Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin)

Korogiannaki, Myrto; Samsom, Michael; Matheson, Austyn; Soliman, Karim; Schmidt, Tannin A.; Sheardown, Heather

doi:10.1021/acs.langmuir.0c02796

Cited by 16 publications

(12 citation statements)

References 49 publications

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“…The system and experimental protocol implemented here were the same as in previously reported studies investigating the lubrication properties of LUB coatings on a human cornea–PDMS interface . The PDMS–contact lens interface was exposed to a load of ∼10 kPa for each measurement, well within the range of typical loading stresses experienced at the natural eyelid–cornea biointerface. − , The experiments began with an initial friction measurement in the PBS solution, a second friction measurement after the addition of either the 2D-NSCs or LUB solutions, and a third measurement after removing the lubricants and replenishing the solution with PBS. The same surfaces were used throughout each experiment (only the liquid was changed) to minimize variations between measurements, enabling the observation of the effect on the friction coefficient values arising from the fluid exchange.…”

Section: Resultsmentioning

confidence: 87%

Novel Boundary Lubrication Mechanisms from Molecular Pillows of Lubricin Brush-Coated Graphene Oxide Nanosheets

et al. 2022

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There are numerous biomedical applications where the interfacial shearing of surfaces can cause wear and friction, which can lead to a variety of medical complications such as inflammation, irritation, and even bacterial infection. We introduce a novel nanomaterial additive comprised of two-dimensional graphene oxide nanosheets (2D-NSCs) coated with lubricin (LUB) to reduce the amount of tribological stress in biomedical settings, particularly at low shear rates where boundary lubrication dominates. LUB is a glycoprotein found in the articular joints of mammals and has recently been discovered as an ocular surface boundary lubricant. The ability of LUB to self-assemble into a "telechelic" brush layer on a variety of surfaces was exploited here to coat the top and bottom surfaces of the ultrathin 2D-NSCs in solution, effectively creating a biopolymer-coated nanosheet. A reduction in friction of almost an order of magnitude was measured at a bioinspired interface. This reduction was maintained after repeated washing (5×), suggesting that the large aspect ratio of the 2D-NSCs facilitates effective lubrication even at diluted concentrations. Importantly, and unlike LUBonly treatment, the lubrication effect can be eliminated over 15 rinsing cycles, suggesting that the LUB-coated 2D-NSCs do not exhibit any binding interactions with the shearing surfaces. The effective lubricating properties of the 2D-NSCs combined with full reversibility through rinsing make the LUB-coated 2D-NSCs an intriguing candidate as a lubricant for biomedical applications.

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Section: Resultsmentioning

confidence: 87%

Novel Boundary Lubrication Mechanisms from Molecular Pillows of Lubricin Brush-Coated Graphene Oxide Nanosheets

et al. 2022

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“…This result is similar to the tribo‐tests for articular cartilage and corneal tissue, indicating a good lubricity and wear resistance of MUC solution. [ 38,39 ]…”

Section: Resultsmentioning

confidence: 99%

Study on the Friction and Wear Properties of PEEK against Cortical Bone Tissue Under Different Lubricating Conditions

Zhang

Lin

et al. 2023

Macromolecular Bioscience

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The tribological behavior between orthopedic implants and cortical bone is important but usually neglected. Poly(ether‐ether‐ketone) (PEEK) is a promising material for orthopedic applications. To further understand and improve the interfacial tribological properties between PEEK implant and host bone tissue, a PEEK‐cortical bone tribo‐pair is designed and fabricated. The frictional and wear performance of such tribo‐pair is investigated under different lubricants, i.e., simulated body fluid (SBF), calf serum (CS), hyaluronic acid (HA), and mucin (MUC). The results suggest that MUC solution can be utilized as an artificial natural synovial fluid to improve the tribological properties of PEEK‐based implants.

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“…Additionally, they are natural boundary lubricants in vivo. The covalent addition of HA to hydrogel contact lenses can improve the wettability, reduce protein deposition, and reduce friction [ 95 , 96 ]. HA is a common anti-xerophthalmic drug used in ophthalmology.…”

Section: Hydrogel Contact Lenses For Dry Eye Treatmentmentioning

confidence: 99%

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Cao

Wang

2022

Gels

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Dry eye disease (DED) is the most common clinical ocular surface disease. Given its multifactorial etiology, no consensus has been reached on the diagnosis criteria for dry eye disease. Topical drug administration remains the mainstay of treatment but is limited to the rapid clearance from the eye surface. To address these problems, hydrogel-based materials were designed to detect biomarkers or act as drug delivery systems by taking advantage of their good biocompatibility, excellent physical and mechanical properties, and long-term implant stability. Biosensors prepared using biocompatible hydrogels can be sensitive in diagnosing DED, and the designed hydrogels can also improve the drug bioavailability and retention time for more effective and long-term treatment. This review summarizes recent advances in the use of hydrogels for diagnosing and treating dry eye, aiming to provide a novel reference for the eventual clinical translation of hydrogels in the context of dry eye disease.

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Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin)

Cited by 16 publications

References 49 publications

Novel Boundary Lubrication Mechanisms from Molecular Pillows of Lubricin Brush-Coated Graphene Oxide Nanosheets

Novel Boundary Lubrication Mechanisms from Molecular Pillows of Lubricin Brush-Coated Graphene Oxide Nanosheets

Study on the Friction and Wear Properties of PEEK against Cortical Bone Tissue Under Different Lubricating Conditions

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

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