Polyanhydrides

Domb, Abraham J.; Jain, Jay Prakash; Kumar, Neeraj

doi:10.1002/9783527635818.ch3

Cited by 19 publications

(22 citation statements)

References 175 publications

(154 reference statements)

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“…The size, geometry, and composition of the metallic nanostructures within the device should be assessed systematically to identify those that most efficiently convert light into heat; additionally, the distribution of nanomaterials throughout the membrane might be designed to maximize heat transfer between the gold and NG. Finally, fully bioresorbable devices might be achieved by replacing the ethylcellulose components with biodegradable materials (39,40), although the degradation kinetics would need to be sufficiently slow to avoid uncontrolled release of remaining drug.…”

Section: Discussionmentioning

confidence: 99%

Near-infrared–actuated devices for remotely controlled drug delivery

Timko

Arruebo

Shankarappa

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

182

175

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A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage to desired effect, with a consequent minimization of toxicity, and could obviate repeated drug administrations or device implantations, enhancing patient compliance. It should exhibit low off-state leakage to minimize basal effects, and tunable on-state release profiles that could be adjusted from pulsatile to sustained in real time. Despite the clear clinical need for a device that meets these criteria, none has been reported to date to our knowledge. To address this deficiency, we developed an implantable reservoir capped by a nanocomposite membrane whose permeability was modulated by irradiation with a near-infrared laser. Irradiated devices could exhibit sustained onstate drug release for at least 3 h, and could reproducibly deliver short pulses over at least 10 cycles, with an on/off ratio of 30. Devices containing aspart, a fast-acting insulin analog, could achieve glycemic control after s.c. implantation in diabetic rats, with reproducible dosing controlled by the intensity and timing of irradiation over a 2-wk period. These devices can be loaded with a wide range of drug types, and therefore represent a platform technology that might be used to address a wide variety of clinical indications.gold | nanoshell | poly(n-isopropylacrylamide) | ethylcellulose | diabetes

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Section: Discussionmentioning

confidence: 99%

Near-infrared–actuated devices for remotely controlled drug delivery

Timko

Arruebo

Shankarappa

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

182

175

View full text Add to dashboard Cite

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“…[1-3] Polyanhydrides as matrices for delivering admixed drugs has been widely studied because polyanhydrides typically exhibit surface erosion, thereby resulting in more stable drug release than other classes of polymers, such as polyesters, which typically exhibit bulk degradation. [1, 4]…”

Section: Introductionmentioning

confidence: 99%

“…[1-3] Although p CPP fully degrades over three years, it is insoluble in common organic solvents and has high glass transition (T g ) and melting (T m ) temperatures, leading to difficulty in device fabrication. [1, 3] Although SA has greater solvent solubility and a lower T g and T m , it degrades completely in a matter of days. [5]…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation of an aromatic polyanhydride with enhanced thermal properties

Snyder

Anastasiou

Uhrich

2015

Polymer Degradation and Stability

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Polyanhydrides have been studied as a drug delivery vehicles due to their surface-eroding behavior which results in zero-order release. However, many polyanhyrides have thermal and solubility properties that make them difficult to formulate for these applications. Poly[α,α′-bis(ortho-carboxyphenoxy)-para-xylene] (oCPX) is an aromatic polyanhydride that has thermal and solubility properties enabling facile processing. The polymer's in vitro degradation profile exhibited an induction period up to 10 days in which degradation product concentration in the media was minimal, followed by a period of stable release of the biocompatible degradation product. Scanning electron microscope images and molecular weight changes of the polymer matrices confirm that this polymer is primarily surface-eroding. The combination of thermal properties, solubility, polymer degradation time, and erosion mechanism indicate that poly(oCPX) is be a suitable matrix candidate for extended, controlled drug delivery.

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“…5,6,7,8 Because most head and neck cancers and their cervical metastatic nodes are clinically accessible, local treatment with a polymer matrix may have significant clinical applications.…”

Section: Introductionmentioning

confidence: 99%

A Cytokine‐Delivering Polymer Is Effective in Reducing Tumor Burden in a Head and Neck Squamous Cell Carcinoma Murine Model

Lin

Luo

Zhu

et al. 2014

Otolaryngol.--head neck surg.

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Objective To evaluate the therapeutic efficacy of a novel polymer platform delivering cisplatin and cytokines in the treatment of HNSCC. Study Design in vivo study. Setting Academic research laboratory. Subjects and Methods Mice were randomized to receive implantation of (1) no polymer; (2) plain polymer; (3) plain polymer with local cisplatin injection; (4) cisplatin polymer. The two groups of mice implanted with cisplatin polymer or no polymer were further randomized to receive (1) 4 Grays external beam radiation for 4 days; (2) no radiation. For cytokine studies mice were grouped into: (1) no polymer; (2) plain polymer; (3) plain polymer with intratumoral injection of recombinant CCL21 twice a week; (4) polymer containing parental dendritic cells; (5) polymer containing dendritic cells secreting CCL21 (DC-CCL21). Results The cisplatin secreting polymer effectively reduced tumors in the mice by over 16-fold (P < 0.01). We also observed a statistically significant lower tumor weight among mice treated with cisplatin polymer and concomitant radiation compared to control groups. The DC-CCL21 polymer reduced SCCVII/SF tumors in the C3H/HeJ mice by over 41% (p<0.01). Conclusion Herein, we demonstrate the efficacy of a novel polymer platform in delivering cisplatin and cytokines. We also demonstrate that we can effectively grow dendritic cells in the polymer that can actively secrete CCL21 for a minimum of five days. This polymer may represent a new therapeutic modality for patients with HNSCC. Once this polymer platform is optimized we will plan to pursue prospective trials in patients with HNSCC.

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Polyanhydrides

Cited by 19 publications

References 175 publications

Near-infrared–actuated devices for remotely controlled drug delivery

Near-infrared–actuated devices for remotely controlled drug delivery

In vitro degradation of an aromatic polyanhydride with enhanced thermal properties

A Cytokine‐Delivering Polymer Is Effective in Reducing Tumor Burden in a Head and Neck Squamous Cell Carcinoma Murine Model

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