Investigation on Microecology of Hair Root Fungi in Androgenetic Alopecia Patients

Huang, J W; Ran, Yuping; Pradhan, Sushmita; Yan, Wei; Dai, Yong

doi:10.1007/s11046-019-00345-8

Cited by 14 publications

(10 citation statements)

References 19 publications

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“…An increased abundance of both Malassezia restricta and M. globosa has recently been reported in alopecic vertex areas compared with occipital skin and healthy controls (Table 2). 149 Further, recent 16S rRNA sequencing data have suggested that miniaturized vertex HFs in patients with androgenetic alopecia harbour increased P. acnes populations (Table 2). 31 It now needs to be elucidated whether these HF microbiome alterations are functionally relevant, e.g.…”

Section: Dysbiosis Of the Human Hair Follicle Microbiome And Associated Hair Diseasesmentioning

confidence: 98%

Exploring the human hair follicle microbiome*

et al. 2021

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Section: Dysbiosis Of the Human Hair Follicle Microbiome And Associated Hair Diseasesmentioning

confidence: 98%

Exploring the human hair follicle microbiome*

et al. 2021

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“…Similarly, Trichosporon and Malassezia were associated with the fungal microbiota of the hepatopancreas and intestine of L. vannamei (Boone, 1931). In humans, Trichosporon is the etiological agent of white piedra, benign superficial lesions, but which can spread (Huang et al, 2019). It can also be associated with urinary disorders and esophagitis (Francisco et al, 2019;Méndez-Tovar et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Counting and identification of molds and yeasts in dry salted shrimp commercialized in Rio Branco, Acre, Brazil

et al. 2021

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“…In a recent study, Huang et al . [28] suggested that Malassezia species contain a small amount of proteases, inducing hair loss. However, contrary to these authors, we noted in our study, a significant higher abundance of M. restricta and M. globosa in healthy subjects as also reported by Grimshaw et al .…”

Section: Discussionmentioning

confidence: 99%

“…Jo et al [27] hypothesized a protective effect due to increased Malassezia colonization in adults, preventing colonization by more pathogenic species, specifically dermatophytes. In a recent study, Huang et al [28] suggested that Malassezia species contain a small amount of proteases, inducing hair loss. However, contrary to these authors, we noted in our study, a significant higher abundance of M. restricta and M. globosa in healthy subjects as also reported by Grimshaw et al [22].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of healthy and androgenetic alopecia scalp microbiome: Effect of Lindera strychnifolia roots extract as a natural solution for its modulation

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et al. 2020

Intern J of Cosmetic Sci

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The human scalp harbours a vast community of microbiotal mutualists. Androgenetic alopecia (AGA), the most common form of hair loss in males, is a multifactorial condition involving genetic predisposition and hormonal changes. The role of microflora during hair loss remains to be understood. After having characterized the scalp microbiota of 12 healthy male subjects and 12 AGA male subjects (D0), the aim of this investigation was to evaluate the capacity of Lindera strychnifolia root extract (LsR) to restore a healthy bacterial and fungal scalp microflora after 83 days (D83) of treatment. MATERIAL AND METHODS: The strategy used was based on high-throughput DNA sequencing targeting the encoding 16S ribosomal RNA for bacteria and Internal Transcribed Spacer 1 ribosomal DNA for fungi. RESULTS: Test analysis of relative abundance comparing healthy and AGA subjects showed a significant increase of Cutibacterim acnes (P < 0.05) and Stenotrophomonas geniculata (P < 0.01) in AGA subjects. AGA scalp condition was also associated with a significant (P < 0.05) decrease of Staphylococcus epidermidis relative abundance. A lower proportion of Malassezia genus in samples corresponding to AGA scalps and an increase of other bacterial genera (Wallemia, Eurotium) were also noted. At the species level, mean relative abundance of Malassezia restricta and Malassezia globosa were significantly lower (P < 0.05) in the AGA group. Eighty-three days of treatment induced a significant decrease in the relative abundance of C. acnes (P < 0.05) and S. geniculata (P < 0.01). S. epidermidis increased significantly (P < 0.05). At the same time, LsR treatment induced a significant increase in the proportion of M. restricta and M. globosa (P < 0.05). CONCLUSION: Data from sequencing profiling of the scalp microbiota strongly support a different microbial composition of scalp between control and AGA populations. Findings suggest that LsR extract may be a potential remedy for scalp microbiota re-equilibrium. Resume OBJECTIF: Le cuir chevelu humain abrite une vaste communauté microbienne. L'alopécie androgénétique (AGA), la forme la plus courante de perte de cheveux chez l'homme, est une pathologie multifactorielle impliquant une prédisposition génétique et des changements hormonaux. Le rôle de la microflore lors de la chute des cheveux resteà comprendre. Après avoir caractérisé le microbiote du cuir chevelu de 12 hommes sans alopecie et 12 hommes porteur d'une alopécie, (J0), l'objectif de cetteétudeétait d'évaluer la capacité de l'extrait de racine de Lindera strychnifolia (LsR)à restaurer une microflore bactérienne et fongique saine du cuir chevelu après 83 jours (D83) de traitement. MATÉRIEL ET MÉTHODES: La stratégie utiliséeétait basée sur un séquençage d'ADNà haut débit ciblant l'ARN ribosomal 16S codant pour les bactéries et l'ADN ribosomal de l'espaceur transcrit interne 1 pour les champignons. RÉSULTATS: Une augmentation significative de Cutibacterim acnes (P < 0,05) et Stenotrophomonas geniculata (P < 0,01) chez les sujets AGA a ete note a ...

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Investigation on Microecology of Hair Root Fungi in Androgenetic Alopecia Patients

Cited by 14 publications

References 19 publications

Exploring the human hair follicle microbiome*

Exploring the human hair follicle microbiome*

Counting and identification of molds and yeasts in dry salted shrimp commercialized in Rio Branco, Acre, Brazil

Characteristics of healthy and androgenetic alopecia scalp microbiome: Effect of Lindera strychnifolia roots extract as a natural solution for its modulation

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