Investigation of wound healing effect of topical gel of Albizia amara leaves extract

Devi, D. Ramya; Lakshna, S. Sowmiya; Parvathi, S. Veena; Hari, B.N. Vedha

doi:10.1016/j.sajb.2018.10.005

Cited by 12 publications

(5 citation statements)

References 9 publications

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“…In a previous research, n-hexadecanoic acid was the main compound found in the A. amara leave extracts, and it was shown to have wound healing properties [24]. Using HPLC-PDA-ESI-MS analysis, mainly flavonoids and galloyl glucoside derivatives related to antioxidant and anti-inflammatory activities were found in the methanolic extract of A. anthelmintica leaves [19].…”

Section: Resultsmentioning

confidence: 96%

Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Phuaklee¹,

Dechayont²,

Chunthorng-Orn³

et al. 2021

ScienceAsia

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Section: Resultsmentioning

confidence: 96%

Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Phuaklee¹,

Dechayont²,

Chunthorng-Orn³

et al. 2021

ScienceAsia

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“…The viscosity of the gel formulations was determined using a Brookfield viscometer with spindle no. 64 at 50 rpm [26]. The hydrogel was lyophilized using a freeze dryer at a temperature of −55 • C and a pressure of 30 Pa for 48 h to remove any remaining solvents.…”

Section: Instrumentationsmentioning

confidence: 99%

“…The optimum viscosity of Carbopol for good spreadability is typically achieved at a pH range of 6.5-7.5 [82]. Therefore, the pH value of the formulation was adjusted to the range between 7.0-7.4, which was in the optimum range and suitable to be used on human skin [26,83]. There were no significant changes in the pH of the formulation after several weeks of studies, indicating good stability and long lifespan of the formulations [84].…”

Section: Hydrogel Formulationsmentioning

confidence: 99%

Hydrophobic Drug Carrier from Polycaprolactone-b-Poly(Ethylene Glycol) Star-Shaped Polymers Hydrogel Blend as Potential for Wound Healing Application

et al. 2023

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Blending hydrogel with an amphiphilic polymer can increase the hydrophobic drug loading and entrapment efficiency of hydrogel-based formulations. In this study, a hydrogel formulation with star-shaped polycaprolactone-b-poly(ethylene glycol) (PCL-b-PEG) as the hydrophobic drug cargo is produced. The 4-arm and 6-arm star-shaped PCL are synthesized with different molecular weights (5000, 10,000, 15,000 g/mol) via ROP and MPEG as the hydrophilic segment is attached via the Steglich esterification. FTIR and 1H-NMR analysis showed the presence of all functional groups for homopolymers and copolymers. Mn for all synthesized polymers is close to the theoretical value while GPC spectra showed a monomodal peak with narrow molecular weight distribution (PDI:1.01–1.25). The thermal degradation temperature and crystalline melting point of synthesized polymers increase with the increase in molecular weight and number of arms. All formulations possess high drug loading and entrapment efficiency (>99%) and increase with increasing molecular weight, number of arms, and amount of polymer in the formulations. All formulations showed a sustained drug release pattern with no initial burst, which follows the Korsmeyer–Peppas kinetic model. The polymer hydrogel formulations showed antibacterial activity against E. coli and S. aureus. The hydrogel containing 4-arm PCL15k-PEG is chosen as the best formulation due to its high drug release, good antimicrobial activity, and morphology.

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“…In previous studies on the phytochemical analysis of the genus Albizia, alkaloids [24], flavonoids, saponins [34], tannins [36], and terpenes [71], lignanoids and phenolic glycosides [20,35] have been reported. D. Ramya Devi et al [49] isolated glycerin, ethyl α-D-glucopyranoside and n-hexadecanoic acid from an aqueous leaf extract of Albizia amara.…”

Section: Compounds and Phytochemicals In The Genus Albiziamentioning

confidence: 99%

Secondary Metabolite Composition and Bioactivity of Genus Albizia: A Review

Sowe

2023

JSMARTech

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Traditional medicine is being revalued all around the world because of considerable research on various plant species and their therapeutic properties. Traditional medicinal beliefs and practices are deeply rooted in The Gambia, and forest resources are a source of plants for medicine. A study has estimated the presence of one hundred and fifty ( 150) plant species in The Gambia, distributed between 28 different plant families. Among the plant species, Albizia seems to possess numerous pharmacological properties. Albizia plants are high in secondary metabolites, according to phytochemical investigations, and pharmacological tests of plant extracts have demonstrated antibacterial, anti-inflammatory, and analgesic effects. Albizia plant components are used in traditional medicine to cure a variety of diseases like lung infections, asthma, pile, diarrhea, gonorrhea, ulcers, hemorrhoids, anxiety, depression, and insomnia. Different solvent extracts of the genus Albizia have demonstrated excellent efficacy against S

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Investigation of wound healing effect of topical gel of Albizia amara leaves extract

Cited by 12 publications

References 9 publications

Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Hydrophobic Drug Carrier from Polycaprolactone-b-Poly(Ethylene Glycol) Star-Shaped Polymers Hydrogel Blend as Potential for Wound Healing Application

Secondary Metabolite Composition and Bioactivity of Genus Albizia: A Review

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