Effects of nicotine and tobacco smoke on gastric secretion in rats with gastric fistulas

Thompson, John N.

doi:10.1007/bf02233450

Cited by 19 publications

(6 citation statements)

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“…Both concentration and output of HC1 was decreased in all series of rats in our acute study with NHT. Also in agreement with T hompson [19], NHT induced the decrease in acid and pepsin output in histamine-stimulated rats. Using gastrin-like pentapeptide (ICI-50123, Ayerst Lab., USA) as gastric stimulant, T hompson [19] observed that NHT inhibited only pepsin output without affecting volume and acid of gastric secretion.…”

Section: Discussionsupporting

confidence: 63%

“…Also in agreement with T hompson [19], NHT induced the decrease in acid and pepsin output in histamine-stimulated rats. Using gastrin-like pentapeptide (ICI-50123, Ayerst Lab., USA) as gastric stimulant, T hompson [19] observed that NHT inhibited only pepsin output without affecting volume and acid of gastric secretion. We used another gastrin-like substance, pentagastrin, which is a tetrapeptide (Peptavlon, Ayerst Lab., USA).…”

Section: Discussionsupporting

confidence: 63%

“…With ICI-50123 (pentapeptide)-stimulated secretion, nicotine depressed only pepsin output [19]. The concentrations of HC1 and pepsin were not discussed in these studies [19,20]. Thompson et al [21] also reported on chronic effects of nicotine on rat gastric secretion.…”

mentioning

confidence: 89%

“…With histamine-stimulated secretion, nicotine depressed, to a varying degree, the output of HC1 and pepsin, and the volume of juice. With ICI-50123 (pentapeptide)-stimulated secretion, nicotine depressed only pepsin output [19]. The concentrations of HC1 and pepsin were not discussed in these studies [19,20].…”

mentioning

confidence: 99%

“…They injected nicotine hydrogen tar trate into pylorus-ligated rats, using a 2-hour collection period, and found a significant depression in the output of HC1 and pepsin. Thompson [19] also studied the effect of nicotine and tobacco smoke on gastric secretion in rats with gastric fistula. In this study he collected gastric juice for 7 h. Drugs were injected subcutaneously.…”

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confidence: 99%

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Effect of Nicotine Hydrogen Tartrate on Gastric Secretion of Normal and Vagotomized Rats Stimulated with Histamine Pentagastrin and Bethanechol Chloride

Kowalewski¹

1974

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Effect of acute and chronic treatment with nicotine hydrogen tartrate (NHT), on gastric secretion, was assessed in intact and vagotomized rats bearing permanent gastric fistulas. Intravenous infusion of NHT for 24 h with simultaneous collection of gastric juice demonstrated the inhibitory action of this drug on basal secretion and secretion stimulated with histamine, pentagastrin, and bethanechol chloride. Inhibition affected output of HC1 and pepsin and concentration of HC1. In nonstimulated and in bethanechol-stimulated rats, NHT also decreased the concentration of pepsin. Chronic treatment of rats with NHT also induced the inhibition of gastric secretion under various stimulation conditions. Inhibitory action of NHT on gastric secretion was also observed in vagotomized rats stimulated by secretagogues used in this study.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionsupporting

confidence: 63%

mentioning

confidence: 89%

mentioning

confidence: 99%

mentioning

confidence: 99%

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