization methods determine that strain MUM273b belongs to the genus Streptomyces. The MUM273b extract exhibits antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging activities and also metal‐chelating activity. The MUM273b extract was also shown to inhibit the production of malondialdehyde in metal‐induced lipid peroxidation. Strong correlation between the antioxidant activities and the total phenolic content of MUM273b extract was shown. In addition, MUM273b extract exhibited cytoprotective effect on the UVB‐induced cell death in HaCaT keratinocytes. Gas chromatography–mass spectrometry analysis detected phenolics, pyrrole, pyrazine, ester, and cyclic dipeptides in MUM273b extract. In summary, Streptomyces MUM273b extract portrays an exciting avenue for future antioxidative drugs and cosmeceuticals development.

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Section: Introductionsupporting

confidence: 74%

Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

et al. 2019

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“…Previous reports demonstrated that the methanolic extracts from the different strains of mangrove-derived Streptomyces sp. exhibited antioxidant activities, including ABTS free radical scavenging activity, DPPH free radical scavenging activity, metal chelating activity and/or a superoxide dismutase-like activity [36][37][38]40]. These findings revealed that mangrove-derived Streptomyces can produce a diverse range of antioxidant metabolites via several chemical mechanisms.…”

Section: Discussionmentioning

confidence: 85%

“…The current study results showed that the TCH4 extract had total phenolic and total flavonoid contents of 107.202.57 mg GAE/g dry extract and 44.910.84 mg QE/g dry extract, respectively. The total phenolic content of the ethyl acetate extract of mangrove-associated Streptomyces olivaceus (MSU3) contained 0.0421 mg GAE/g of dry weight of extract [36]. In addition, several studies showed a correlation between the antioxidant activity and the total phenolic content in the methanolic extract of different strains of mangrove-derived Streptomyces [30,37,38].…”

Section: Discussionmentioning

confidence: 99%

“…These results showed that the TCH4 extract had potential in vitro antioxidant activity. It was reported [36] that the in vitro antioxidant activity of the ethyl acetate extract of S. olivaceus (MSU3) isolated from mangrove sediment showed DPPH scavenging activity, a reducing power effect, hydroxyl radical scavenging activity and nitric oxide activity, with IC50 values of 75.21, 39.75, 71.46 and 48.02 mg/mL, respectively. Similarly, the crude ethyl acetate extract of isolated S. coelicoflavus BC 01 from mangrove soil had a DPPH scavenging activity of 68.91%, a FRAP value of 78.00 µM/mL of ascorbic acid equivalent, and a total antioxidant capacity value of 93.33 µg/mL of ascorbic acid equivalent at 20 µg/mL concentration [39].…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial, antioxidant, cytotoxic effects and GC-MS analysis of mangrove-derived Streptomyces achromogenes TCH4 extract

Tangjitjaroenkun

Pluempanupat

Tangchitcharoenkhul

et al. 2021

Arch biol sci (Beogr)

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The in vitro biological activities of the ethyl acetate extract of the culture filtrate from Streptomyces achromogenes TCH4 (TCH4 extract) were evaluated. The ethyl acetate extract of TCH4 produced a bacteriostatic effect against Enterobacter cloacae, Staphylococcus aureus, Staphylococcus saprophyticus, Bacillus subtilis, methicillin-resistant S. aureus (MRSA) and Klebsiella pneumoniae. The extract had bactericidal activity against S. aureus, S. saprophyticus, S. aureus (MRSA) and K. pneumoniae with minimum bactericidal concentration (MBC) values in the range of 500-1000 ?g/mL. The total phenolic and flavonoid contents in TCH4 were 107.20?2.57 mg gallic acid equivalent (GAE)/g and 44.91?0.84 mg quercetin equivalent (QE)/g of dry extract. Antioxidant activity was determined by DPPH radical (IC50 299.64?6.83 ?g/mL) and ABTS radical scavenging (IC50 65.53?0.95 ?g/mL), and the ferric-reducing antioxidant power (FRAP) (822.76?9.12 mM FeSO4.7H2O/g dry extract) assays. TCH4 exhibited cytotoxic activity in the DU-145 cell line (IC50 9.36?0.37 ?g/mL). Analysis of extract constituents by GC-MS revealed pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl) (36.85%), benzeneacetamide (23.76%), and deferoxamine (12.85%) as the major compounds, which have been reported to possess pharmaceutical properties. S. achromogenes TCH4 could be a potential source of bioactive metabolites with antibacterial, antioxidant and anticancer activities for pharmaceutical applications.

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“…Furthermore, along with the recent isolation of novel Streptomyces species from mangrove soil such as S. colonosanans [ 31 ], S. antioxidans [ 32 ], S. malaysiense [ 32 ], S. humi [ 33 ], and S. euryhalinus [ 34 ], numerous mangrove derived Streptomyces spp. were shown previously to produce antioxidants [ 31 , 35 , 36 ]. Thus, mangrove derived Streptomyces portrays an important reservoir for bioprospecting of novel and interesting chemical scaffolds with bioactivities.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil

Tan

Chan

et al. 2018

BioMed Research International

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Mangrove derived microorganisms constitute a rich bioresource for bioprospecting of bioactive natural products. This study explored the antioxidant potentials of Streptomyces bacteria derived from mangrove soil. Based on 16S rRNA phylogenetic analysis, strain MUM292 was identified as the genus Streptomyces. Strain MUM292 showed the highest 16S rRNA gene sequence similarity of 99.54% with S. griseoruber NBRC12873T. Furthermore, strain MUM292 was also characterized and showed phenotypic characteristics consistent with Streptomyces bacteria. Fermentation and extraction were performed to obtain the MUM292 extract containing the secondary metabolites of strain MUM292. The extract displayed promising antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging and also metal-chelating activities. The process of lipid peroxidation in lipid-rich product was also retarded by MUM292 extract and resulted in reduced MDA production. The potential bioactive constituents of MUM292 extract were investigated using GC-MS and preliminary detection showed the presence of pyrazine, pyrrole, cyclic dipeptides, and phenolic compound in MUM292 extract. This work demonstrates that Streptomyces MUM292 can be a potential antioxidant resource for food and pharmaceutical industries.

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Investigation on pharmacological activities of secondary metabolite extracted from a mangrove associated actinobacterium Streptomyces olivaceus (MSU3)

Cited by 17 publications

References 18 publications

Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

Antibacterial, antioxidant, cytotoxic effects and GC-MS analysis of mangrove-derived Streptomyces achromogenes TCH4 extract

Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil

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