Comparative Evaluation of Solubility, Cytotoxicity and Photostability Studies of Resveratrol and Oxyresveratrol Loaded Nanosponges

Abstract

Resveratrol and oxyresveratrol are natural polyphenolic stilbenes with several important pharmacological activities. However, low solubility and aqueous instability are the major limitations in their drug delivery applications. In the present work, we demonstrated the encapsulation of resveratrol and oxyresveratrol with nanosponge to improve solubility and stability. Several characterization techniques were used to confirm the encapsulation of both drug molecules within the nanosponges. The high encapsulation efficiency of resveratrol (77.73%) and oxyresveratrol (80.33%) was achieved within the nanosponges. Transmission electron microscopy suggested uniform spherical size particles of resveratrol and oxyresveratrol loaded nanosponges. Compared to free drugs, better protection against UV degradation was observed for resveratrol-loaded nanosponge (2-fold) and oxyresveratrol-loaded nanosponge (3-fold). Moreover, a higher solubilization of resveratrol- and oxyresveratrol-loaded nanosponges lead to a better antioxidant activity compared to drug molecules alone. Cytotoxicity studies against DU-145 prostate cancer cell lines further suggested improved activity of both resveratrol and oxyresveratrol-loaded nanosponges without any significant toxicity of blank nanosponges.

Pure Trans-Resveratrol Nanoparticles Prepared by a Supercritical Antisolvent Process Using Alcohol and Dichloromethane Mixtures: Effect of Particle Size on Dissolution and Bioavailability in Rats

“…Further, its benefits are affected after its oral administration owing to its poor solubility and instability in physiological conditions as well as extensive metabolism [8,9]. To date, several formulation strategies such as amorphous solid dispersions, composite nanoparticles, emulsions, liposomes, polymeric micelles, self-emulsifying drug delivery systems, and solid lipid nanoparticles have been investigated to resolve this problem [10][11][12][13][14][15][16][17][18][19]. In addition, the enhanced oral bioavailability in humans has been reported with lipid formulation, micellar liquid formulation, and microparticles mixed with a liquid formulation [20][21][22].…”

Preparation and Evaluation of Resveratrol-Loaded Composite Nanoparticles Using a Supercritical Fluid Technology for Enhanced Oral and Skin Delivery

“…Due to these properties, trans -resveratrol is quickly metabolized, therefore skin application may be an alternative to oral administration [10,11,12]. Various formulation strategies, including the use of liposomes, solid dispersions, cyclodextrin complexes, solid lipid nanoparticles, emulsions, polymeric micelles, polymeric nanoparticles, and nanocrystals, have been evaluated to attempt to overcome current limitations of trans -resveratrol [13,14,15,16,17,18,19,20,21]. In particular, a pharmacokinetic study of twelve healthy volunteers given an oral administration of a capsule formulation of resveratrol via solubilization with micelles consisting of polysorbate 80, polysorbate 20, and medium chain triacylglycerol yielded increases in the area under the plasma concentration versus time curve ( AUC ) and maximum plasma concentration ( C max ) of resveratrol of 5.0-fold and 10.6-fold, respectively, compared to volunteers ingesting a resveratrol powder [19].…”

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

“…The nanoencapsulation (e.g. nanoemulsion, nanofibre, nanogel, nanoliposome, nanoparticle, nanotube, and nanosponge) coupled with phytochemicals provides promising avenues to explore possible strategies for enhancing efficacy and combating fungal resistance where conventional antifungal drugs prove to be ineffective ( Dhakar et al., 2019 ; Redondo-Blanco et al., 2019 ). Powers et al (2019) emphasized on the priority and importance of big data approaches for expediting the identification of active components.…”