Investigation into the erosion mechanism of salicylate‐based poly(anhydride‐esters)

Whitaker-Brothers, Kenya; Uhrich, Kathryn E.

doi:10.1002/jbm.a.30356

Cited by 49 publications

(63 citation statements)

References 23 publications

(13 reference statements)

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“…All salicylate -based polymers degrade to produce salicylic acid and all of these were found to follow primarily surface erosion patterns [52] . Furthermore, effect of media on degradation rate was studied and found to increase marginally better (14%) in media containing actively growing bacterial culture than sterile media.…”

Section: Salicylate -Based Polyanhydridesmentioning

confidence: 99%

Polyanhydrides

Domb¹,

Jain²,

Kumar³

2011

Handbook of Biodegradable Polymers

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Section: Salicylate -Based Polyanhydridesmentioning

confidence: 99%

Polyanhydrides

Domb¹,

Jain²,

Kumar³

2011

Handbook of Biodegradable Polymers

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“…SA has been incorporated into poly(anhydride-esters), 16,17 dendrimers, 18 biopolymers, 19 micelles, 20 polyurethanes 21 etc. for use as an anti-inflammatory, anti-oxidative, antibacterial and/or antibiofilm formation agent.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters

2015

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The purpose of this work was to develop a family of cross-linked poly(xylitol adipate salicylate)s with a wide range of tunable release properties for delivering pharmacologically active salicylic acid. The synthesis parameters and release conditions were varied to modulate polyester properties and to understand the mechanism of release. Varying release rates were obtained upon longer curing (35% in the noncured polymer to 10% in the cured polymer in 7 days). Differential salicylic acid loading led to the synthesis of polymers with variable cross-linking and the release could be tuned (100% release for the lowest loading to 30% in the highest loading). Controlled release was monitored by changing various factors, and the release profiles were dependent on the stoichiometric composition, pH, curing time, and presence of enzyme. The polymer released a combination of salicylic acid and disalicylic acid, and the released products were found to be nontoxic. Minimal hemolysis and platelet activation indicated good blood compatibility. These polymers qualify as "bioactive" and "resorbable" and can, therefore, find applications as immunomodulatory resorbable biomaterials with tunable release properties.

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“…26, 27 PAEs developed by the Uhrich group predominantly undergo surface erosion, which permits well-controlled polymer degradation with near zero-order bioactive release kinetics. 28 …”

Section: Introductionmentioning

confidence: 99%

Polyactives: controlled and sustained bioactive release via hydrolytic degradation

Stebbins

Faig

et al. 2015

Biomater. Sci.

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Significant and promising advances have been made in the polymer field for controlled and sustained bioactive delivery. Traditionally, small molecule bioactives have been physically incorporated into biodegradable polymers; however, chemical incorporation allows for higher drug loading, more controlled release, and enhanced processability. Moreover, the advent of bioactive-containing monomer polymerization and hydrolytic biodegradability allows for tunable bioactive loading without yielding a polymer residue. In this review, we highlight the chemical incorporation of different bioactive classes into novel biodegradable and biocompatible polymers. The polymer design, synthesis, and formulation are summarized in addition to the evaluation of bioactivity retention upon release via in vitro and in vivo studies.

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Investigation into the erosion mechanism of salicylate‐based poly(anhydride‐esters)

Cited by 49 publications

References 23 publications

Polyanhydrides

Polyanhydrides

Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters

Polyactives: controlled and sustained bioactive release via hydrolytic degradation

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