Investigating the oxyresveratrol β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin complexes: The effects on oxyresveratrol solution, stability, and antibrowning ability on fresh grape juice

He, Jianfei; Guo, Fengxian; Li, Lin; Chen, Hongbin; Chen, Jie; Cheng, Yongqiang; Zheng, Zong‐Ping

doi:10.1016/j.lwt.2018.10.067

Cited by 28 publications

(33 citation statements)

References 26 publications

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“…In γ-CD•RSV-juices, it was reduced to half of the initial value between t14-t21 (from 43.1% to 19.8%), which may suggest some disintegration/degradation of the complex in this period of time. This result was less promising than that reported by He et al [25] for Oxy-β-CD and Oxy-HP-β-CD. Their report showed that complexes remained relatively stable in aqueous media and at 25 • C in the dark, holding more than 60% of oxyresveratrol after 30 days.…”

Section: Rsv Integrated In Juice Matrixcontrasting

confidence: 82%

“…The hosts β-CD and HP-β-CD are also reported to include oxyresveratrol, an oxidized derivative of RSV, forming inclusion complexes that are suitable delivery systems for food applications. The HP-β-CD inclusion complex with oxyresveratrol brings strong antibrowning effects on fresh grape juice [ 25 ], while milk and orange juices models fortified with β-CD·oxyresveratrol were reported to remain stable over five weeks [ 26 ]. Moreover, the complex features increased dissolution rate for resveratrol, as well as improved antioxidant activity and amounts of bioaccessible oxyresveratrol in in vitro digestion assays.…”

Section: Introductionmentioning

confidence: 99%

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Inclusion Complex of Resveratrol with γ-Cyclodextrin as a Functional Ingredient for Lemon Juices

Silva

Monteiro

Resende

et al. 2020

Foods

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Microencapsulated resveratrol (RSV) is a pertinent ingredient in functional foods to be used in the prevention and management of cardiovascular diseases. Gamma-cyclodextrin (γ-CD) was evaluated for its RSV inclusion ability. Inclusion procedures comprised mixing equal concentration of an aqueous solution of γ-CD with an ethanol solution of RSV and freeze-drying to obtain a solid material. Solid-state characterization by vibrational spectroscopy, thermogravimetry, and powder X-ray diffraction (PXRD) confirmed the formation of the γ-CD·RSV complex in a ratio of 1:1. PXRD suggested that cyclodextrin molecules in the complex are stacked in infinite channels holding the RSV inside, with a wide inter-channel space where 14 water molecules are retained. Fresh lemon juices supplemented with 0.625 mg/mL of RSV in its free (RSV-juice) or complexed (γ-CD·RSV-juice) form were stored along 28 days under dark and room temperature or at 4 °C. Initially, the RSV level in γ-CD·RSV-juice was about nine times higher than in RSV-juice (43.1% and 4.8%, respectively), suggesting that the RSV complexation promoted its solubility in the lemon juice, a fact that was still noticed after 28 days of storage. Moreover, regardless the fact that the antioxidant capacity was similar among the juices, the loss of antiradical ABTS•+ capacity in γ-CD·RSV-juice was reduced compared to that of the RSV-juice. Overall, this study allowed concluding that γ-CD can serve as a carrier of RSV, promoting its solubility and eventually protecting its antioxidant stability in lemon juices for at least 28 days.

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Section: Rsv Integrated In Juice Matrixcontrasting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Inclusion Complex of Resveratrol with γ-Cyclodextrin as a Functional Ingredient for Lemon Juices

Silva

Monteiro

Resende

et al. 2020

Foods

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“…Major characteristic peaks of RES were disappeared in case of RES-NS and a significant shift in O-H stretching was observed at 3300 cm −1 . Because of the structural similarity, OXY exhibited little change in characteristic vibrations at 3192 cm −1 (O–H stretching), 3038 cm −1 (C–H stretching of phenyl ring), 1611 cm −1 (C=C stretching), 1325 cm −1 (O–H bending) [17]. However, OXY-NS showed a significant shift in O–H stretching vibrations at 3200 cm −1 , a shift in the characteristic vibrations of RES-NS and OXY-NS might be due to the encapsulation of drug within the NSs [38].…”

Section: Resultsmentioning

confidence: 99%

“…Duarte et al, demonstrated the preparation of the inclusion complex of RES with methyl-β-cyclodextrin to improve its solubilization [16]. In another study, the effect of β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin on solubility and stability of OXY was studied [17]. However, nephrotoxicity of natural cyclodextrin, inability to accommodate macromolecules and limitation in providing a slow drug release profile requires an alternative delivery system [18].…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Solubility, Cytotoxicity and Photostability Studies of Resveratrol and Oxyresveratrol Loaded Nanosponges

et al. 2019

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Resveratrol and oxyresveratrol are natural polyphenolic stilbenes with several important pharmacological activities. However, low solubility and aqueous instability are the major limitations in their drug delivery applications. In the present work, we demonstrated the encapsulation of resveratrol and oxyresveratrol with nanosponge to improve solubility and stability. Several characterization techniques were used to confirm the encapsulation of both drug molecules within the nanosponges. The high encapsulation efficiency of resveratrol (77.73%) and oxyresveratrol (80.33%) was achieved within the nanosponges. Transmission electron microscopy suggested uniform spherical size particles of resveratrol and oxyresveratrol loaded nanosponges. Compared to free drugs, better protection against UV degradation was observed for resveratrol-loaded nanosponge (2-fold) and oxyresveratrol-loaded nanosponge (3-fold). Moreover, a higher solubilization of resveratrol- and oxyresveratrol-loaded nanosponges lead to a better antioxidant activity compared to drug molecules alone. Cytotoxicity studies against DU-145 prostate cancer cell lines further suggested improved activity of both resveratrol and oxyresveratrol-loaded nanosponges without any significant toxicity of blank nanosponges.

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“…Inclusion complexes of oxyresveratrol with β‐CD and HP‐β‐CD were prepared, and their autoxidation capacity was explored. The results indicated that β‐CD and HP‐β‐CD may enhance the stability of oxyresveratrol …”

Section: Application Of Inclusion Complexes In the Food Industrymentioning

confidence: 99%

The application and prospects of cyclodextrin inclusion complexes and polymers in the food industry: a review

Tian

Xiao

Hei

et al. 2020

Polymer International

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Cyclodextrin is an odorless and tasteless cyclic oligosaccharide widely used in various fields such as food, medicine and the environment. Cyclodextrin can improve solubility and stability, and can mask the bad taste of specific substances. Cyclodextrins and their polymers primarily act by forming complexes in foods, and can be applied in food packing, food analysis, enhancing the properties of antioxidants, antibacterials, for stability and so on. The challenges and opportunities facing this area are reviewed. It is hoped that the review will provide useful information for future applications of cyclodextrin in the food industry.

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Investigating the oxyresveratrol β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin complexes: The effects on oxyresveratrol solution, stability, and antibrowning ability on fresh grape juice

Cited by 28 publications

References 26 publications

Inclusion Complex of Resveratrol with γ-Cyclodextrin as a Functional Ingredient for Lemon Juices

Inclusion Complex of Resveratrol with γ-Cyclodextrin as a Functional Ingredient for Lemon Juices

Comparative Evaluation of Solubility, Cytotoxicity and Photostability Studies of Resveratrol and Oxyresveratrol Loaded Nanosponges

The application and prospects of cyclodextrin inclusion complexes and polymers in the food industry: a review

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