Integrating Evidence of the Traditional Chinese Medicine Collateral Disease Theory in Prevention and Treatment of Cardiovascular Continuum

Abstract

Cardiovascular disease has become a major public health problem. The concept of “cardiovascular continuum” refers to the continuous process from the risk factors that lead to arteriosclerosis, vulnerable plaque rupture, myocardial infarction, arrhythmia, heart failure, and death. These characteristics of etiology and progressive development coincide with the idea of “preventing disease” in traditional Chinese medicine (TCM), which corresponds to the process of systemic intervention. With the update of the understanding via translational medicine, this article reviews the current evidence of the TCM collateral disease theory set prescriptions in both mechanical and clinical aspects, which could lead to the development of new therapeutic strategies for prevention and treatment.

Bibliometric analysis of traditional Chinese medicine research on heart failure in the 21st century based on the WOS database

“…Community 3: The core member was HONGCAI SHANG, and other team members included JING CHEN, JIAYUAN HU, XINLI LI, etc. The studies mainly included Citri reticulatae pericarpium, postmyocardial infarction HF, peroxisome proliferator-activated receptor (PPAR) gamma, integrating evidence, and TCM collateral disease theory [ 29 , 30 , 31 ].…”

Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction

“…In this regard, developing novel treatments is a problem that needs to be addressed urgently. In recent years, the relationship between TCM and cardiovascular disease has received increased attention [ 27 – 29 ]. TCM compounds are known to comprise a diverse array of Chinese medicinal ingredients that act through various targets, channels, and pathways to address diseases.…”

A comprehensive quality evaluation strategy of Shensong Yangxin capsules based on qualitative, fingerprint and quantitative analyses

“…Shensong Yangxin capsules (SSYXC) are an effective Chinese patent medicine for the treatment of abnormal heart structure and function created by Chinese academician professor Wu Yiling and his academic team. In recent years, SSYXC has been widely used in the treatment of cardiovascular diseases, such as coronary heart disease, ventricular premature beating, paroxysmal atrial fibrillation and chronic heart failure (Cheang et al, 2022; Wang et al, 2011; Zeng et al, 2018; Zhao et al, 2016; Zou et al, 2011). It consists of 12 herbs: Panax ginseng C.A.Mey ., Ophiopogon japonicus (Linn.…”