The present study was conducted to determine the content of Stilbenes in the several autochthonous West Georgian grapes and wines. Stilbenes were analyzed using HPLC-UV samples and were prepared using resin (amberlite XAD2) column, C18 Cartridge Solid Phase Extraction (SPE) Waters Sep-Pak C18 (500 mg). The identification was achieved using UPLC-PDA and MS analysis. The study was conducted on the following Stilbenes and their derivatives -Astringin, Piceid, Trans/cis resveratrol, and ε-Viniferin. The amount of stilbenes in grapes was determined as: Aladasturi-131.9±4.8 mg kg-1, Aleksandrouli 148.2±4.9 mg kg-1, Mujuretuli 215.3±7.9 mg kg-1 , Chkhaveri 77.5 ±2.5 mg kg-1, Ojaleshi 260.71±9.1mg kg-1 . In red wines the content of Stilbenes was Aladasturi-19.17±0.5 mg kg-1, Aleksandrouli 14. 87±0.4 mg kg-1, Mujuretuli 21.36±0.5 mg kg-1, Chkhaveri 14.5±0.4 mg kg-1, Ojaleshi 60.8±2.2 mg kg-1.