Investigation of two possible modes of action of gastrone, an endogenous inhibitor of gastric secretion

Baume, Peter; Law, David

doi:10.1007/bf02233084

Cited by 7 publications

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“…These results, together with those of Baume and Law (1966), indicate that gastrone exerts its inhibitory effect at a site in the gastric secretory process proximal to the parietal cell. Present studies are under way to measure the effect of gastrone on acid secretion initiated by other stimulants.…”

Section: Discussionsupporting

confidence: 63%

“…It seemed logical to examine the effect of gastrones on gastric secretion stimulated at different points in the complex gastric secretory process in order to locate the site of the inhibition of acid secretion. Work to date has indicated that gastrone from canine gastric mucus neither interferes with the dynamic exchange of hydrogen ions between gastric mucosa and gastric juice nor diminishes gastric acid secretion stimulated by maximal effective doses of histamine (Baume and Law, 1966). These results have suggested but have not proved that canine gastric mucus does not exert its effect on the parietal cell, the end organ of gastric acid secretion.…”

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confidence: 94%

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The Effect of Two Different Gastrones on Acid Secretion by the Rat in Vivo and by Isolated Rat Gastric Mucosa

Baume

Nicholls

1966

Australasian Annals of Medicine

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A number of substances (" gastrones ") found in gastro-intestinal mucous secretions inhibit gastric acid secretion when given by intravenous injection in vivo. The mode of this action is unknown. The present experiments have defined the effect of two potent gastrones on acid secretion by isolated rat gastric mucosa. In each instance the addition of the gastronE preparation to the solution bathing the in-vitro mucosal preparation resulted in significant extra secretion of acid, although the same gastrone preparations had inhibited acid secretion in the intact animal. This paradoxical stimulant effect of gastrone on isolated gastric mucosa has not previously been described. Its demonstration is evidence that the inhibitory action of these substances in the intact animal is exerted at a more proximal site than the parietal cell.

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Section: Discussionsupporting

confidence: 63%

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confidence: 94%