Investigating the efficiency and tolerability of traditional Chinese formulas combined with antiarrhythmic agents for paroxysmal atrial fibrillation: A systematic review and Bayesian network meta-analysis

Jiang, Xiumin; Luo, Yongxin; Wang, Xiaotong; Chen, Yiming; Wang, Taiyi; He, Jia; Xia, Yucen; Zhao, Jiaying; Chai, Xiangping; Yao, Lin; Liu, Cun‐Zhi; Chen, Yongjun

doi:10.1016/j.phymed.2021.153832

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…According to the TCM pattern types, AF was classified into vigorous fire due to yin deficiency, qi deficiency and blood stasis, deficiency of both qi and yin, and phlegm-heat harassing the heart, and so on. The combination of TCM and antiarrhythmic drugs in the treatment of atrial fibrillation often achieves good results ( 4 ). Weiqin Guo ( 5 ) believes that the common pathomechanism basis of cardiac disorders is qi deficiency and blood stasis, so treatment emphasizes boosting qi and invigorating blood.…”

Section: Analysis Of the Entry Points Of The Advantages Of Chinese Me...mentioning

confidence: 99%

The application and mechanism of Chinese medicine in the upstream treatment of atrial fibrillation

Liu,

Mao,

Zhao

et al. 2023

Front. Cardiovasc. Med.

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Upstream treatment of atrial fibrillation (AF, for short) is a new approach to the prevention and treatment of AF with non-antiarrhythmic drugs, which is essentially primary and secondary prevention of AF. The former refers to the prevention of AF by controlling risk factors such as diabetes, hypertension, and heart failure before AF occurs, and the latter mainly refers to targeting ion channels, inflammation, oxidative stress, and other pathways to reduce or reverse atrial electrical and structural remodeling, reduction of AF load, and reduction of the chance of AF occurrence or progression. More and more studies have shown that many traditional Chinese medicines, active ingredients of Chinese medicines, and Chinese herbal formulas have definite effects on the upstream treatment of AF, but their mechanisms of action are different. Therefore, we summarized the relevant literature on the application and mechanisms of Chinese medicine on the upstream treatment of AF in recent years, hoping to be helpful for subsequent studies.

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Section: Analysis Of the Entry Points Of The Advantages Of Chinese Me...mentioning

confidence: 99%

The application and mechanism of Chinese medicine in the upstream treatment of atrial fibrillation

Liu,

Mao,

Zhao

et al. 2023

Front. Cardiovasc. Med.

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“…Previous multicenter clinical studies showed that SSYX capsule has a significant effect on the treatment of heart failure (HF) complicated by ventricular arrhythmia ( Liu et al, 2014 ; Wang X. et al, 2017 ; Cao et al, 2021 ). SSYX capsules have also been demonstrated to be effective in the treatment of paroxysmal AF ( Jiang et al, 2022 ). In cohorts without HF, studies have demonstrated the effectiveness of SSYX for the concomitant treatment of frequent premature ventricular contractions and sinus bradycardia (SB), and alleviation of the related symptoms ( Zou et al, 2011 ; Zhang F. et al, 2019 ).…”

Section: Translation In Modern Medicinementioning

confidence: 99%

Integrating Evidence of the Traditional Chinese Medicine Collateral Disease Theory in Prevention and Treatment of Cardiovascular Continuum

et al. 2022

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Cardiovascular disease has become a major public health problem. The concept of “cardiovascular continuum” refers to the continuous process from the risk factors that lead to arteriosclerosis, vulnerable plaque rupture, myocardial infarction, arrhythmia, heart failure, and death. These characteristics of etiology and progressive development coincide with the idea of “preventing disease” in traditional Chinese medicine (TCM), which corresponds to the process of systemic intervention. With the update of the understanding via translational medicine, this article reviews the current evidence of the TCM collateral disease theory set prescriptions in both mechanical and clinical aspects, which could lead to the development of new therapeutic strategies for prevention and treatment.

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“…Traditional Chinese medicine (TCM) has a unique cultural significance in China and has been widely used in the therapeutic research of AF, with classical Shensong Yangxin capsules (SSYX) being recognized for its efficacy. Based on the findings of previous drug and clinical studies, [4,5] we hypothesized that the use of SSYX combined with dronedarone after radiofrequency ablation of paroxysmal AF could further reduce the postoperative recurrence rate in patients postoperation. However, no relevant controlled trials have been conducted.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Shensong Yangxin capsule combined with dronedarone in paroxysmal atrial fibrillation after ablation

Zhou,

Gong,

et al. 2024

Medicine

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Objective: To investigate whether postoperative administration of Shensong Yangxin capsules (SSYX) and dronedarone for atrial fibrillation (AF) can reduce the recurrence of paroxysmal AF after radiofrequency ablation, thus providing a more optimal choice of antiarrhythmic medication during the blank period. Methods: We included 120 patients with paroxysmal AF who underwent radiofrequency ablation at our hospital between July 2020 and July 2022. They underwent routine circumferential pulmonary vein ablation and, subsequently, left and right atrial pressure monitoring to assess sinoatrial node recovery time under burst 400/300 ms stimulation. Postoperatively, the patients were randomly divided into 2 groups (60 patients each). The control group was administered dronedarone orally for 3 months and the study group was treated with SSYX combined with dronedarone. This study aimed to compare differences in clinical efficacy of the treatment between the 2 groups. Results: The left and right atrial pressures in both groups were higher than those in the preoperative period (P < .05), with no statistically significant differences between the 2 groups (P > .05). Sinoatrial node recovery time under burst 400/300 ms stimulation showed no statistical difference between the 2 groups (P > .05). At 3 months and 1 year postoperatively, the AFEQT scale scores for both groups were lower than those before treatment (P < .05), with the study group scoring lower than the control group at 3 months (P < .05). However, no statistically significant difference was observed between the 2 groups at 1 year postoperatively (P > .05). At 3 months postoperatively, the sinus rhythm maintenance rate and heart rate were higher in the intervention group than in the control group (P < .05); however, these differences between the 2 groups were not statistically significant at 1 year postoperatively (P > .05). Conclusion subsections: The combination of SSYX and dronedarone could effectively reduce the early recurrence of paroxysmal AF after radiofrequency ablation, increase heart rate, and improve the quality of life.

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Investigating the efficiency and tolerability of traditional Chinese formulas combined with antiarrhythmic agents for paroxysmal atrial fibrillation: A systematic review and Bayesian network meta-analysis

Cited by 8 publications

References 34 publications

The application and mechanism of Chinese medicine in the upstream treatment of atrial fibrillation

The application and mechanism of Chinese medicine in the upstream treatment of atrial fibrillation

Integrating Evidence of the Traditional Chinese Medicine Collateral Disease Theory in Prevention and Treatment of Cardiovascular Continuum

Efficacy of Shensong Yangxin capsule combined with dronedarone in paroxysmal atrial fibrillation after ablation

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