Investigation on antibacterial and hemolytic properties of magnesium-doped hydroxyapatite nanocomposite

Jenifer, Anthonisamy Anthoni; Senthilarasan, K.; Arumugam, S.; Sivaprakash, P.; Sagadevan, Suresh; Sakthivel, P.

doi:10.1016/j.cplett.2021.138539

Cited by 32 publications

(22 citation statements)

References 29 publications

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“…The results showed t10 hat the antibacterial activity reached around 15.12 ± 0.10 mm and 14.23 ± 0.42 mm against S. aureus, Streptococcus mitis (S. mitis), respectively [72]. Further, modified HAP with Magnesium ions led to promoting antibacterial activity against E. coli and S. aureus whereas the highest activity achieved about 10.3 and 10.0 mm respectively [73].…”

Section: Antibacterialmentioning

confidence: 99%

Nanoarchitectonics of Hydroxyapatite/Molybdenum Trioxide/Graphene Oxide Composite for Efficient Antibacterial Activity

El‐Naggar

Ali

Saleh

et al. 2021

J Inorg Organomet Polym

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Nanocomposites based on hydroxyapatite (HAP), including MoO 3 , HAP/MoO 3 , HAP/GO and HAP/MoO 3 /GO have been studied to be suggested for biological usage. The different compositions were investigated using FTIR, XRD, EDS, and XPS analysis. The tight relation between morphological features and composites' chemical ingredients was also studied. According to TEM micrographs, it was mentioned that the disappearance of well-defined grains after the combinations of HAP and MoO 3 , while graphene oxide (GO) caused a reduction in size and maintaining the particles' shape. The combination between HAP/MoO 3 declines the roughness of both HAP and MoO 3 individually, recording 27.5 nm, while HAP/GO and HAP/MoO3/GO exhibit in-between roughness average (Ra) value among its raw constituents with 34.7 and 33.5 nm, respectively. Furthermore, SEM micrographs and roughness results show how to tailing the proper features for the proposed application by changing the type and amount of additives into HAP. Thus, the composite (HAP/MoO 3 /GO) displays the uppermost cell viability compared with the rest compositions with 97.8 ± 3.0%. Additionally, this triple composite hits the peak germicidal behavior with 17.9 ± 1.2 and 16.5 ± 0.9 mm against both E.coli and S.aureus, respectively.

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Section: Antibacterialmentioning

confidence: 99%

Nanoarchitectonics of Hydroxyapatite/Molybdenum Trioxide/Graphene Oxide Composite for Efficient Antibacterial Activity

El‐Naggar

Ali

Saleh

et al. 2021

J Inorg Organomet Polym

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“…Mg play an important role in the metabolism of the minerals into the muscle, nervous system and bones of the human body. Mg represents the main substitutes of calcium in the bone apatite structure being present in the human bones and teeth in a percentage higher than 50% [6][7][8]. The lack of Mg leads to the slowdown of bone development, osteoporosis, and reduces the activity of osteoblasts, osteoclasts and osteopenia cells [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…The incorporation of Mg 2+ ions into the hydroxyapatite structure changes the crystalline parameters of the synthesized compounds. These materials proved to be very helpful for bone mineralization by reducing bone fragility and enhancing the calcification process [8]. Nevertheless, the concentration of Mg 2+ ions in Mg-doped hydroxyapatite powders needs to be carefully assessed in order to prevent toxicity to the human cells and any possible hemolytic activity [6,8].…”

Section: Introductionmentioning

confidence: 99%

“…These materials proved to be very helpful for bone mineralization by reducing bone fragility and enhancing the calcification process [8]. Nevertheless, the concentration of Mg 2+ ions in Mg-doped hydroxyapatite powders needs to be carefully assessed in order to prevent toxicity to the human cells and any possible hemolytic activity [6,8]. Mg-doped hydroxyapatite powders have been produced by: sol-gel [6][7][8], co-precipitation [6], microwave-assisted wet chemical [8] or mechanochemical [9] synthesis methods.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the concentration of Mg 2+ ions in Mg-doped hydroxyapatite powders needs to be carefully assessed in order to prevent toxicity to the human cells and any possible hemolytic activity [6,8]. Mg-doped hydroxyapatite powders have been produced by: sol-gel [6][7][8], co-precipitation [6], microwave-assisted wet chemical [8] or mechanochemical [9] synthesis methods. The synthesis of chitosan with Mg-doped hydroxyapatite can lead to the improvement of the final compound biocompatibility, bone regeneration, and antimicrobial properties [6,7].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Electron Beam Irradiation on the Morphological and Physicochemical Properties of Magnesium-Doped Hydroxyapatite/Chitosan Composite Coatings

et al. 2022

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This work reports on the influence of 5 MeV electron beam radiations on the morphological features and chemical structure of magnesium-doped hydroxyapatite/chitosan composite coatings generated by the magnetron sputtering technique. The exposure to ionizing radiation in a linear electron accelerator dedicated to medical use has been performed in a controllable manner by delivering up to 50 Gy radiation dose in fractions of 2 Gy radiation dose per 40 s. After the irradiation with electron beams, the surface of layers became nano-size structured. The partial detachment of irradiated layers from the substrates has been revealed only after visualizing their cross sections by scanning electron microscopy. The energy dispersive X-ray spectral analysis of layer cross-sections indicated that the distribution of chemical elements in the samples depends on the radiation dose. The X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and X-ray diffraction analysis have shown that the physicochemical processes induced by the ionizing radiation in the magnesium doped hydroxyapatite/chitosan composite coatings do not alter the apatite structure, and Mg remains bonded with the phosphate groups.

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Citrate Improves Biomimetic Mineralization Induced by Polyelectrolyte–Cation Complexes Using PAsp‐Ca&Mg Complexes

Shen,

Xu,

et al. 2024

Adv Healthcare Materials

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Magnesium ions are highly enriched in early stage of biological mineralization of hard tissues. Paradoxically, hydroxyapatite (HAp) crystallization is inhibited significantly by high concentration of magnesium ions. The mechanism to regulate magnesium‐doped biomimetic mineralization of collagen fibrils has never been fully elucidated. Herein, we revealed that citrate could bio‐inspire the magnesium‐stabilized mineral precursors to generate magnesium‐doped biomimetic mineralization as follows: Citrate could enhance the electronegativity of collagen fibrils by its absorption to fibrils via hydrogen bonds. Afterward, electronegative collagen fibrils could attract highly‐concentrated electropositive polyaspartic acid‐Ca&Mg (PAsp‐Ca&Mg) complexes followed by phosphate solution via strong electrostatic attraction. In the meanwhile, citrate adsorbed in/on fibrils could eliminate mineralization inhibitory effects of magnesium ions by breaking hydration layer surrounding magnesium ions and thus reduce dehydration energy barrier for rapid fulfillment of biomimetic mineralization. The remineralized demineralized dentin with magnesium‐doped HAp possessed antibacterial ability and the mineralization mediums possessed excellent biocompatibility via cytotoxicity and oral mucosa irritation tests. This strategy should shed light on cationic ions‐doped biomimetic mineralization with antibacterial ability via modifying collagen fibrils and eliminating mineralization inhibitory effects of some cationic ions, as well as could excite attention to the neglected multiple regulations of small biomolecules, such as citrate, during biomineralization process.This article is protected by copyright. All rights reserved

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Investigation on antibacterial and hemolytic properties of magnesium-doped hydroxyapatite nanocomposite

Cited by 32 publications

References 29 publications

Nanoarchitectonics of Hydroxyapatite/Molybdenum Trioxide/Graphene Oxide Composite for Efficient Antibacterial Activity

Nanoarchitectonics of Hydroxyapatite/Molybdenum Trioxide/Graphene Oxide Composite for Efficient Antibacterial Activity

The Effects of Electron Beam Irradiation on the Morphological and Physicochemical Properties of Magnesium-Doped Hydroxyapatite/Chitosan Composite Coatings

Citrate Improves Biomimetic Mineralization Induced by Polyelectrolyte–Cation Complexes Using PAsp‐Ca&Mg Complexes

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