Investigation of the reverse effect of Danhong injection on doxorubicin-induced cardiotoxicity in H9c2 cells: Insight by LC–MS based non-targeted metabolomic analysis

Yi, Xiaojiao; Zhu, Junfeng; Zhang, Jinghui; Gao, Yun; Chen, Zhongjian; Lu, Shihai; Cai, Zongwei; Hong, Yanjun; Wu, Yongjiang

doi:10.1016/j.jpba.2018.02.012

Cited by 28 publications

(18 citation statements)

References 22 publications

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“…A Chinese medicine Dan-Hong injection is demonstrated to alleviate ischemic myocardial injury and improve heart function. Recently, this injection is reported to restore doxorubicin-induced cardiotoxicity in H9c2 cells by improving energy metabolism and reducing oxidative stress (Yi et al, 2018 ). San-Yang-Xue-Dai mixture alleviates doxorubicin-induced cardiotoxicity and apoptosis by inhibiting p53 and MAPK signaling activation (Chen et al, 2018 ).…”

Section: Attenuation Of Cardiotoxicity Mainly By Balancing Energy Metmentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

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Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer. Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity. This review focuses in detail on the effectiveness of these natural products, and describes the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. Recent advances in the efficacy of natural dietary supplements to counteract these side effects are highlighted. In addition, we draw particular attention to gut microbiotan in the context of prebiotic potential of natural products for the protection against cancer therapy-induced toxicities. We conclude that some natural products are potential therapeutic perspective for the prevention and treatment of chemotherapy and radiotherapy-induced side effects. Further studies are required to validate the efficacy of natural products in cancer patients, and elucidate potential underlying mechanisms.

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Section: Attenuation Of Cardiotoxicity Mainly By Balancing Energy Metmentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

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“…LC-MS analysis was conducted as previously described (26). The Ultimate 3000 UHPLC system (Dionex, Idstein, Germany), linked to a Q Exactive orbitrap mass Spectrometer (Thermo Fisher Scientific, Bremen, Germany), was used.…”

Section: Lc-ms Analysismentioning

confidence: 99%

Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma

et al. 2020

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Background: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy with a poor prognosis. Although studies have shown metabolic reprogramming to be linked to ESCC development, no prognostic metabolic biomarkers or potential therapeutic metabolic targets have been identified. Method: The present study investigated some circulating metabolites associated with overall survival in 276 curatively resected ESCC patients using liquid chromatography/mass spectrometry metabolomics and Kaplan-Meier analysis. Tissue metabolomic analysis of 23-paired ESCC tissue samples was performed to discover metabolic dysregulation in ESCC cancerous tissue. A method consisting of support vector machine recursive feature elimination and LIMMA differential expression analysis was utilized to select promising feature genes within transcriptomic data from 179-paired ESCC tissue samples. Joint pathway analysis with genes and metabolites identified relevant metabolic pathways and targets for ESCC. Results: Four metabolites, kynurenine, 1-myristoyl-glycero-3-phosphocholine (LPC(14:0)sn-1), 2-piperidinone, and hippuric acid, were identified as prognostic factors in the preoperative plasma from ESCC patients. A risk score consisting of kynurenine and LPC(14:0)sn-1 significantly improved the prognostic performance of the tumor-node-metastasis staging system and was able to stratify risk for ESCC. Combined tissue metabolomic analysis and support vector machine recursive feature elimination gene selection revealed dysregulated kynurenine pathway as an important metabolic feature of ESCC, including accumulation of tryptophan, formylkynurenine, and kynurenine, as well as up-regulated indoleamine 2,3-dioxygenase 1 in ESCC cancerous tissue. Chen et al. Metabolic Features of ESCC Conclusions: This work identified for the first time four potential prognostic circulating metabolites. In addition, kynurenine pathway metabolism was shown to be up-regulated tryptophan-kynurenine metabolism in ESCC. Results not only provide a metabolite-based risk score system for prognosis, but also improve the understanding of the molecular basis of ESCC onset and progression, and as well as novel potential therapeutic targets for ESCC.

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“…The above effects of DHI may be through inhibition of the β-adrenergic pathway and protein kinase Cε (PKCε) [106]. At the cellular level, DHI reverses doxorubicin (DOX)-induced cardiac toxicity in H9C2 cells by improving energy metabolism and reducing oxidative stress [107]. DHI has a protective effect against hypoxia/reoxygenation and H2O2-induced cardiomyocyte injury, which may be mediated through the alleviation of Ca 2+ overload and ROS content, thereby suppressing the opening of the mitochondrial permeability transition pore (mPTP) [108].…”

Section: Experimental Studies and Molecular Mechanismsmentioning

confidence: 99%

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential

Feng

Wang

et al. 2019

Pharmacological Research

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Cardiovascular and cerebrovascular diseases are the main cause of mortality worldwide, currently with less than optimum therapeutic options. Danhong injection (DHI) is a medicinal preparation based on two eminent Chinese herbal medicines, Salviae Miltiorrhizae (Dan Shen; family: Lamiaceae) and Flos Carthami (Hong Hua; family: Compositae/Asteraceae). DHI has been mainly used in the clinical therapy of cardiovascular (such as acute coronary syndrome and angina pectoris) and cerebrovascular diseases (such as stroke) in China for many years. The pharmacological properties of DHI include anti-inflammatory, anti-oxidant, anti-coagulatory, hypolipidemic, anti-apoptotic, vasodilatory, and angiogenesis-promoting actions. DHI offers a safe and effective therapeutic agent against cardiovascular and cerebrovascular diseases by modulating multiple disease-relevant signaling pathways and molecular targets. Herein, we provide a comprehensive review of the phytochemistry, therapeutic effects, molecular mechanisms, and adverse reactions of DHI in cardiovascular and cerebrovascular diseases. We also highlight the latest pharmacological advances and therapeutic potential of this promising herb-derived cardiovascular drug preparation.

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Investigation of the reverse effect of Danhong injection on doxorubicin-induced cardiotoxicity in H9c2 cells: Insight by LC–MS based non-targeted metabolomic analysis

Cited by 28 publications

References 22 publications

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential

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