Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”

Ozalp, Yildiz; Chunu, Joseph T.; Jiwa, Nailla

doi:10.4274/tjps.galenos.2019.38278

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…All drugs were selected, having various flowability and compressibility. Paracetamol and mefenamic acid are poorly soluble, poorly compressible, brittle with poor flow property [10][11][12] and required in high dose. 13 Mefenamic acid has higher sticking tendency.…”

Section: Dilution Potentialmentioning

confidence: 99%

Comparative Study of Isomalt and Co-processed Isomalt

S B,

M P

2023

IJDDT

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Objective: The study aims to compare the tableting qualities of isomalt and co-processed isomalt. Methodology: Co-processed isomalt prepared by melt granulation method evaluated for flow property, dilution potential, Kawakita plot, consolidation index, tabletability, Heckel plot and elastic recovery and compared with isomalt. Result and Discussion: The co-processed isomalt demonstrated superior packing ability compared to isomalt and got rearranged in the early compression stage, as per modified Kawakita equation. Co-processed isomalt had 40% dilution potential for paracetamol as compared with 20% for isomalt. Co-processed isomalt showed 40% dilution potential for ascorbic acid, and nimesulide, whereas mefenamic acid and aspirin showed 30% dilution potential. Co-processed isomalt overcomes the lamination and sticking problem of isomalt which has better tabletability.

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Section: Dilution Potentialmentioning

confidence: 99%

Comparative Study of Isomalt and Co-processed Isomalt

S B,

M P

2023

IJDDT

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“…The obtained diagram can be evaluated as an in-die porosity if the graph is evaluated from the calculation of the volume of the powder during one compression cycle, or out-die porosity if the porosity is determined from the volume of the resulting tablets with the use of different compression pressures (Figure 8). Pressure-porosity functions have been used for material characterization, i.e., their compressibility (22)(23)(24) or determination of the mechanism of the material deformation (elastic vs plastic or fragmentation (25)). The importance of establishing the relation of three powder characteristics: compressibility, compactibility and tabletability, has been highlighted by the Amidon (26).…”

Section: Pressure-porosity Functionsmentioning

confidence: 99%

Usage of compaction simulators for the powder compression characterization: Advantages and limitations

Nikolić¹,

Miletic²,

Kovačević³

et al. 2022

Arhiv za farmaciju

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Compaction simulators are designed as machines which can provide an in-depth analysis of the powder compaction process. Characterization of the powder compression and compaction process, as well as material characterization, play an important role in the formulation and manufacturing process design and development, as well as in creating a strong knowledge basis for the scale-up of the tablet compression and troubleshooting in further stages of the product lifecycle. Although compaction simulators are designed to simulate the compression process on high-speed tablet-presses, with the advantages of a small quantity of material needed and highly sophisticated instrumentation, there are certain limitations in the extrapolation of the process parameters from these machines to high-speed rotary tablet presses. However, the advantage of the use of compaction simulators for studying basic compression and compaction mechanisms, identification of critical material attributes and critical process parameters ranges, and their relations with tablet characteristics and critical quality attributes of pharmaceutical products is clear, compared to the use of small excentre tablet presses, and complementary to the use of small rotary tablet presses. This scientific paper provides an overview and examples of the different advantages provided by the instrumentation of compaction simulators, including certain limitations in their exploitation.

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“…All drugs were selected, having various flowability and compressibility. Paracetamol and mefenamic acid are poorly soluble, poorly compressible, brittle with poor flow property [23][24][25] and required in high dose. 26 Mefenamic acid has higher sticking tendency.…”

Section: Dilution Potentialmentioning

confidence: 99%

Development of Novel Directly Compressible Isomalt-based Co-processed Excipient

S B,

M P,

Nazma

2022

IJDDT

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Objective: The study aims to improve the tableting qualities by coprocessing isomalt with PEG 4000 and crospovidone. Methodology: The melt granulation method was adopted for coprocessing isomalt with PEG 4000 and crospovidone. The proportion of constituents was optimized using full factorial design. Particle size distribution, true density, moisture content, flowability, flow rate, SEM analysis, dilution potential, and tablet ability were all examined for optimized co-processed isomalt-based excipient and compared with isomalt. Result and Discussion: Co-processed isomalt-based excipients had 40% dilution potential for paracetamol as compared with 20% for isomalt. Co-processed isomalt-based excipient showed 30% dilution potential for mefenamic acid and aspirin. Co-processed isomalt overcomes the lamination and sticking problem, which has better tablet ability, binding, disintegration, and lubricating potential.

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Investigation of the Compressibility Characteristics of Paracetamol using “Compaction Simulator”

Cited by 4 publications

References 25 publications

Comparative Study of Isomalt and Co-processed Isomalt

Comparative Study of Isomalt and Co-processed Isomalt

Usage of compaction simulators for the powder compression characterization: Advantages and limitations

Development of Novel Directly Compressible Isomalt-based Co-processed Excipient

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