The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.
Summary
Elution of Na2Cr51O4 after binding to Ehrlich ascites tumour cells is considerable, both in vitro and in vivo. The distribution and excretion of intravenously injected free Na2Cr51O4 have been determined and with these data it has been estimated that approximately 64 per cent of isotope associated with tumour cells is lost in the first 24 hours after their intravenous injection into mice. Most (but not all) of the activity in the liver and spleen, and all of the activity in the kidneys after such an injection is due to the distribution of eluted isotope.
However, a significant excess of radioactivity in the lungs of female mice when compared with male mice within one minute of injection of labelled cells is consistent with previous reports of greater metastatic tumour growth in female mice. Evidence is presented to show that clution of isotope is not responsible for this difference.
The problem of blood replacement in the individual cancer patient remains unanswered. On present evidence, such a patient must be assumed to be drawn from a population with a mean total blood volume and mean red-cell volume below normal and thus must be assumed to have a better-than-even chance of having a depleted volume. However, it does not necessarily follow that transfusion is necessary; this should ideally be assessed by blood volume determination in each individual case.
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