Comparative Study of Isomalt and Co-processed Isomalt

Abstract

Objective: The study aims to compare the tableting qualities of isomalt and co-processed isomalt. Methodology: Co-processed isomalt prepared by melt granulation method evaluated for flow property, dilution potential, Kawakita plot, consolidation index, tabletability, Heckel plot and elastic recovery and compared with isomalt. Result and Discussion: The co-processed isomalt demonstrated superior packing ability compared to isomalt and got rearranged in the early compression stage, as per modified Kawakita equation. Co-processed isomalt had 40% dilution potential for paracetamol as compared with 20% for isomalt. Co-processed isomalt showed 40% dilution potential for ascorbic acid, and nimesulide, whereas mefenamic acid and aspirin showed 30% dilution potential. Co-processed isomalt overcomes the lamination and sticking problem of isomalt which has better tabletability.