Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters

Abstract

The purpose of this work was to develop a family of cross-linked poly(xylitol adipate salicylate)s with a wide range of tunable release properties for delivering pharmacologically active salicylic acid. The synthesis parameters and release conditions were varied to modulate polyester properties and to understand the mechanism of release. Varying release rates were obtained upon longer curing (35% in the noncured polymer to 10% in the cured polymer in 7 days). Differential salicylic acid loading led to the synthesis of polymers with variable cross-linking and the release could be tuned (100% release for the lowest loading to 30% in the highest loading). Controlled release was monitored by changing various factors, and the release profiles were dependent on the stoichiometric composition, pH, curing time, and presence of enzyme. The polymer released a combination of salicylic acid and disalicylic acid, and the released products were found to be nontoxic. Minimal hemolysis and platelet activation indicated good blood compatibility. These polymers qualify as "bioactive" and "resorbable" and can, therefore, find applications as immunomodulatory resorbable biomaterials with tunable release properties.

Radiation Grafting of a Polymeric Prodrug onto Silicone Rubber for Potential Medical/Surgical Procedures

“…Good cell viability (>90%) was demonstrated in low-graft films (7.1%) after 24 h of incubation time for both cell lines ( Figure 5). In high-graft films (12.1% and 31.1%), we observed a significant (p < 0.05) reduction in the cell viability in both cell lines due to the high salicylic acid concentration released into the cell medium (47.5 mg/mL), as previously reported by Dasgupta et al [26,38,39]. These results support future animal studies where factors such as physiological fluids, pH, blood perfusion rate, and volume must be taken into consideration for cytocompatibility [40].…”

Neurogenesis-on-Chip: Electric field modulated transdifferentiation of human mesenchymal stem cell and mouse muscle precursor cell coculture

“…The WST-1 assay was chosen for evaluating cell viability. This specific biochemical assay was performed using water-soluble tetrazolium salts (WST-1, 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene-disulfonate, Roche) [30]. The WST-1 assay was performed after the prescribed culture durations of 3 days, 5 days and 9 days.…”

Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies

“…Apart from acne, SA has also been proven to be effective toward other types of skin conditions like psoriasis [8,9]. Different carrier materials have been used for both topological and systemic administration of SA, for example, it has been loaded into the polymer backbone in biodegradable polymers (e.g., cross-linked polyester based on xylitol and adipic acid) for a sustained release of SA [10]. SA has also been loaded into different porous matrices, in MCM-41 and SBA-15 [11] and also in halloysite nanotubes functionalized with dendrimers [12].…”