Development of Novel Directly Compressible Isomalt-based Co-processed Excipient

Abstract

Objective: The study aims to improve the tableting qualities by coprocessing isomalt with PEG 4000 and crospovidone. Methodology: The melt granulation method was adopted for coprocessing isomalt with PEG 4000 and crospovidone. The proportion of constituents was optimized using full factorial design. Particle size distribution, true density, moisture content, flowability, flow rate, SEM analysis, dilution potential, and tablet ability were all examined for optimized co-processed isomalt-based excipient and compared with isomalt. Result and Discussion: Co-processed isomalt-based excipients had 40% dilution potential for paracetamol as compared with 20% for isomalt. Co-processed isomalt-based excipient showed 30% dilution potential for mefenamic acid and aspirin. Co-processed isomalt overcomes the lamination and sticking problem, which has better tablet ability, binding, disintegration, and lubricating potential.