Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding

Shefa, Anha Afrin; Taz, Mirana; Hossain, Monir; Kim, Yong Sik; Lee, Sun Young; Lee, Byong‐Taek

doi:10.1016/j.ijbiomac.2018.12.079

Cited by 46 publications

(21 citation statements)

References 61 publications

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“…Thus, DMSO treatment before TEMPO-oxidation could affect the distribution and dimension of the obtained CNF. This study also shows that FNB can be considered as a source of CNF that can be used in various biomedical applications [43].…”

Section: Morphological Analysismentioning

confidence: 59%

Novel Pretreatment Performance Evaluation for Cellulose Nanofibrils Extraction from Ficus natalensis Barkcloth

Alasood

Farooq

et al. 2021

J Polym Environ

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Recently, nanosized cellulose materials extraction is extensively interesting from the sources of sustainable materials. Cellulose nano brils (CNF) extraction through green bio-based materials featured as promising interest in the eld of science. In this study, dimethyl sulfoxide (DMSO) was applied to examine its effectiveness in pretreating the Ficus natalensis barkcloth cellulose (FNBC) for CNF production perior to 2,2,6,6,-tetramethylpiperidine-1-oxyl (TEMPO) oxidation. The pretreatment performance of DMSO was evaluated based on the structural and morphological changes. DMSO pretreated FNBC attained the most dramatic morphological changes as compared to untreated cellulose samples. The results of scanning electron microscope (SEM) and transmission electron microscope (TEM) shows that there is an extentive structural disruption of FNBC during the pretreatment process, could be because of outstanding ability to eliminate non-cellulosic materials and amorphous regions from the FNBC, con rmed by the X-ray diffractometry (XRD) showing higher crystallinity values as well as higher thermal stablilites values of pretreated FNBC samples were also noted. Overall, this study revealed tremendously effective and pioneer pretreatment method for fractionating FNBC, to stimulate the successive extraction of cellulose nano brils. Furthermore, on the basis of the cellulose and CNF characterizations, this study showed that Ficus natalensis barkcloth could be considered as an alternative source of cellulose for potential value-added industrial applications such as food industry, paper making, and biomedicines.

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Section: Morphological Analysismentioning

confidence: 59%

Novel Pretreatment Performance Evaluation for Cellulose Nanofibrils Extraction from Ficus natalensis Barkcloth

Alasood

Farooq

et al. 2021

J Polym Environ

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“…A previous study reported that ZnO nanoparticles can induce the aggregation of RBC without disrupting its membranes. [ 28 ] These results proved that the hydrophilic property and the presence of ZnO can facilitate the firm adhesion of blood components onto the bioactive P‐20/PEG/ZnO mats and can be used as potential trauma dressings.…”

Section: Resultsmentioning

confidence: 87%

Bioactive Poly(4‐hydroxybutyrate)/Poly(ethylene glycol) Fibrous Dressings Incorporated with Zinc Oxide Nanoparticles for Efficient Antibacterial Therapy and Rapid Clotting

Yuan

Sun

Shen

et al. 2022

Macromolecular Bioscience

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Antibacterial and hemostatic properties are of great importance to wound dressing in treating trauma. Poly(4-hydroxybutyrate) (P4HB), an U.S. Food and Drug Administration (FDA)-approved bioabsorbable polyester, is used as dermal substitutes to prevent sever wound contraction and improve wound healing. However, P4HB fibrous mats are not efficient in halting bleeding and preventing bacterial associated infection. Here the authors prepare a new kind of wound dressing by incorporating poly(ethylene glycol) (PEG) and zinc oxide (ZnO) nanoparticles into the P4HB matrix by using electrospinning method. The in vitro results reveal that the P4HB/PEG/ZnO dressings can synergistically help blood clotting, prevent bacteria adhesion, and kill bacteria efficiently. It's found that the bactericidal activity of the bioactive P4HB/PEG/ZnO dressings is related to the release of Zn 2+ ions rather than reactive oxygen species (ROS) under dark condition. The in vivo antibacterial evaluation indicates that the bioactive P4HB/PEG/ZnO dressings can successfully prevent wound infections in Sprague-Dawley (SD) rats' skin defect model. The in vivo hemostatic experiments evaluated in the rabbit ear injury model further confirm that the bioactive P4HB/PEG/ZnO dressings have excellent hemostatic performance. Hence, this study demonstrates that the bioactive P4HB/PEG/ZnO dressings with hemostatic and bactericidal properties have great potential in possible clinical applications.

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“…The obtained results displayed a reduced bleeding time in the case of the 5% PEG scaffold as compared to the 10% PEG one. In another study [ 82 ], an electrospun nanofibrous hybrid wound-dressing from PCL/collagen for sustained delivery of insulin into the wound bed was obtained. Insulin plays a crucial part in glucose uptake by skin cells and can stimulate keratinocytes and fibroblasts proliferation and migration.…”

Section: Engineered Scaffolds For Wound Healingmentioning

confidence: 99%

Scaffolds for Wound Healing Applications

2020

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In order to overcome the shortcomings related to unspecific and partially efficient conventional wound dressings, impressive efforts are oriented in the development and evaluation of new and effective platforms for wound healing applications. In situ formed wound dressings provide several advantages, including proper adaptability for wound bed microstructure and architecture, facile application, patient compliance and enhanced therapeutic effects. Natural or synthetic, composite or hybrid biomaterials represent suitable candidates for accelerated wound healing, by providing proper air and water vapor permeability, structure for macro- and microcirculation, support for cellular migration and proliferation, protection against microbial invasion and external contamination. Besides being the most promising choice for wound care applications, polymeric biomaterials (either from natural or synthetic sources) may exhibit intrinsic wound healing properties. Several nanotechnology-derived biomaterials proved great potential for wound healing applications, including micro- and nanoparticulate systems, fibrous scaffolds, and hydrogels. The present paper comprises the most recent data on modern and performant strategies for effective wound healing.

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Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding

Cited by 46 publications

References 61 publications

Novel Pretreatment Performance Evaluation for Cellulose Nanofibrils Extraction from Ficus natalensis Barkcloth

Novel Pretreatment Performance Evaluation for Cellulose Nanofibrils Extraction from Ficus natalensis Barkcloth

Bioactive Poly(4‐hydroxybutyrate)/Poly(ethylene glycol) Fibrous Dressings Incorporated with Zinc Oxide Nanoparticles for Efficient Antibacterial Therapy and Rapid Clotting

Scaffolds for Wound Healing Applications

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